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Protein Overview: NOP13

General Information:
Name(s) found: NOP13 / YNL175C [SGD]
Description(s) found:
Found 20 descriptions.
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  • Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 403 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    nucleoplasm [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: RNA binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSETELSKED AVTKKDNEEQ VKKALLDPTK KRKAEDEIEI DLKSSIPLSK KQKRLLRRGK  60
   61 VTLEELNAKY NIDPKSIEEY KEDAEKKKSG ASEKDAQGEE STINTPTGDE SGEVVKKKKK 120
  121 DENKYGVWIG NLSFDTTKDD LVRFFIAKTK DNEDEKSRVT EQDITRLSMP RVAAKNSNAM 180
  181 KNKGFCYMFF KNVEQMKAVL ELSESHLNGR NMLIKDSENY SGRPDKDDLV AMSKNPPSRI 240
  241 LFVGNLSFDV TDDLLRKHFQ HCGDIVKIRM ATFEDSGKCK GFAFIDFKNE EGSTNELKDK 300
  301 SCRKIAGRPL RMEYGEDRSK RQVRKKVENV SRNNSSSFDI SNNKGYDRAG QDNGSKPEYK 360
  361 RSNANRRPPV DSNNRTKSSV ALATAQRGSA AIVPSQGKKV KFD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AEP3 CDC20 FAB1 FOL2 GZF3 LSP1 NOP13 PIL1 PKH1 PRP16 PSK2 RGC1 RPL9B YLR179C YMR086W YTA6
    View Details Gavin AC, et al. (2006) DBP10 DBP9 FPR4 NOP13 NOP4 PUF6 RIX7 RLP7
    View Details Ho Y, et al. (2002) AFG2 ALB1 ARX1 BUD20 CDC5 CIC1 DBP7 DRS1 EBP2 EHD3 FYV4 HHF1, HHF2 HTA1 HTB1 HTB2 IMD2 IMD3 IRR1 IVY1 KAP95 KRI1 LHP1 MAM33 MCD1 MNP1 MRPS16 MSS116 NMD3 NOC2 NOG1 NOP12 NOP13 NOP4 NOP7 NSA2 NUG1 PRP43 PUF6 PWP1 RIX1 RRP5 RSM24 RSM25 SMC1 SMC3 SPC72 SRP1 TIF4631 YBL044W
    View Details Qiu et al. (2008) CIC1 DBP2 DBP3 DBP7 DHR2 DRS1 FPR4 GAR1 KRR1 MAK5 MRT4 NOP12 NOP13 NOP15 NOP4 NSR1 NUG1 PRP43 RNT1 RPL15B RPL27A RPL7B RRP9 SPB4 UTP10 UTP13 UTP15 UTP4 UTP5 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NOP13 Huh WK, et al. (2003)
    View Data NOP13 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] PSI-BLAST 75.218487 Poly(A)-binding protein
    2 View Details [113..227] PSI-BLAST 113.512579 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    3 View Details [228..328] PSI-BLAST 113.512579 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    4 View Details [329..403] PSI-BLAST 34.39794 Sex-lethal protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.04120049976231 bayes_pls_golite062009
  • mRNA binding
    		•  4.29904003387927 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
    		• 3.36965439092178 bayes_pls_golite062009
  • binding
    		•  3.05116833253954 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.32565125258004 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  1.99190411806363 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • protein binding
    		•  0.89093640300829 bayes_pls_golite062009
  • snoRNA binding
    		•  0.87536768969411 bayes_pls_golite062009
  • snRNA binding
    		•  0.45487108214667 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
    2
    Term Confidence Notes
  • RNA binding
    		•  6.04120049976231 bayes_pls_golite062009
  • mRNA binding
    		•  4.29904003387927 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
    		• 3.36965439092178 bayes_pls_golite062009
  • binding
    		•  3.05116833253954 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.32565125258004 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  1.99190411806363 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • protein binding
    		•  0.89093640300829 bayes_pls_golite062009
  • snoRNA binding
    		•  0.87536768969411 bayes_pls_golite062009
  • snRNA binding
    		•  0.45487108214667 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle