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Protein Overview: KOG1

General Information:
Name(s) found: KOG1 / YHR186C [SGD]
Description(s) found:
Found 19 descriptions.
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  • Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1557 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed articleLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    TORC1 complex [IPILink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: regulation of cell growth [IPILink to PubMed article]
    cellular response to starvation [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEIYGPQPL KPLNTVMRHG FEEQYQSDQL LQSLANDFIF YFDDKRHKTN GNPIPEEDKQ  60
   61 RDVNRYYQPI TDWKIMKDRQ KTVSAALLLC LNLGVDPPDV MKTHPCARVE AWVDPLNFQD 120
  121 SKKAIEQIGK NLQAQYETLS LRTRYKQSLD PCVEDVKRFC NSLRRTSKED RILFHYNGHG 180
  181 VPKPTKSGEI WVFNRGYTQY IPVSLYDLQT WLGAPCIFVY DCNSAENILI NFQKFVQKRI 240
  241 KDDEEGNHDV AAPSPTSAYQ DCFQLASCTS DELLLMSPEL PADLFSCCLT CPIEISIRIF 300
  301 LMQSPLKDSK YKIFFENSTS NQPFGDSKNS FKSKIPNVNI PGMLSDRRTP LGELNWIFTA 360
  361 ITDTIAWTSL PRPLFKKLFR HDLMIAALFR NFLLAKRIMP WYNCHPVSDP ELPDSITTHP 420
  421 MWKSWDLAMD EVLTKIVIDL KNAPPATALE SQMILQQQET LQNGGSSKSN AQDTKAGSIQ 480
  481 TQSRFAVANL STMSLVNNPA LQSRKSISLQ SSQQQLQQQQ QQQQQFTGFF EQNLTAFELW 540
  541 LKYASNVRHP PEQLPIVLQV LLSQVHRIRA LVLLSRFLDL GPWAVYLSLS IGIFPYVLKL 600
  601 LQSPAPELKP ILVFIWARIM SIDYKNTQSE LIKEKGYMYF VTVLVPDWGV NGMSATNGSA 660
  661 MINSGNPLTM TASQNINGPS SRYYERQQGN RTSNLGHNNL PFYHSNDTTD EQKAMAVFVL 720
  721 ASFVRNFPLG QKNCFSLELV NKLCFYIDNS EIPLLRQWCV ILLGLLFADN PLNRFVCMNT 780
  781 GAVEILLKSL KDPVPEVRTA SIFALKHFIS GFQDAEVILR LQQEFEEQYQ QLHSQLQHLQ 840
  841 NQSHLQQQQS QQQQQHLEQQ QMKIEKQIRH CQVMQNQLEV IDLRKLKRQE IGNLISILPL 900
  901 INDGSSLVRK ELVVYFSHIV SRYSNFFIVV VFNDLLEEIK LLEKSDINTR NTSDKYSVSQ 960
  961 GSIFYTVWKS LLILAEDPFL ENKELSKQVI DYILLELSAH KELGGPFAVM EKFLLKRSSK1020
 1021 AHQTGKFGFN SSQVQFVKSS LRSFSPNERV DNNAFKKEQQ QHDPKISHPM RTSLAKLFQS1080
 1081 LGFSESNSDS DTQSSNTSMK SHTSKKGPSG LYLLNGNNNI YPTAETPRFR KHTEPLQLPL1140
 1141 NSSFLDYSRE YFQEPQMKKQ EADEPGSVEY NARLWRRNRN ETIIQETQGE KKLSIYGNWS1200
 1201 KKLISLNNKS QPKLMKFAQF EDQLITADDR STITVFDWEK GKTLSKFSNG TPFGTKVTDL1260
 1261 KLINEDDSAL LLTGSSDGVI KIYRDYQDVD TFKIVSAWRG LTDMLLTPRS TGLLTEWLQI1320
 1321 RGSLLTTGDV KVIRVWDAHT ETVEVDIPAK TSSLITSLTA DQLAGNIFVA GFADGSLRVY1380
 1381 DRRLDPRDSM IRRWRAGNDK QGVWINNVHL QRGGYRELVS GATNGVVELW DIRSEDPVES1440
 1441 FVDQNVTSQY GSQQKPTTMT CMQVHEHAPI IATGTKQIKI WTTSGDLLNS FKNSHNNGVT1500
 1501 STLAATGIPK SLSYSSTSDA FLSSMAFHPH RMMIAATNSH DSIVNIYKCE DERIDYF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ARO1 BCK1 CHS1 CMP2 DBP7 GLC7 HXT6 KOG1 KSP1 NET1 NOP6 NSR1 PMA1 PMA2 PPZ2 PRI2 PSY2 REG1 RSE1 RVB1 SDS22 SNF4 TPD3 VPH2 YGR130C
    View Details Qiu et al. (2008) KOG1 TCO89 TOR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run KOG1 No Comments Reinke A, et al. (2004)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data KOG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..792] Pcons 1.52 Karyopherin alpha
    2 View Details [793..1017] MSA 3.082997 View MSA. No confident structure predictions are available.
    3 View Details [1018..1384] PSI-BLAST 17.69897 Arp2/3 complex 41 kDa subunit ARPC1
    4 View Details [1385..1557] PSI-BLAST 75.522879 beta1-subunit of the signal-transducing G protein heterotrimer
    5 View Details [414..948] FFAS03 1.26 Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP
    6 View Details [949..1029] FFAS03 1.42 Mouse Importin alpha- phosphorylated SV40 CN peptide complex
    7 View Details [1030..1136] PSI-BLAST 19.69897 Arp2/3 complex 41 kDa subunit ARPC1
    8 View Details [1137..1557] PSI-BLAST 76.0 No description for 2ovpB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.53151481871847 bayes_pls_golite062009
  • protein binding
    		•  1.61131270705552 bayes_pls_golite062009
  • signal transducer activity
    		•  1.07458868889742 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.07458868889742 bayes_pls_golite062009
  • hydrolase activity
    		•  0.481485720915241 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.374110439235743 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.72

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle