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Protein Overview: UTP4

General Information:
Name(s) found: UTP4 / YDR324C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 776 amino acids

    Gene Ontology:
    Cellular Component: small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: maturation of SSU-rRNA [IMPLink to PubMed article][IPILink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: snoRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSLLSVLK EKSRSLKIRN KPVKMTSQER MIVHRCRFVD FTPATITSLA FSHKSNINKL  60
   61 TPSDLRLAIG RSNGNIEIWN PRNNWFQEMV IEGGKDRSIE GLCWSNVNGE SLRLFSIGGS 120
  121 TVVTEWDLAT GLPLRNYDCN SGVIWSISIN DSQDKLSVGC DNGTVVLIDI SGGPGVLEHD 180
  181 TILMRQEARV LTLAWKKDDF VIGGCSDGRI RIWSAQKNDE NMGRLLHTMK VDKAKKESTL 240
  241 VWSVIYLPRT DQIASGDSTG SIKFWDFQFA TLNQSFKAHD ADVLCLTTDT DNNYVFSAGV 300
  301 DRKIFQFSQN TNKSQKNNRW VNSSNRLLHG NDIRAICAYQ SKGADFLVSG GVEKTLVINS 360
  361 LTSFSNGNYR KMPTVEPYSK NVLVNKEQRL VVSWSESTVK IWTMGTDSST EQNYKLVCKL 420
  421 TLKDDQNIST CSLSPDGQVL VVGRPSTTKV FHLQPVGNKL KVTKLDNDLL LRTSTKLVKF 480
  481 IDNSKIVICS CEDDVFIVDL ESEEDEKPQE VELLEVTSTK SSIKVPYINR INHLEVDQNI 540
  541 AVISRGCGVV DILDLKARIS KPLARLNNFI TAVHINTSRK SVVVITADNK IYEFNMNLNS 600
  601 EAENEDSESV LTQWSKNNTD NLPKEWKTLK ENCVGIFSDI ENSSRLWFWG ATWISRIDFD 660
  661 VDFPINKRRK QKKRTHEGLT ITDESNFMND EEDDEDDDID MEISENLNVL LNQGNKIKST 720
  721 DVQRNEESSG HFFFTDKYKP LLFVDLISSN ELAIIERNPL TFHSKQKAFI QPKLVF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BMS1 DIM1 DIP2 ECM16 EMG1 ENP1 ENP2 IMP3 KRE33 MPP10 NAN1 NOC4 NOP1 NOP14 NOP56 PNO1 POL5 PWP2 RPS13 RRP9 SOF1 UTP10 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9
    View Details (MIPS) Mewes HW, et al. (2004) DRS1 GAR1 IFH1 NOP1 NPL3 NSR1 POP1 POP2 RAT1 RNT1 RRP3 SBP1 SNM1 SRD1 UTP10 UTP11 UTP13 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9 YME2
    View Details Krogan NJ, et al. (2006) GFD2 NAN1 POL5 UTP10 UTP15 UTP4 UTP5 UTP8 UTP9
    View Details Gavin AC, et al. (2006) CDC60 CMS1 DIP2 MRD1 NAN1 NOP58 PNO1 PWP2 ROK1 RRP9 UTP10 UTP13 UTP15 UTP18 UTP21 UTP22 UTP4 UTP6 UTP7 UTP8 UTP9
    View Details Gavin AC, et al. (2002) ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PFS2 PNO1 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 RCL1 REF2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SOF1 SRO9 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YOR059C YSH1
    View Details Ho Y, et al. (2002) CDC10 HHF1, HHF2 HTB1 HTB2 INO4 MAM33 MSI1 NIP7 PSE1 RAD1 UTP4
    View Details Qiu et al. (2008) BFR2 BRX1 BUD21 DBP3 DBP6 DBP7 DBP8 DHR2 DIP2 DRS1 ECM16 ENP1 ERB1 GAR1 HCA4 IMP3 JIP5 KRI1 KRR1 MAK11 MAK5 MRD1 MRT4 MTR4 NAN1 NOP1 NOP12 NOP13 NOP15 NOP2 NOP4 NOP7 NSR1 PWP2 PXR1 RNT1 RRB1 RRP5 RRP9 SAS10 SGD1 SNU13 SOF1 SPB4 UTP10 UTP11 UTP13 UTP14 UTP15 UTP18 UTP20 UTP22 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ESF1 No Comments Hazbun TR, et al. (2003)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data UTP4 and SPC42 Unpublished Data
    View Data UTP4 Huh WK, et al. (2003)
    View Data UTP4 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..73] deduced N/A No confident structure predictions are available.
    2 View Details [74..166] PSI-BLAST 79.30103 beta1-subunit of the signal-transducing G protein heterotrimer
    3 View Details [167..504] PSI-BLAST 96.24799 Tup1, C-terminal domain
    4 View Details [505..692] MSA 3.485995 View MSA. No confident structure predictions are available.
    5 View Details [693..776] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • snoRNA binding
    		•  6.03079504484743 bayes_pls_golite062009
    		• 3.41022148055944 bayes_pls_golite062009
  • RNA binding
    		•  3.0829625416797 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.5283366007575 bayes_pls_golite062009
  • structural molecule activity
    		•  1.31060431370834 bayes_pls_golite062009
  • transcription activator activity
    		•  1.23969853550045 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • actin binding
    		•  0.794986868016276 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.658573452658359 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • ligase activity
    		•  0.280267687917718 bayes_pls_golite062009
  • tubulin binding
    		•  0.194781260474147 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.182612389752591 bayes_pls_golite062009
  • microtubule binding
    		•  0.167936232702449 bayes_pls_golite062009
  • mRNA binding
    		•  0.0519838181830878 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle