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Protein Overview: APS1

General Information:
Name(s) found: APS1 / YLR170C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 156 amino acids

    Gene Ontology:
    Cellular Component: AP-1 adaptor complex [IPILink to PubMed article][ISSLink to PubMed article]
    Biological Process: vesicle-mediated transport [IPILink to PubMed article][ISSLink to PubMed article]
    Golgi to vacuole transport [IMPLink to PubMed article]
    Molecular Function: clathrin binding [IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQLKYLLLV SRQGKIRLKK WYTAMSAGEK AKIVKDLTPT ILARKPKMCN IIEYNDHKVV  60
   61 YKRYASLYFI VGMTPDVDNE LLTLEIIHRF VETMDTYFGN VCELDIIFNF SKVYDILNEM 120
  121 IMCDGSIAES SRKEVLHHVT VMDTMESNDN LERVLS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) APL2 APL4 APM1 APM2 APS1
    View Details (MIPS) Mewes HW, et al. (2004) APL2 APL4 APM1 APS1
    View Details Krogan NJ, et al. (2006) APL2 APL4 APM1 APM2 APS1 CST26 GAL10 IRC6 YFL034W
    View Details Gavin AC, et al. (2006) APL2 APL4 APM1 APM2 APS1
    View Details Gavin AC, et al. (2002) APL2 APL4 APM1 APM2 APS1 MIS1 RPA135
    View Details Qiu et al. (2008) APL2 APL4 APL5 APM1 APM2 APS1 ENT5 YOS1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] PSI-BLAST 297.165202 Sigma2 adaptin (clathrin coat assembly protein AP17)
    2 View Details [89..156] PSI-BLAST 297.165202 Sigma2 adaptin (clathrin coat assembly protein AP17)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle