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Protein Overview: YME2

General Information:
Name(s) found: YME2 / YMR302C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 850 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial inner membrane [TASLink to PubMed article]
    Biological Process: rRNA processing [IMPLink to PubMed article]
    mitochondrial genome maintenance [IMPLink to PubMed article]
    Molecular Function: exonuclease activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLVRTTSLN VSRMPVPCLA RGIGILKGKY RLANLMNAQP SVRHVSSEIQ QKDQQAGESN  60
   61 TATDTGVIHK SDEETLIYFD NVYARTTSVW NPTLWYNLLL RNQSRDAVRE KIRNLASPPN 120
  121 NPIYGLELKS TIPVKRDGGV FATFVVPPKY TKAQVNSLIQ QNTARESSKN LLSYFTRASA 180
  181 FPVKGSPWIE DLRRLPSTTI VIKFQGPALT EEEIYSLFRR YGTIIDIFPP TAANNNVAKV 240
  241 RYRSFRGAIS AKNCVSGIEI HNTVLHIQYE NIRRGHLVSN FFTNHTRIAI PVLFALLSIF 300
  301 AVLVFDPIRE FSIEQKITHK YSLSWDNKFW KQLKTLTSST MTSIKYYWGG PDDNHQRKHL 360
  361 WEERIEKVND LKMWLEENNN TFVVIRGPRG SGKHDLVMQH TLQNRANVLY LDCDKLIKSR 420
  421 TDPMFLKNAA SQLGYFPIFP WIDSVTGVLD LTVQGLTGQK TGLSETKESR FRNMLTTSLM 480
  481 SIRRIALKNY KAFVSTGDGT VNVKEEDYLQ QHPEAKPVIV IDRFEGKSEI NGFVYKELSD 540
  541 WAAMLVQMNI AHVIFLTETV ASNQRLSESL PNQVFKNLIL SDASKENSRN YVLSQLEDYL 600
  601 YYNKKSKGEN VKEPESEKET AENNDSDSEA DTSVKKAEVI LNEKELQEID ASLEPLGGRM 660
  661 LDLQAFVRRV KSGEEPSEAV DKMIEQASEQ ITQMFLSDKI DSNKSAQAWE LIELLSANPV 720
  721 IPFHEIVNKP LFKAAPETGI MELENNGLIT VSRDRGVLQE IRPAKPLYRA AFTYLINDPE 780
  781 LAKVLKTRYL LKVVGFETGR IKKWEEELKP LGKVPDQKLF KTRLDYLSGK INASNAVITK 840
  841 CEEEIKNLSK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) DRS1 GAR1 IFH1 NOP1 NPL3 NSR1 POP1 POP2 RAT1 RNT1 RRP3 SBP1 SNM1 SRD1 UTP10 UTP11 UTP13 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9 YME2
    View Details Ho Y, et al. (2002) ARO1 CKB2 CUE5 GDE1 LSB3 PXR1 UBP15 YFR024C YJL045W YLR422W YME2
    View Details Qiu et al. (2008) FZO1 HSP78 NPL3 SBP1 YME2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #16 Mitotic-New search criteria Keck JM, et al. (2011)
    View Run None Entered #18 Mitotic Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YME2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..178] MSA 1.003971 View MSA. No confident structure predictions are available.
    2 View Details [179..336] Pfam 9.552842 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) No confident structure predictions are available.
    3 View Details [337..850] deduced N/A No confident structure predictions are available.
    4 View Details [636..850] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.9031259408875 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49187911603143 bayes_pls_golite062009
  • protein binding
    		•  1.26544376923141 bayes_pls_golite062009
  • RNA binding
    		•  0.772790649151098 bayes_pls_golite062009
  • mRNA binding
    		•  0.0666883120942833 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle