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Protein Overview: OSM1

General Information:
Name(s) found: OSM1 / YJR051W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 501 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: metabolic process [TASLink to PubMed article]
    Molecular Function: fumarate reductase (NADH) activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRSVRRVFI YVSIFVLIIV LKRTLSGTDQ TSMKQPVVVI GSGLAGLTTS NRLISKYRIP  60
   61 VVLLDKAASI GGNSIKASSG INGAHTDTQQ NLKVMDTPEL FLKDTLHSAK GRGVPSLMDK 120
  121 LTKESKSAIR WLQTEFDLKL DLLAQLGGHS VPRTHRSSGK LPPGFEIVQA LSKKLKDISS 180
  181 KDSNLVQIML NSEVVDIELD NQGHVTGVVY MDENGNRKIM KSHHVVFCSG GFGYSKEMLK 240
  241 EYSPNLIHLP TTNGKQTTGD GQKILSKLGA ELIDMDQVQV HPTGFIDPND RENNWKFLAA 300
  301 EALRGLGGIL LHPTTGRRFT NELSTRDTVT MEIQSKCPKN DNRALLVMSD KVYENYTNNI 360
  361 NFYMSKNLIK KVSINDLIRQ YDLQTTASEL VTELKSYSDV NTKDTFDRPL IINAFDKDIS 420
  421 TESTVYVGEV TPVVHFTMGG VKINEKSQVI KKNSESVLSN GIFAAGEVSG GVHGANRLGG 480
  481 SSLLECVVFG KTAADNIAKL Y

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CSL4 DDI1 DIS3 ENT3 LRP1 MPP6 MTR3 OSM1 RRP4 RRP40 RRP42 RRP43 RRP45 RRP46 RRP6 SKI6 SKI7 YBL055C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HRT1 OSM1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OSM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..280]
    [434..501]    		 PSI-BLAST 642.0 Flavocytochrome c3 (respiratory fumarate reductase), N-terminal domain; Flavocytochrome c3 (respiratory fumarate reductase)
    2 View Details [281..433] PSI-BLAST 642.0 Flavocytochrome c3 (respiratory fumarate reductase), N-terminal domain; Flavocytochrome c3 (respiratory fumarate reductase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • succinate dehydrogenase activity
    		•  4.66525249592263 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
    		•  3.70791057697947 bayes_pls_golite062009
  • succinate dehydrogenase (ubiquinone) activity
    		•  3.70791057697947 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.25470541847124 bayes_pls_golite062009
  • electron carrier activity
    		•  2.8553929424231 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  2.84060092432585 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  2.78793325009909 bayes_pls_golite062009
  • L-aspartate oxidase activity
    		•  2.52327499022066 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  2.26549080531565 bayes_pls_golite062009
  • aspartate oxidase activity
    		•  2.16464783424214 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.11247286526577 bayes_pls_golite062009
  • catalytic activity
    		•  1.75556359035561 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  1.73872135285388 bayes_pls_golite062009
  • binding
    		•  1.41440014472974 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
    		•  0.932244769173724 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  0.798505263716232 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  0.71497408952162 bayes_pls_golite062009
  • fumarate reductase (NADH) activity
    		•  0.65260793370113 bayes_pls_golite062009
  • succinate-CoA ligase activity
    		•  0.468246082354334 bayes_pls_golite062009
  • coenzyme binding
    		•  0.44036421821989 bayes_pls_golite062009
  • protein binding
    		•  0.159209309982354 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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