YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: FAB1

General Information:
Name(s) found: FAB1 / YFR019W [SGD]
Description(s) found:
Found 14 descriptions.
SHOW ALL
  • 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2278 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    late endosome [IDALink to PubMed article]
    vacuolar membrane [IDALink to PubMed article]
    vacuole [IDALink to PubMed article]
    Biological Process: vacuole organization [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    late endosome to vacuole transport [IMPLink to PubMed article]
    phospholipid metabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    negative regulation of transcription from RNA polymerase II promoter by glucose [IMPLink to PubMed article]
    Golgi to vacuole transport [IMPLink to PubMed article]
    Molecular Function: 1-phosphatidylinositol-3-phosphate 5-kinase activity [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    phosphatidylinositol-3-phosphate binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEEPHASI SFPDGSHVRS SSTGTSSVNT IDATLSRPNY IKKPSLHIMS TSTTSTTTDL  60
   61 VTNPILSNIS VPKISPPTSS SIATATSTSH VTGTASHSNI KANANTSTSV NKKNLPPTTS 120
  121 GRIPSSTIKR YPSRYKPSHS LQLPIKNDSN FKRSSIYASK STVTAIPIRN NRPISMQNSY 180
  181 ARTPDSDHDD VGDEVSSIKS ASSSLTASLS KSFLFAFYNN RKKDKTSNNG VLSKEYWMKD 240
  241 ESSKECFSCG KTFNTFRRKH HCRICGQIFC SSCTLLIDGD RFGCHAKMRV CYNCYEHADT 300
  301 YEDSSDEEND STMQLNEPRS RSRSRSSNTN PYSHSHSHLH LISQDNHNGT DLHDPVAATD 360
  361 NPQQQNEVYL LNDDDVQSIM TSGEDSKLFI STPPPPPKMA IPATKQGGSL EISFDSENDR 420
  421 ALHYQDDNPG RHHHLDSVPT RYTIRDMDNI SHYDTNSNST LRPHYNTNNS TITINNLNNT 480
  481 TSNNSNYNNT NSNSNINNPA HSLRRSIFHY VSSNSVNKDS NNSSATPASS AQSSSILDPA 540
  541 NRIIGNYAHR NYKFKFNYNS KGPSQQNDTA NGNNDNNNNN NNNNNNNNNN SASGIADNNN 600
  601 IPSNDNGTTF TLDKKKRNPL TKSKSTSAYL EYPLNEEDSS EDEGSMSIYS VLNDDHKTDN 660
  661 PIRSMRNSTK SFQRAQASLQ RMRFRRKSKS KHFPNNSKSS IYRDLNFLTN STPNLLSVVS 720
  721 DDNLYDDSSP LQDKASSSAA SRLTDRKFSN SSGSNNNSNS NSNINTDPWK RIASISGFKL 780
  781 KKEKKRELNE VSLLHMHALL KQLLNDQEIS NLQEWITLLD GALRKVLRTI LNARDLNTLD 840
  841 FRQTYVKIKR ISGGSPQNSE YIDGVVFSKA LPSKTMPRHL KNPRILLIMF PLEYQKNNNH 900
  901 FLSIESVFRQ EREYLDKLVS RLKSLHPDII YVGANVSGYA LELLNDSGIV VQFNMKPQVI 960
  961 ERIAKLTEAD IAISVDKLAT NIKMGECETF EVKSYIYGNI SKTYTFLRGC NPELGGTILL1020
 1021 RGDSLENLRK IKQVSEFMVY AIFSLKLESS FFNDNFIQLS TDVYLKRAES KKLQVFEGYF1080
 1081 ADFLIKFNNR ILTVSPTVDF PIPFLLEKAR GLEKKLIERI NQYESESDLD RQTQLNMLQG1140
 1141 LESTITKKHL GNLIKFLHEM EIENLELEFQ KRSRQWEVSY SSSQNLLGTG SHQSITVLYS1200
 1201 MVSTKTATPC VGPQIVTIDY FWDSDISIGQ FIENVVGTAR YPCQQGCNGL YLDHYRSYVH1260
 1261 GSGKVDVLIE KFQTRLPKLK DIILTWSYCK KCGTSTPILQ ISEKTWNHSF GKYLEVMFWS1320
 1321 YKDSVTGIGK CPHDFTKDHV KYFGYNDLVV RLEYSDLEVH ELITPPRKIK WKPHIDIKLK1380
 1381 VELYYKILEK INNFYGSVLS RLERIKLDSM TKDKVLSGQA KIIELKSNAT EEQKLMLQDL1440
 1441 DTFYADSPCD QHLPLNLVIK SLYDKAVNWN STFAIFAKSY LPSETDISRI TAKQLKKLFY1500
 1501 DSSRKDSEDK KSLHDEKAKT RKPEKNELPL EGLKDVEKPK IDSKNTTENR DRTNEPQNAV1560
 1561 TITTFKDDTP IIPTSGTSHL TVTPSASSVS SSLTPQTEER PPISRSGTGI SMTHDKSTRP1620
 1621 NIRKMSSDSS LCGLASLANE YSKNNKVSKL ATFFDQMHFD ALSKEFELER ERERLQLNKD1680
 1681 KYQAIRLQTS TPIVEIYKNV KDAVDEPLHS RSSGNNLSSA NVKTLEAPVG EHSRANNCNP1740
 1741 PNLDQNLETE LENSISQWGE NILNPSGKTT ASTHLNSKPV VKETSENPKS IVRESDNSKS1800
 1801 EPLPPVITTT TVNKVESTPQ PEKSLLMKTL SNFWADRSAY LWKPLVYPTC PSEHIFTDSD1860
 1861 VIIREDEPSS LIAFCLSTSD YRNKMMNLNV QQQQQQQTAE AAPAKTGGNS GGTTQTGDPS1920
 1921 VNISPSVSTT SHNKGRDSEI SSLVTTKEGL LNTPPIEGAR DRTPQESQTH SQANLDTLQE1980
 1981 LEKIMTKKTA THLRYQFEEG LTVMSCKIFF TEHFDVFRKI CDCQENFIQS LSRCVKWDSN2040
 2041 GGKSGSGFLK TLDDRFIIKE LSHAELEAFI KFAPSYFEYM AQAMFHDLPT TLAKVFGFYQ2100
 2101 IQVKSSISSS KSYKMDVIIM ENLFYEKKTT RIFDLKGSMR NRHVEQTGKA NEVLLDENMV2160
 2161 EYIYESPIHV REYDKKLLRA SVWNDTLFLA KMNVMDYSLV IGIDNEGYTL TVGIIDFIRT2220
 2221 FTWDKKLESW VKEKGLVGGA SVIKQPTVVT PRQYKKRFRE AMERYILMVP DPWYWEGN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AEP3 CDC20 FAB1 FOL2 GZF3 LSP1 NOP13 PIL1 PKH1 PRP16 PSK2 RGC1 RPL9B YLR179C YMR086W YTA6
    View Details Gavin AC, et al. (2002) ACC1 ADA2 ADH1 AVT4 BEM2 CCT2 CDC25 COG3 CSE2 ENO2 FAB1 FBA1 GAL11 GCN5 HRK1 MDS3 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MIA40 MLP1 MRPL3 MRPL6 NUT1 NUT2 PGD1 PGK1 RGR1 ROX3 RPG1 RPO21 SAP155 SAP185 SAP190 SIN4 SIT4 SPT7 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SSE2 SSN2 SSN3 SSN8 SWT21 TAF6 TIF1, TIF2 YIL077C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data FAB1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] MSA 3.036995 View MSA. No confident structure predictions are available.
    2 View Details [130..223] deduced N/A No confident structure predictions are available.
    3 View Details [224..318] PSI-BLAST 93.014858 Eea1
    4 View Details [319..621] deduced N/A No confident structure predictions are available.
    5 View Details [622..767]
    [793..1053]
    [1147..1245]    		 PSI-BLAST 266.9794 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
    6 View Details [768..792]
    [1054..1146]    		 PSI-BLAST 266.9794 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
    7 View Details [1246..1556] deduced N/A No confident structure predictions are available.
    8 View Details [1557..1906] MSA 1.023926 View MSA. No confident structure predictions are available.
    9 View Details [1907..2207] PSI-BLAST 180.325697 Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
    10 View Details [2208..2278] ORFEUS 9.06 Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
    11 View Details [1834..1938] deduced N/A No confident structure predictions are available.
    12 View Details [1939..2207] PSI-BLAST 87.154902 Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
    13 View Details [2208..2278] FFAS03 3.05 No description for 2gk9A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.91198418028463 bayes_pls_golite062009
  • hydrolase activity
    		•  1.6496873637792 bayes_pls_golite062009
  • phospholipid binding
    		•  1.59925226936355 bayes_pls_golite062009
  • protein binding
    		•  1.48509567539584 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.23051397099487 bayes_pls_golite062009
  • phosphatidylinositol binding
    		•  0.89007551328268 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.578667797495151 bayes_pls_golite062009
  • kinase activity
    		•  0.5474180136682 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.434348342855481 bayes_pls_golite062009
  • protein kinase activity
    		•  0.433946621843553 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.374880899986848 bayes_pls_golite062009
  • DNA binding
    		•  0.305675266889943 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.124968144864745 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • hydrolase activity
    		•  2.63310249451671 bayes_pls_golite062009
  • protein binding
    		•  2.09735210528305 bayes_pls_golite062009
  • binding
    		•  2.08998371530415 bayes_pls_golite062009
  • 1-phosphatidylinositol-4-phosphate 5-kinase activity
    		•  2.0792241139321 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.96238696659825 bayes_pls_golite062009
  • lipid kinase activity
    		•  1.30654443346559 bayes_pls_golite062009
  • phosphatidylinositol phosphate kinase activity
    		•  1.1532371074226 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  0.957759029487778 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.609181214178764 bayes_pls_golite062009
  • kinase activity
    		•  0.56493424031677 bayes_pls_golite062009
  • ATP binding
    		•  0.5099076331221 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.476997431498572 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.464268634351039 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.374469998972096 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.248824655860947 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.246179970580854 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.241253051624856 bayes_pls_golite062009
  • nucleotide binding
    		•  0.238397494027434 bayes_pls_golite062009
  • catalytic activity
    		•  0.107125378994589 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12
    Term Confidence Notes
  • 1-phosphatidylinositol-4-phosphate 5-kinase activity
    		•  4.78387945404586 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  4.31726963575315 bayes_pls_golite062009
  • lipid kinase activity
    		•  3.63026201392483 bayes_pls_golite062009
  • phosphatidylinositol phosphate kinase activity
    		•  3.5005619620026 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.8512866333787 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.80917598973106 bayes_pls_golite062009
  • kinase activity
    		•  2.68971389233526 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.31077377326314 bayes_pls_golite062009
  • catalytic activity
    		•  1.87792712964225 bayes_pls_golite062009
  • transferase activity
    		•  1.20817067352467 bayes_pls_golite062009
  • ligase activity
    		•  1.05123871944442 bayes_pls_golite062009
  • binding
    		•  0.64375712515604 bayes_pls_golite062009
  • protein binding
    		•  0.444571506795422 bayes_pls_golite062009
  • protein kinase activity
    		•  0.422676745032915 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.189737258618863 bayes_pls_golite062009
    13 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle