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Protein Overview: ENT5

General Information:
Name(s) found: ENT5 / YDR153C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 411 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    clathrin vesicle coat [IDALink to PubMed article]
    Biological Process: protein targeting [IMPLink to PubMed article]
    Golgi to endosome transport [IMPLink to PubMed article]
    Molecular Function: clathrin binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSLSKKIQN LGIHDIRNAA RFAQNVIVQY EPYQIDIRRA TNTDAWGPTP KHLAKVLRNR  60
   61 YQVPLYLMTE YTLKRLVDHI ATRPKNLYEK ARKDYVNYGS EWRVVLKCLV VIEFLLLNVD 120
  121 TGDELNQIRS CLLTHKHILT REIAQFKVKF SNDGKMEIHE RGIRKKGELI LQYLEDSQFL 180
  181 KKERAKNKKN ALKIRQQGES SIYNANQIST SASYDNIDDD EFDADADGFD SEMDANNVTN 240
  241 FNVPVETEAN SNTRRRSHME EQRRQRREIL REQIKNKEQQ RKRKQQQDSI PDLIDLDDST 300
  301 STTNNITIDN GNNDNKNNNI NSNSDDDDDE FGDFQSETSP DTTAPKTSNS KIDDLLDWDG 360
  361 PKSDTDTTAA AQTSLPFAEK KQQKARPQAT KDKSKGNDAF SDLFSYSKSL V

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ENT5 SKI2 SKI3 SKI8 YKL023W
    View Details Qiu et al. (2008) APL2 APL4 APL5 APM1 APM2 APS1 ENT3 ENT5 VPS51

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ENT5 and CHC1 Huh WK, et al. (2003)
    View Data ENT5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..219] PSI-BLAST 83.68867 Epsin 1
    2 View Details [220..411] PSI-BLAST 3.0 Fibrinogen

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • clathrin binding
    		•  7.05477548709703 bayes_pls_golite062009
  • protein binding
    		•  2.16467447169895 bayes_pls_golite062009
  • binding
    		•  2.0426788146333 bayes_pls_golite062009
  • phospholipid binding
    		•  1.38798066582556 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.26458267960741 bayes_pls_golite062009
  • lipid binding
    		•  0.176990783274449 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle