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Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin. Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle. Catalysis of the reaction: Catalysis of the reaction: ATP + ubiquitin + protein N-ubiquityl(n)lysine = AMP + diphosphate + protein N-ubiquityl(n+1)lysine, i.e. the ligation of ubiquitin moieties, via isopeptide bonds, to extend the length of the multiubiquitin chain attached to a substrate protein.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ubiquitin-protein ligase activity
Acc: GO:0004842
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Synonyms:
  • ubiquitin ligase activity
  • ubiquitin conjugating enzyme activity
  • anaphase-promoting complex activity
  • ubiquitin protein-ligase activity
  • E2
  • E3
  • GO:0004841
  • GO:0004840
  • ubiquitin activity
  • ubiquitin-conjugating enzyme activity
  • ubiquitin-ligase activity
  • ubiquitin protein ligase activity
  • ubiquitin:protein-lysine N-ligase (AMP-forming) activity
Proteins in PDR annotated with:
   This term: 812 [Search]
   Term or descendants: 820 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004842 - ubiquitin-protein ligase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle