YRC Public Data Repository - Protein Structure Prediction

Protein:	OSM1
Organism:	Saccharomyces cerevisiae
Length:	501 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OSM1.

Description	E-value	Query Range	Subject Range
OSM1_YEAST - Fumarate reductase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OSM1 PE=1 SV=3 OSM1 - Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation o... gi\|151945119 - gi\|151945119\|gb\|EDN63370.1\| osmotic growth protein [Saccharomyces cerevisiae YJM789] gi\|190409528 - gi\|190409528\|gb\|EDV12793.1\| osmotic growth protein [Saccharomyces cerevisiae RM11-1a]	0.0	[1..501]	[1..501]
SDHA_SCHPO - Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Schizosaccharom... sdh1 - succinate dehydrogenase Sdh1	0.0	[18..497]	[38..465]
gi\|11252510 - pir\|\|E82728 succinate dehydrogenase, flavoprotein subunit XF1072 [imported] - Xylella fastidiosa (st... gi\|15837674, gi\|... - gi\|9106019\|gb\|AAF83882.1\|AE003943_13 succinate dehydrogenase, flavoprotein subunit [Xylella fastidio...	0.0	[25..500]	[1..425]
gi\|15030102 - gi\|15030102\|gb\|AAH11301.1\| Sdha protein [Mus musculus]	0.0	[18..499]	[42..470]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[37..498]	[6..466]
SDHA_RAT - Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Rattus norvegicus GN=Sdh...	0.0	[18..499]	[37..465]
gi\|1510133 - gi\|1510133\|dbj\|BAA13119.1\| flavoprotein subunit of succinate dehydrogenase [Plasmodium falciparum]	0.0	[18..500]	[6..445]
gi\|25284622, gi\|... - pir\|\|AB2901 succinate dehydrogenase flavoprotein subunit sdhA [imported] - Agrobacterium tumefaciens... gi\|15889899, gi\|... - gi\|17936518\|ref\|NP_533308.1\| succinate dehydrogenase [Agrobacterium tumefaciens str. C58], gi\|177411...	0.0	[27..500]	[13..435]

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Predicted Domain #1

Region A:
Residues: [1-280]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRSVRRVFI YVSIFVLIIV LKRTLSGTDQ TSMKQPVVVI GSGLAGLTTS NRLISKYRIP  60
   61 VVLLDKAASI GGNSIKASSG INGAHTDTQQ NLKVMDTPEL FLKDTLHSAK GRGVPSLMDK 120
  121 LTKESKSAIR WLQTEFDLKL DLLAQLGGHS VPRTHRSSGK LPPGFEIVQA LSKKLKDISS 180
  181 KDSNLVQIML NSEVVDIELD NQGHVTGVVY MDENGNRKIM KSHHVVFCSG GFGYSKEMLK 240
  241 EYSPNLIHLP TTNGKQTTGD GQKILSKLGA ELIDMDQVQV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [434-501]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHFTMGGVKI NEKSQVIKKN SESVLSNGIF AAGEVSGGVH GANRLGGSSL LECVVFGKTA  60
   61 ADNIAKLY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	642.0
Match:	1qo8A_
Description:	Flavocytochrome c3 (respiratory fumarate reductase), N-terminal domain; Flavocytochrome c3 (respiratory fumarate reductase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
succinate dehydrogenase activity	4.66525249592263	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	3.70791057697947	bayes_pls_golite062009
succinate dehydrogenase (ubiquinone) activity	3.70791057697947	bayes_pls_golite062009
oxidoreductase activity	3.25470541847124	bayes_pls_golite062009
electron carrier activity	2.8553929424231	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	2.84060092432585	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	2.78793325009909	bayes_pls_golite062009
L-aspartate oxidase activity	2.52327499022066	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	2.26549080531565	bayes_pls_golite062009
aspartate oxidase activity	2.16464783424214	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.11247286526577	bayes_pls_golite062009
catalytic activity	1.75556359035561	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	1.73872135285388	bayes_pls_golite062009
binding	1.41440014472974	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	0.932244769173724	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors	0.798505263716232	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	0.71497408952162	bayes_pls_golite062009
fumarate reductase (NADH) activity	0.65260793370113	bayes_pls_golite062009
succinate-CoA ligase activity	0.468246082354334	bayes_pls_golite062009
coenzyme binding	0.44036421821989	bayes_pls_golite062009
protein binding	0.159209309982354	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [281-433]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPTGFIDPND RENNWKFLAA EALRGLGGIL LHPTTGRRFT NELSTRDTVT MEIQSKCPKN  60
   61 DNRALLVMSD KVYENYTNNI NFYMSKNLIK KVSINDLIRQ YDLQTTASEL VTELKSYSDV 120
  121 NTKDTFDRPL IINAFDKDIS TESTVYVGEV TPV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	642.0
Match:	1qo8A_
Description:	Flavocytochrome c3 (respiratory fumarate reductase), N-terminal domain; Flavocytochrome c3 (respiratory fumarate reductase)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: