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View Structure Prediction Details

Protein: FZO1
Organism: Saccharomyces cerevisiae
Length: 855 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FZO1.

Description E-value Query
Range
Subject
Range
FZO1 - Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondria...
FZO1_YEAST - Mitofusin FZO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FZO1 PE=1 SV=1
0.0 [1..855] [1..855]
fzo1 - mitochondrial fusion GTPase protein
FZO1_SCHPO - Transmembrane GTPase fzo1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fzo1 PE=3 SV=1
0.0 [59..853] [14..752]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [80..853] [2..700]
gi|123230379 - gi|123230379|emb|CAM15857.1| dynamin 1 [Mus musculus]
DYN1_RAT - Dynamin-1 - Rattus norvegicus (Rat)
2.0E-72 [169..648] [13..436]
gi|29789169, gi|... - gi|29789169|ref|NP_077162.1| mitofusin 1 [Mus musculus], gi|12857783|dbj|BAB31111.1| unnamed protein...
9.0E-70 [120..643] [6..532]
MX1 - myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
2.0E-69 [138..633] [18..503]

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Predicted Domain #1
Region A:
Residues: [1-128]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEGKQQFKD SNKPHKDSTD QDDDAATIVP QTLTYSRNEG HFLGSNFHGV TDDRTTLFDG  60
   61 EEGRREDDLL PSLRSSNSKA HLISSQLSQW NYNNNRVLLK RSILKTQAFM DQLQEENNIR 120
  121 PIFIAAND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [129-543]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EREKLHVLQL NIKLDGQYNT KEKNGFNIEK KALSKLFHSQ IVSVTNHLNA LKKRVDDVSS  60
   61 KVFITGDVNT GKSALCNSLL KQRLLPEDQL PCTNVFSEIL EARENDGIEE VHAIPLNIAP 120
  121 TLKEAIDMYS IQNPKTYEIH TLKELPDLVP QNGKYALLKI YIKDDKRPAS TSLLRNGTVD 180
  181 ISLIDSPGLN MDSLQTAEVM SRQEEIDLVI FVVNAENQLT LSAKEFISLA SREKKLMFFV 240
  241 VKKFDKIRDK QRCKELILKQ IRDLSPETYK RAADFVHFVS KNGDELPHYH NENDNEDHGD 300
  301 RKPDDDPYSS SDPDPDFDSL EDSLRNFVLK KRSLSKLLPA KTYLSKLLSD IIMISKSNMK 360
  361 MYSEEEIKIN EQLETLRPEI LSARAKCNDL TTSVDQMAEQ TITMTYNNTK EALLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.39794
Match: 1jwyB_
Description: Dynamin G domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [544-695]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALDVPLHEYP KYQGLGQIYD FIFSTEAFIA NQIDESIGSS ELFAKQKTDL LVKKIYEIGK  60
   61 NELGDDFMCE RVFRSELMFR KRKHLIGKRL KVSLSITDLF APTWKGFLSY LSWQKPVTAP 120
  121 LPDIEGQTNE GQIGLMKYLG LKNYPLTQYW SR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [696-855]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSLLFTSKIP TLTLYFLGST KVVGNIILNG IKLSSWSSLK KLSVPVIVVG SLLGLTYLIH  60
   61 DLPRALPMNL SIKYKRKLQE LDYIHLNAQR TSNEVRDVLR VPTREILRSC EIIMDKKQIT 120
  121 KKELENKKES NLLSIKFFQS LYEGTVAQKL MVEEINLDID 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle