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Protein: KOG1
Organism: Saccharomyces cerevisiae
Length: 1557 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KOG1.

Description E-value Query
Range		 Subject
Range
KOG1 - Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or To...
gi|151944130 - gi|151944130|gb|EDN62423.1| TORC1 subunit [Saccharomyces cerevisiae YJM789]
KOG1_YEAST - Target of rapamycin complex 1 subunit KOG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
 0.0 [1..1557] [1..1557]
gi|11358141, gi|... - gi|7329650|emb|CAB82747.1| putative protein [Arabidopsis thaliana], gi|15241060|ref|NP_195797.1| RAP...
 0.0 [71..1430] [86..1345]
mip1 - WD repeat protein Mip1
MIP1_SCHPO - Target of rapamycin complex 1 subunit mip1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...
 0.0 [18..1376] [61..1291]
raptor-PA - The gene raptor is referred to in FlyBase by the symbol Dmel\raptor (CG4320, FBgn0029840). It is a p...
 0.0 [45..809] [178..895]
gi|7242961 - gi|7242961|dbj|BAA92541.1| KIAA1303 protein [Homo sapiens]
 0.0 [247..1525] [9..1114]
gi|12855312 - gi|12855312|dbj|BAB30288.1| unnamed protein product [Mus musculus]
 0.0 [212..996] [1..655]
daf-15 - status:Confirmed UniProt:Q9XTJ1 protein_id:CAA93507.2
 0.0 [74..594] [62..578]

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Predicted Domain #1
Region A:
Residues: [1-792] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEIYGPQPL KPLNTVMRHG FEEQYQSDQL LQSLANDFIF YFDDKRHKTN GNPIPEEDKQ  60
   61 RDVNRYYQPI TDWKIMKDRQ KTVSAALLLC LNLGVDPPDV MKTHPCARVE AWVDPLNFQD 120
  121 SKKAIEQIGK NLQAQYETLS LRTRYKQSLD PCVEDVKRFC NSLRRTSKED RILFHYNGHG 180
  181 VPKPTKSGEI WVFNRGYTQY IPVSLYDLQT WLGAPCIFVY DCNSAENILI NFQKFVQKRI 240
  241 KDDEEGNHDV AAPSPTSAYQ DCFQLASCTS DELLLMSPEL PADLFSCCLT CPIEISIRIF 300
  301 LMQSPLKDSK YKIFFENSTS NQPFGDSKNS FKSKIPNVNI PGMLSDRRTP LGELNWIFTA 360
  361 ITDTIAWTSL PRPLFKKLFR HDLMIAALFR NFLLAKRIMP WYNCHPVSDP ELPDSITTHP 420
  421 MWKSWDLAMD EVLTKIVIDL KNAPPATALE SQMILQQQET LQNGGSSKSN AQDTKAGSIQ 480
  481 TQSRFAVANL STMSLVNNPA LQSRKSISLQ SSQQQLQQQQ QQQQQFTGFF EQNLTAFELW 540
  541 LKYASNVRHP PEQLPIVLQV LLSQVHRIRA LVLLSRFLDL GPWAVYLSLS IGIFPYVLKL 600
  601 LQSPAPELKP ILVFIWARIM SIDYKNTQSE LIKEKGYMYF VTVLVPDWGV NGMSATNGSA 660
  661 MINSGNPLTM TASQNINGPS SRYYERQQGN RTSNLGHNNL PFYHSNDTTD EQKAMAVFVL 720
  721 ASFVRNFPLG QKNCFSLELV NKLCFYIDNS EIPLLRQWCV ILLGLLFADN PLNRFVCMNT 780
  781 GAVEILLKSL KD

[Run NCBI BLAST on this sequence.]

Detection Method: Pcons
Confidence: 1.52
Match: 1bk6A
Description: Karyopherin alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [793-1017] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVPEVRTASI FALKHFISGF QDAEVILRLQ QEFEEQYQQL HSQLQHLQNQ SHLQQQQSQQ  60
   61 QQQHLEQQQM KIEKQIRHCQ VMQNQLEVID LRKLKRQEIG NLISILPLIN DGSSLVRKEL 120
  121 VVYFSHIVSR YSNFFIVVVF NDLLEEIKLL EKSDINTRNT SDKYSVSQGS IFYTVWKSLL 180
  181 ILAEDPFLEN KELSKQVIDY ILLELSAHKE LGGPFAVMEK FLLKR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [1018-1384] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSKAHQTGKF GFNSSQVQFV KSSLRSFSPN ERVDNNAFKK EQQQHDPKIS HPMRTSLAKL  60
   61 FQSLGFSESN SDSDTQSSNT SMKSHTSKKG PSGLYLLNGN NNIYPTAETP RFRKHTEPLQ 120
  121 LPLNSSFLDY SREYFQEPQM KKQEADEPGS VEYNARLWRR NRNETIIQET QGEKKLSIYG 180
  181 NWSKKLISLN NKSQPKLMKF AQFEDQLITA DDRSTITVFD WEKGKTLSKF SNGTPFGTKV 240
  241 TDLKLINEDD SALLLTGSSD GVIKIYRDYQ DVDTFKIVSA WRGLTDMLLT PRSTGLLTEW 300
  301 LQIRGSLLTT GDVKVIRVWD AHTETVEVDI PAKTSSLITS LTADQLAGNI FVAGFADGSL 360
  361 RVYDRRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 1k8kC_
Description: Arp2/3 complex 41 kDa subunit ARPC1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [1385-1557] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPRDSMIRRW RAGNDKQGVW INNVHLQRGG YRELVSGATN GVVELWDIRS EDPVESFVDQ  60
   61 NVTSQYGSQQ KPTTMTCMQV HEHAPIIATG TKQIKIWTTS GDLLNSFKNS HNNGVTSTLA 120
  121 ATGIPKSLSY SSTSDAFLSS MAFHPHRMMI AATNSHDSIV NIYKCEDERI DYF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 75.522879
Match: 1gg2B_
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [414-948] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSITTHPMWK SWDLAMDEVL TKIVIDLKNA PPATALESQM ILQQQETLQN GGSSKSNAQD  60
   61 TKAGSIQTQS RFAVANLSTM SLVNNPALQS RKSISLQSSQ QQLQQQQQQQ QQFTGFFEQN 120
  121 LTAFELWLKY ASNVRHPPEQ LPIVLQVLLS QVHRIRALVL LSRFLDLGPW AVYLSLSIGI 180
  181 FPYVLKLLQS PAPELKPILV FIWARIMSID YKNTQSELIK EKGYMYFVTV LVPDWGVNGM 240
  241 SATNGSAMIN SGNPLTMTAS QNINGPSSRY YERQQGNRTS NLGHNNLPFY HSNDTTDEQK 300
  301 AMAVFVLASF VRNFPLGQKN CFSLELVNKL CFYIDNSEIP LLRQWCVILL GLLFADNPLN 360
  361 RFVCMNTGAV EILLKSLKDP VPEVRTASIF ALKHFISGFQ DAEVILRLQQ EFEEQYQQLH 420
  421 SQLQHLQNQS HLQQQQSQQQ QQHLEQQQMK IEKQIRHCQV MQNQLEVIDL RKLKRQEIGN 480
  481 LISILPLIND GSSLVRKELV VYFSHIVSRY SNFFIVVVFN DLLEEIKLLE KSDIN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.26
Match: 1wa5B
Description: Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.53151481871847 bayes_pls_golite062009
protein binding 1.61131270705552 bayes_pls_golite062009
signal transducer activity 1.07458868889742 bayes_pls_golite062009
molecular transducer activity 1.07458868889742 bayes_pls_golite062009
hydrolase activity 0.481485720915241 bayes_pls_golite062009
nucleic acid binding 0.374110439235743 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [949-1029] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRNTSDKYSV SQGSIFYTVW KSLLILAEDP FLENKELSKQ VIDYILLELS AHKELGGPFA  60
   61 VMEKFLLKRS SKAHQTGKFG F

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.42
Match: 1q1sC
Description: Mouse Importin alpha- phosphorylated SV40 CN peptide complex
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1030-1136] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSQVQFVKS SLRSFSPNER VDNNAFKKEQ QQHDPKISHP MRTSLAKLFQ SLGFSESNSD  60
   61 SDTQSSNTSM KSHTSKKGPS GLYLLNGNNN IYPTAETPRF RKHTEPL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 1k8kC
Description: Arp2/3 complex 41 kDa subunit ARPC1
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1137-1557] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLPLNSSFLD YSREYFQEPQ MKKQEADEPG SVEYNARLWR RNRNETIIQE TQGEKKLSIY  60
   61 GNWSKKLISL NNKSQPKLMK FAQFEDQLIT ADDRSTITVF DWEKGKTLSK FSNGTPFGTK 120
  121 VTDLKLINED DSALLLTGSS DGVIKIYRDY QDVDTFKIVS AWRGLTDMLL TPRSTGLLTE 180
  181 WLQIRGSLLT TGDVKVIRVW DAHTETVEVD IPAKTSSLIT SLTADQLAGN IFVAGFADGS 240
  241 LRVYDRRLDP RDSMIRRWRA GNDKQGVWIN NVHLQRGGYR ELVSGATNGV VELWDIRSED 300
  301 PVESFVDQNV TSQYGSQQKP TTMTCMQVHE HAPIIATGTK QIKIWTTSGD LLNSFKNSHN 360
  361 NGVTSTLAAT GIPKSLSYSS TSDAFLSSMA FHPHRMMIAA TNSHDSIVNI YKCEDERIDY 420
  421 F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 76.0
Match: 2ovpB
Description: No description for 2ovpB was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle