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Protein Overview: CHC1

General Information:
Name(s) found: CHC1 / YGL206C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1653 amino acids

    Gene Ontology:
    Cellular Component: clathrin vesicle coat [TASLink to PubMed article]
    Biological Process: vesicle-mediated transport [TASLink to PubMed article]
    endocytosis [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: structural molecule activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLPIEFTE LVDLMSLGIS PQFLDFRSTT FESDHFVTVR ETKDGTNSVA IVDLAKGNEV  60
   61 TRKNMGGDSA IMHPSQMVIS VRANGTIVQI FNLETKSKLK SFTLDEPVIF WRWLSETTLG 120
  121 FVTARSILTS NVFDGNVNAK PQLLTLRHAN LNNTQIINFV ANKNLDWFAV VGILQENGRI 180
  181 AGRIQLFSKQ RNISQAIDGH VAIFTNILLE GNGSTPVQVF VTGNRNATTG AGELRIIEID 240
  241 HDASLPSQYQ KETTDIFFPP DATNDFPIAV QVSEKYGIIY LLTKYGFIHL YELETGTNLF 300
  301 VNRITAESVF TAAPYNHENG IACINKKGQV LAVEISTSQI VPYILNKLSN VALALIVATR 360
  361 GGLPGADDLF QKQFESLLLQ NDYQNAAKVA ASSTSLRNQN TINRLKNIQA PPGAISPILL 420
  421 YFSTLLDKGK LNKEETIELA RPVLQQDRKQ LFEKWLKEDK LECSEELGDI VKPFDTTLAL 480
  481 ACYLRAGAHA KVISCLAELQ QFEKIIPYCQ KVGYQPNFLV LISSLIRSSP DRASEFAVSL 540
  541 LQNPETASQI DIEKIADLFF SQNHIQQGTS LLLDALKGDT PDQGHLQTRV LEVNLLHAPQ 600
  601 VADAILGNNI FSHYDKPTIA SLSEKAGLYQ RALENYTDIK DIKRCVVHTN ALPIDWLVGY 660
  661 FGKLNVEQSL ACLKALMDNN IQANIQTVVQ VATKFSDLIG PSTLIKLFED YNATEGLYYY 720
  721 LASLVNLTED KDVVYKYIEA AAKMKQYREI ERIVKDNNVY DPERVKNFLK DANLEDQLPL 780
  781 VIVCDRFDFV HEMILYLYKS QNLKFIETYV QQVNPSKTAQ VVGALLDMDC DEAFIQSLLQ 840
  841 SVLGQVPINE LTTEVEKRNR LKILLPFLEQ SLSQGIQDQA VYNALAKIYI DSNNSPEKFL 900
  901 KENDQYDTLD VGHYCEKRDP YLAYIAYEKG QNDDDLIRIT NENSMYKYQA RYLLERSDLD 960
  961 LWNKVLNQEN IHRRQLIDSV ISVGIPELTD PEPVSLTVQA FMTNGLKLEL IELLEKIILE1020
 1021 PSPFNENVAL QGLLLLSAIK YEPTKVSSYI EKLDNYDADE IAPLCIEHDL KEEAFEIYDK1080
 1081 HEMYGKALKV LIEDIMSLDR AASYADKINT PELWSQIGTA QLDGLRIPDA IESYIKAEDP1140
 1141 SNYENVIDIA EQAGKYEELI PFLLMARKTL KEPKIDGALI LAYAELNKIH EIENLLAGSN1200
 1201 VANLDHVGDK LFENKEYKAA RLCYSAVSNY SKLASTLVYL GDYQAAVDTA RKASNIKVWK1260
 1261 LVNDACIEKK EFKLAQICGL NLIVHAEELD ELVERYESNG YFEELISLFE AGLGLERAHM1320
 1321 GMFTELAILY SKYEPDKTFE HLKLFWSRIN IPKVIRAVEQ AHLWSELVFL YAHYDEWDNA1380
 1381 ALTLIEKSTK DLDHAYFKEV VVKVSNLEIY YKAINFYVKF HPSLLVDLLT SLTPRLDIPR1440
 1441 TVKIFSKSDN LPLIKPFLIN VLPKNNSVVN QAYHDLMIEE EDYKALQDAV DSYDKFDQLG1500
 1501 LASRLESHKL IFFKKIGALL YRRNKKWAKS LSILKEEKLW KDAIETAAIS QDPKVVEALL1560
 1561 TYFVETGNRE GFVALLYAAY NLVRIEFVLE ISWMNSLEDY IKPFEISIKK EQNDSIKKIT1620
 1621 EELAKKSGSN EEHKDGQPLM LMNSAMNVQP TGF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CHC1 CLC1
    View Details (MIPS) Mewes HW, et al. (2004) CHC1 CLC1
    View Details Krogan NJ, et al. (2006) CHC1 CLC1
    View Details Gavin AC, et al. (2006) CHC1 CLC1
    View Details Gavin AC, et al. (2002) ASC1 BSP1 BZZ1 CCT4 CHC1 CLC1 COG8 ECM25 END3 GCD1 GCD11 GCD2 GCD6 GCD7 GCN1 GCN3 GGA2 GUT1 INP52 IST1 LAS17 LSB3 LYS12 PDC1 PRO1 RAD51 RRP40 RRP46 SLA1 SLA2 STM1 SUI2 SUI3 SYP1 TFP1 TSA1 VRP1 XKS1 YHB1 YPT7 YSC84
    View Details Qiu et al. (2008) CHC1 CLC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run KOG1 No Comments Reinke A, et al. (2004)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run ASF1 sample 3121 run on DecaLCQ: searched for phosphorylation Green EM, et al (2005)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample zds1 from august 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample zds1 gel band from august 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run BOI2 Boi 2 gst control McCusker D, et al (2007)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LDB19 and CHC1 Huh WK, et al. (2003)
    View Data SCY1 and CHC1 Huh WK, et al. (2003)
    View Data VPS45 and CHC1 Huh WK, et al. (2003)
    View Data YPR089W and CHC1 Huh WK, et al. (2003)
    View Data CHC1 and CHC1 Huh WK, et al. (2003)
    View Data MON1 and CHC1 Huh WK, et al. (2003)
    View Data APM1 and CHC1 Huh WK, et al. (2003)
    View Data ENT5 and CHC1 Huh WK, et al. (2003)
    View Data GGA1 and CHC1 Huh WK, et al. (2003)
    View Data TRS20 and CHC1 Huh WK, et al. (2003)
    View Data YHL017W and CHC1 Huh WK, et al. (2003)
    View Data FLC2 and CHC1 Huh WK, et al. (2003)
    View Data TRS130 and CHC1 Huh WK, et al. (2003)
    View Data TCA17 and CHC1 Huh WK, et al. (2003)
    View Data ARF1 and CHC1 Huh WK, et al. (2003)
    View Data CPD1 and CHC1 Huh WK, et al. (2003)
    View Data ARF2 and CHC1 Huh WK, et al. (2003)
    View Data TRS23 and CHC1 Huh WK, et al. (2003)
    View Data BET3 and CHC1 Huh WK, et al. (2003)
    View Data BSC6 and CHC1 Huh WK, et al. (2003)
    View Data YBL010C and CHC1 Huh WK, et al. (2003)
    View Data TRS120 and CHC1 Huh WK, et al. (2003)
    View Data CHS5 and CHC1 Huh WK, et al. (2003)
    View Data CLC1 and CHC1 Huh WK, et al. (2003)
    View Data TRS31 and CHC1 Huh WK, et al. (2003)
    View Data SMI1 and CHC1 Huh WK, et al. (2003)
    View Data CHS3 and CHC1 Huh WK, et al. (2003)
    View Data STV1 and CHC1 Huh WK, et al. (2003)
    View Data CDC50 and CHC1 Huh WK, et al. (2003)
    View Data YML037C and CHC1 Huh WK, et al. (2003)
    View Data TVP18 and CHC1 Huh WK, et al. (2003)
    View Data SEC7 and CHC1 Huh WK, et al. (2003)
    View Data BCH2 and CHC1 Huh WK, et al. (2003)
    View Data LAA1 and CHC1 Huh WK, et al. (2003)
    View Data BUD7 and CHC1 Huh WK, et al. (2003)
    View Data AGE2 and CHC1 Huh WK, et al. (2003)
    View Data CHS6 and CHC1 Huh WK, et al. (2003)
    View Data DNF1 and CHC1 Huh WK, et al. (2003)
    View Data APL2 and CHC1 Huh WK, et al. (2003)
    View Data BCH1 and CHC1 Huh WK, et al. (2003)
    View Data GYP6 and CHC1 Huh WK, et al. (2003)
    View Data TVP38 and CHC1 Huh WK, et al. (2003)
    View Data DRS2 and CHC1 Huh WK, et al. (2003)
    View Data TVP23 and CHC1 Huh WK, et al. (2003)
    View Data APM2 and CHC1 Huh WK, et al. (2003)
    View Data GGA2 and CHC1 Huh WK, et al. (2003)
    View Data CHC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..12]
    [199..362]    		 PSI-BLAST 2230.0 Clathrin heavy-chain linker domain; Clathrin heavy-chain terminal domain
    2 View Details [13..144]
    [363..430]    		 PSI-BLAST 2230.0 Clathrin heavy-chain linker domain; Clathrin heavy-chain terminal domain
    3 View Details [145..198]
    [431..498]    		 PSI-BLAST 2230.0 Clathrin heavy-chain linker domain; Clathrin heavy-chain terminal domain
    4 View Details [499..561] ORFEUS 12.01 Annexin VI
    5 View Details [562..806] ORFEUS 12.01 Annexin VI
    6 View Details [807..822]
    [894..1077]    		 ORFEUS 12.01 Annexin VI
    7 View Details [823..893] ORFEUS 12.01 Annexin VI
    8 View Details [1078..1550] PSI-BLAST 2330.0 Clathrin heavy chain proximal leg segment
    9 View Details [1551..1653] MSA 2.012966 View MSA. Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle