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Protein Overview: FZO1

General Information:
Name(s) found: FZO1 / YBR179C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 855 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: mitochondrial fusion [IMPLink to PubMed article][IPILink to PubMed article]
    mitochondrion organization [TASLink to PubMed article]
    Molecular Function: GTPase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEGKQQFKD SNKPHKDSTD QDDDAATIVP QTLTYSRNEG HFLGSNFHGV TDDRTTLFDG  60
   61 EEGRREDDLL PSLRSSNSKA HLISSQLSQW NYNNNRVLLK RSILKTQAFM DQLQEENNIR 120
  121 PIFIAANDER EKLHVLQLNI KLDGQYNTKE KNGFNIEKKA LSKLFHSQIV SVTNHLNALK 180
  181 KRVDDVSSKV FITGDVNTGK SALCNSLLKQ RLLPEDQLPC TNVFSEILEA RENDGIEEVH 240
  241 AIPLNIAPTL KEAIDMYSIQ NPKTYEIHTL KELPDLVPQN GKYALLKIYI KDDKRPASTS 300
  301 LLRNGTVDIS LIDSPGLNMD SLQTAEVMSR QEEIDLVIFV VNAENQLTLS AKEFISLASR 360
  361 EKKLMFFVVK KFDKIRDKQR CKELILKQIR DLSPETYKRA ADFVHFVSKN GDELPHYHNE 420
  421 NDNEDHGDRK PDDDPYSSSD PDPDFDSLED SLRNFVLKKR SLSKLLPAKT YLSKLLSDII 480
  481 MISKSNMKMY SEEEIKINEQ LETLRPEILS ARAKCNDLTT SVDQMAEQTI TMTYNNTKEA 540
  541 LLNALDVPLH EYPKYQGLGQ IYDFIFSTEA FIANQIDESI GSSELFAKQK TDLLVKKIYE 600
  601 IGKNELGDDF MCERVFRSEL MFRKRKHLIG KRLKVSLSIT DLFAPTWKGF LSYLSWQKPV 660
  661 TAPLPDIEGQ TNEGQIGLMK YLGLKNYPLT QYWSRPSLLF TSKIPTLTLY FLGSTKVVGN 720
  721 IILNGIKLSS WSSLKKLSVP VIVVGSLLGL TYLIHDLPRA LPMNLSIKYK RKLQELDYIH 780
  781 LNAQRTSNEV RDVLRVPTRE ILRSCEIIMD KKQITKKELE NKKESNLLSI KFFQSLYEGT 840
  841 VAQKLMVEEI NLDID

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CCT2 CCT3 CCT5 CCT6 FZO1 MYO2 NEW1 PEX7 RPN6 UBR1
    View Details Qiu et al. (2008) FZO1 MGM1 YME2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FZO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] deduced N/A No confident structure predictions are available.
    2 View Details [129..543] PSI-BLAST 42.39794 Dynamin G domain
    3 View Details [544..695] MSA 3.163995 View MSA. No confident structure predictions are available.
    4 View Details [696..855] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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