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Protein Overview: ARO1

General Information:
Name(s) found: ARO1 / YDR127W [SGD]
Description(s) found:
Found 27 descriptions.
SHOW ALL
  • Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1588 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: aromatic amino acid family biosynthetic process [TAS]
    Molecular Function: shikimate kinase activity [IDALink to PubMed article]
    3-dehydroquinate dehydratase activity [IDALink to PubMed article]
    3-phosphoshikimate 1-carboxyvinyltransferase activity [IDALink to PubMed article]
    3-dehydroquinate synthase activity [IDALink to PubMed article]
    shikimate 5-dehydrogenase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQLAKVPIL GNDIIHVGYN IHDHLVETII KHCPSSTYVI CNDTNLSKVP YYQQLVLEFK  60
   61 ASLPEGSRLL TYVVKPGETS KSRETKAQLE DYLLVEGCTR DTVMVAIGGG VIGDMIGFVA 120
  121 STFMRGVRVV QVPTSLLAMV DSSIGGKTAI DTPLGKNFIG AFWQPKFVLV DIKWLETLAK 180
  181 REFINGMAEV IKTACIWNAD EFTRLESNAS LFLNVVNGAK NVKVTNQLTN EIDEISNTDI 240
  241 EAMLDHTYKL VLESIKVKAE VVSSDERESS LRNLLNFGHS IGHAYEAILT PQALHGECVS 300
  301 IGMVKEAELS RYFGILSPTQ VARLSKILVA YGLPVSPDEK WFKELTLHKK TPLDILLKKM 360
  361 SIDKKNEGSK KKVVILESIG KCYGDSAQFV SDEDLRFILT DETLVYPFKD IPADQQKVVI 420
  421 PPGSKSISNR ALILAALGEG QCKIKNLLHS DDTKHMLTAV HELKGATISW EDNGETVVVE 480
  481 GHGGSTLSAC ADPLYLGNAG TASRFLTSLA ALVNSTSSQK YIVLTGNARM QQRPIAPLVD 540
  541 SLRANGTKIE YLNNEGSLPI KVYTDSVFKG GRIELAATVS SQYVSSILMC APYAEEPVTL 600
  601 ALVGGKPISK LYVDMTIKMM EKFGINVETS TTEPYTYYIP KGHYINPSEY VIESDASSAT 660
  661 YPLAFAAMTG TTVTVPNIGF ESLQGDARFA RDVLKPMGCK ITQTATSTTV SGPPVGTLKP 720
  721 LKHVDMEPMT DAFLTACVVA AISHDSDPNS ANTTTIEGIA NQRVKECNRI LAMATELAKF 780
  781 GVKTTELPDG IQVHGLNSIK DLKVPSDSSG PVGVCTYDDH RVAMSFSLLA GMVNSQNERD 840
  841 EVANPVRILE RHCTGKTWPG WWDVLHSELG AKLDGAEPLE CTSKKNSKKS VVIIGMRAAG 900
  901 KTTISKWCAS ALGYKLVDLD ELFEQQHNNQ SVKQFVVENG WEKFREEETR IFKEVIQNYG 960
  961 DDGYVFSTGG GIVESAESRK ALKDFASSGG YVLHLHRDIE ETIVFLQSDP SRPAYVEEIR1020
 1021 EVWNRREGWY KECSNFSFFA PHCSAEAEFQ ALRRSFSKYI ATITGVREIE IPSGRSAFVC1080
 1081 LTFDDLTEQT ENLTPICYGC EAVEVRVDHL ANYSADFVSK QLSILRKATD SIPIIFTVRT1140
 1141 MKQGGNFPDE EFKTLRELYD IALKNGVEFL DLELTLPTDI QYEVINKRGN TKIIGSHHDF1200
 1201 QGLYSWDDAE WENRFNQALT LDVDVVKFVG TAVNFEDNLR LEHFRDTHKN KPLIAVNMTS1260
 1261 KGSISRVLNN VLTPVTSDLL PNSAAPGQLT VAQINKMYTS MGGIEPKELF VVGKPIGHSR1320
 1321 SPILHNTGYE ILGLPHKFDK FETESAQLVK EKLLDGNKNF GGAAVTIPLK LDIMQYMDEL1380
 1381 TDAAKVIGAV NTVIPLGNKK FKGDNTDWLG IRNALINNGV PEYVGHTAGL VIGAGGTSRA1440
 1441 ALYALHSLGC KKIFIINRTT SKLKPLIESL PSEFNIIGIE STKSIEEIKE HVGVAVSCVP1500
 1501 ADKPLDDELL SKLERFLVKG AHAAFVPTLL EAAYKPSVTP VMTISQDKYQ WHVVPGSQML1560
 1561 VHQGVAQFEK WTGFKGPFKA IFDAVTKE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARO1 HSC82 PFK1 RPA135
    View Details Krogan NJ, et al. (2006) ALA1 ARO1 DUG1 GDH1 HIS4 HIS6 HRD1 MET6 OYE2 RAD14 SCP160 SPE3 SPE4 TIM11 URA6 YLF2 YRB2
    View Details Gavin AC, et al. (2006) AHA1 ARO1 CCT8 PFK1 RAD51 RPS0A SAM1 YHB1
    View Details Gavin AC, et al. (2002) ARO1 ARX1 CCT8 CLU1 CPA2 EMP24 ERP1 ERP2 ERV25 FKS1 GCN20 GFA1 GUS1 HAS1 HHF1, HHF2 HSC82 IDH2 ILV1 KAP123 MKT1 NIP7 PFK1 PHB1 RAD51 RAD52 RFA1 RPA135 RPB2 RPN9 RPT3 RPT6 RRP1 RVB2 YHB1
    View Details Ho Y, et al. (2002) AAC1 AAC3 ADE5,7 AHA1 APT1 ARC1 ARO1 ARP2 ATG11 ATG12 ATG17 BCK1 CAR2 CHS1 CKB2 CMP2 CPA1 CPA2 CPR6 CUE5 CYS4 DBP7 DSS1 ECM10 FET4 GCD11 GFA1 GUS1 HEF3 HOR2 HXT7 IPP1 KOG1 KSP1 LSB3 MTC5 OYE2 PGM2 PPX1 PRB1 PRE1 PRI2 PRP28 PST2 PSY2 PTC7 PUP3 REP1 REX2 RFA3 RHR2 RNQ1 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPT1 RPT3 SEC18 SOD2 SWM1 TCB1 TCB3 TIF1, TIF2 TMA29 TPD3 TPS1 TSA2 TYR1 UBP15 URA7 YFR024C YHR020W YHR033W YJL045W YJR141W YKU80 YLR422W YME2 YNL208W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RBA50 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run BIR1 sample bir 1 from feb 2005 Sandall S, et all (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ARO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..177] PSI-BLAST 1193.0 Dehydroquinate synthase, DHQS
    2 View Details [178..188]
    [204..267]    		 PSI-BLAST 1193.0 Dehydroquinate synthase, DHQS
    3 View Details [189..203]
    [268..401]    		 PSI-BLAST 1193.0 Dehydroquinate synthase, DHQS
    4 View Details [402..423]
    [654..715]
    [854..880]    		 PSI-BLAST 788.9897 No description for 1ln5A_ was found.
    5 View Details [424..653]
    [716..853]    		 PSI-BLAST 788.9897 No description for 1ln5A_ was found.
    6 View Details [881..1057] PSI-BLAST 166.69897 Shikimate kinase (AroK)
    7 View Details [1058..1070]
    [1196..1304]    		 PSI-BLAST 149.07631 Type I 3-dehydroquinate dehydratase
    8 View Details [1071..1195] PSI-BLAST 149.07631 Type I 3-dehydroquinate dehydratase
    9 View Details [1305..1420] Pfam 5.30103 Shikimate / quinate 5-dehydrogenase No confident structure predictions are available.
    10 View Details [1421..1588] PSI-BLAST 8.221849 Glutamyl tRNA-reductase dimerization domain; Glutamyl tRNA-reductase middle domain; Glutamyl tRNA-reductase catalytic, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3-dehydroquinate synthase activity
    		•  2.66599995323323 bayes_pls_golite062009
  • catalytic activity
    		•  2.37357608468991 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.67555894260491 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.60362129760665 bayes_pls_golite062009
  • carbon-oxygen lyase activity, acting on phosphates
    		•  1.17319455535469 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.9498376010104 bayes_pls_golite062009
  • binding
    		•  0.269295154787597 bayes_pls_golite062009
    2
    Term Confidence Notes
  • 3-phosphoshikimate 1-carboxyvinyltransferase activity
    		•  4.55308689407075 bayes_pls_golite062009
  • catalytic activity
    		•  2.54689525592227 bayes_pls_golite062009
  • transferase activity
    		•  2.40426218246544 bayes_pls_golite062009
  • transferase activity, transferring alkyl or aryl (other than methyl) groups
    		•  1.71244782128226 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  1.33437370519308 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.504749089115909 bayes_pls_golite062009
  • nucleotide binding
    		•  0.0579200404644161 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.0495693457499699 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0346567694159108 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0345962863831976 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle