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Protein Overview: POP1

General Information:
Name(s) found: POP1 / YNL221C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 875 amino acids

    Gene Ontology:
    Cellular Component: ribonuclease MRP complex [IDALink to PubMed article]
    nucleolar ribonuclease P complex [IDALink to PubMed article]
    Biological Process: tRNA processing [TASLink to PubMed article]
    rRNA processing [IPILink to PubMed article]
    mRNA cleavage [IPILink to PubMed article]
    Molecular Function: ribonuclease P activity [IMPLink to PubMed article]
    ribonuclease MRP activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSLSRGNG GKKVLNKNQL LKRNRIRNAR SIRAEAVAAS STKTGTPSDL SESGSKLNVD  60
   61 QFISSRQFEV KQLQLAMHNS KAASSTRIFQ ALPRKLRRRT ASHNVRRIPK RMRNRALREM 120
  121 RKSDQQDVLK GSSASSRKAH GLNAKQLYKA RMSIKLLRLA SKSTSMKLSM PPEVTSSNCH 180
  181 VRQKIKTLKR MIKESSTANP NIKLLNNRMG SYDCTGVNEL APIPKGRVKY TKRQKHFAWL 240
  241 PTHIWNAKRS HMMKRWGYQM VWAPTQKCFK LTHRLGGDTC SSDGALCMDS SYIGTIIVKD 300
  301 KSNDSEGDFL KSIIGKLTAE RANLRKYREG QVLFQGLIYS FNEENGEDST KPLGPCDVFW 360
  361 VQKDTAIIRL HPSIYTQVFN ILLQHKEKLT VQDCRYSLAS VTLKGAKALE SLASCLRSTE 420
  421 YSKSFEQFKM VSMITDHNAL PQRCTFAFEA IDPRHLAAPK KLNDSQRKTV NSDDILSLHE 480
  481 NYPQDEINAV FNELCDPESR TQSYNNQNTL KEISARRYKL LTATPNSINK TTVPFKESDD 540
  541 PSIPLVIIRR LKTRDWIVVL PWFWLLPLWH LLNRIPRMYH IGLRQFQQIQ YENKQLYFPD 600
  601 DYPFTQLGYI ENSFYKKEAS KTKWDRKPMG KRINFEKIKD IHNTKLPAYS GEIGDFFSSD 660
  661 WRFLQILRNG IDYLQRNDKT LELMDSKKTG QFNAQGVRDI NCVNDVLEFC KDYEAKTKAM 720
  721 SLSIEENIPV ALCKNRKCQF RTPDSISVNS SSFSLTFFPR CIIAVSCTLL ERGHPKDNAR 780
  781 IYQVPEKDLE HWLQLAKGVY RPNGRKDHDL KIPLPEVHDL IGFITSGTYH LNCGNGMGIG 840
  841 FIDHHAAIRQ PTRYVLIRNV GTNTYRLGEW SKISV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) POP1 POP3 POP4 POP5 POP8 RPP1
    View Details Hazbun TR, et al. (2003) POP1 POP3 POP4 POP5 POP6 POP8 RMP1 RPP1 SNM1
    View Details (MIPS) Mewes HW, et al. (2004) DRS1 GAR1 IFH1 NOP1 NPL3 NSR1 POP1 POP2 POP3 POP4 POP5 POP6 POP7 POP8 RAT1 RNT1 RPP1 RPR2 RRP3 SBP1 SNM1 SRD1 UTP10 UTP11 UTP13 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9 YME2
    View Details Krogan NJ, et al. (2006) POP1 POP3 POP4 POP5 POP6 POP7 RMP1 RPP1 RPR2 SNM1
    View Details Gavin AC, et al. (2006) POP1 POP3 POP4 POP5 POP8 RPP1
    View Details Gavin AC, et al. (2002) POP1 POP3 POP4 POP5 POP6 POP8 RPP1
    View Details Qiu et al. (2008) DBP7 DRS1 GAR1 HCA4 IFH1 MAK5 MTR4 NOP1 POP1 POP3 POP4 POP5 POP6 POP7 POP8 RMP1 RNT1 RPP1 RPR2 RRP3 SNM1 UTP6 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RMP1 No Comments Hazbun TR, et al. (2003)
    View Run RMP1 No Comments Hazbun TR, et al. (2003)
    View Run RMP1 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data POP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..125] MSA 2.005988 View MSA. No confident structure predictions are available.
    2 View Details [126..353] deduced N/A No confident structure predictions are available.
    3 View Details [354..800] MSA 2.006881 View MSA. No confident structure predictions are available.
    4 View Details [801..875] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • methyltransferase activity
    		•  1.83230066187063 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  1.757479064419 bayes_pls_golite062009
  • catalytic activity
    		•  1.52741791343033 bayes_pls_golite062009
  • binding
    		•  1.07222887529954 bayes_pls_golite062009
  • transferase activity
    		•  0.0529926681035639 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle