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Protein Overview: SKI8

General Information:
Name(s) found: SKI8 / YGL213C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 397 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IPILink to PubMed article]
    nuclear chromosome [IDALink to PubMed article]
    Biological Process: protein complex assembly [IMPLink to PubMed article]
    response to exogenous dsRNA [IMPLink to PubMed article]
    mRNA catabolic process [IMPLink to PubMed article][TASLink to PubMed article]
    meiotic DNA double-strand break formation [IPILink to PubMed article]
    Molecular Function: translation repressor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKVFIATAN AGKAHDADIF SVSACNSFTV SCSGDGYLKV WDNKLLDNEN PKDKSYSHFV  60
   61 HKSGLHHVDV LQAIERDAFE LCLVATTSFS GDLLFYRITR EDETKKVIFE KLDLLDSDMK 120
  121 KHSFWALKWG ASNDRLLSHR LVATDVKGTT YIWKFHPFAD ESNSLTLNWS PTLELQGTVE 180
  181 SPMTPSQFAT SVDISERGLI ATGFNNGTVQ ISELSTLRPL YNFESQHSMI NNSNSIRSVK 240
  241 FSPQGSLLAI AHDSNSFGCI TLYETEFGER IGSLSVPTHS SQASLGEFAH SSWVMSLSFN 300
  301 DSGETLCSAG WDGKLRFWDV KTKERITTLN MHCDDIEIEE DILAVDEHGD SLAEPGVFDV 360
  361 KFLKKGWRSG MGADLNESLC CVCLDRSIRW FREAGGK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SKI2 SKI3 SKI8 YKL023W
    View Details Krogan NJ, et al. (2006) ENT5 SKI2 SKI3 SKI8 YKL023W
    View Details Gavin AC, et al. (2006) SKI2 SKI3 SKI8
    View Details Ho Y, et al. (2002) AKL1 SKI2 SKI3 SKI8
    View Details Qiu et al. (2008) SKI2 SKI8

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPO11 SKI8 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SKI8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..397] PSI-BLAST 61.0 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 3.12192428374026 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • RNA binding
    		•  2.1927334052131 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.95667720244696 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.90457914882449 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.7032681012791 bayes_pls_golite062009
  • structural molecule activity
    		•  1.47448876401574 bayes_pls_golite062009
  • DNA binding
    		•  1.38475369554616 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • transcription factor activity
    		•  0.804334981068351 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.722742354759599 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.625780732991652 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.560226369775279 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.48827205019881 bayes_pls_golite062009
  • transcription factor binding
    		•  0.412844855996155 bayes_pls_golite062009
  • snoRNA binding
    		•  0.347797037104681 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.2578464839973 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.19391619547146 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.0403785360444822 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.00954741955203087 bayes_pls_golite062009
  • actin binding
    		•  0.00606924241186668 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle