YRC Public Data Repository - Protein Structure Prediction

Protein:	FAB1
Organism:	Saccharomyces cerevisiae
Length:	2278 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FAB1.

Description	E-value	Query Range	Subject Range
FAB1 - 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylino... FAB1_YEAST - 1-phosphatidylinositol 3-phosphate 5-kinase FAB1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...	0.0	[1..2278]	[1..2278]
gi\|14571648 - gi\|14571648\|emb\|CAC42810.1\| phosphatidylinositol 3,5-kinase [Candida albicans]	0.0	[20..1711]	[18..1840]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[426..1607]	[123..1332]
FAB1C_ARATH - Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C OS=Arabidopsis thaliana GN=FAB1C PE=2 SV=...	0.0	[601..1567]	[139..1144]
THSB_ARCFU - Thermosome subunit beta OS=Archaeoglobus fulgidus GN=thsB PE=3 SV=1 THSB_ARCFU - Thermosome subunit beta OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 /...	0.0	[672..1176]	[5..525]
gi\|18978346, gi\|... - gi\|18978346\|ref\|NP_579703.1\| thermosome, single subunit [Pyrococcus furiosus DSM 3638], gi\|18894178\|...	0.0	[672..1177]	[5..526]
THSB_PYRKO - Thermosome subunit beta OS=Pyrococcus kodakaraensis GN=thsB PE=3 SV=1 THSB_THEKO - Thermosome subunit beta OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=ths... gi\|473965, gi\|21... - gi\|473965\|dbj\|BAA06143.1\| heat-shock protein [Pyrococcus sp.], pir\|\|S61294 heat-shock protein - Pyro...	0.0	[672..1174]	[5..523]
THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain KS-1) GN=thsB PE=3 SV=2 THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=thsB PE=3 SV=2	0.0	[672..1174]	[5..523]
THS_PYRHO - Thermosome subunit OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139... THS_PYRHO - Thermosome subunit OS=Pyrococcus horikoshii GN=ths PE=3 SV=1	0.0	[672..1175]	[5..524]

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Predicted Domain #1

Region A:
Residues: [1-129]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEEPHASI SFPDGSHVRS SSTGTSSVNT IDATLSRPNY IKKPSLHIMS TSTTSTTTDL  60
   61 VTNPILSNIS VPKISPPTSS SIATATSTSH VTGTASHSNI KANANTSTSV NKKNLPPTTS 120
  121 GRIPSSTIK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [130-223]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYPSRYKPSH SLQLPIKNDS NFKRSSIYAS KSTVTAIPIR NNRPISMQNS YARTPDSDHD  60
   61 DVGDEVSSIK SASSSLTASL SKSFLFAFYN NRKK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	1.91198418028463	bayes_pls_golite062009
hydrolase activity	1.6496873637792	bayes_pls_golite062009
phospholipid binding	1.59925226936355	bayes_pls_golite062009
protein binding	1.48509567539584	bayes_pls_golite062009
phosphoinositide binding	1.23051397099487	bayes_pls_golite062009
phosphatidylinositol binding	0.89007551328268	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.578667797495151	bayes_pls_golite062009
kinase activity	0.5474180136682	bayes_pls_golite062009
nucleic acid binding	0.434348342855481	bayes_pls_golite062009
protein kinase activity	0.433946621843553	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.374880899986848	bayes_pls_golite062009
DNA binding	0.305675266889943	bayes_pls_golite062009
transcription regulator activity	0.124968144864745	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [224-318]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKTSNNGVLS KEYWMKDESS KECFSCGKTF NTFRRKHHCR ICGQIFCSSC TLLIDGDRFG  60
   61 CHAKMRVCYN CYEHADTYED SSDEENDSTM QLNEP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	93.014858
Match:	1hyiA_
Description:	Eea1
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [319-621]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSRSRSRSSN TNPYSHSHSH LHLISQDNHN GTDLHDPVAA TDNPQQQNEV YLLNDDDVQS  60
   61 IMTSGEDSKL FISTPPPPPK MAIPATKQGG SLEISFDSEN DRALHYQDDN PGRHHHLDSV 120
  121 PTRYTIRDMD NISHYDTNSN STLRPHYNTN NSTITINNLN NTTSNNSNYN NTNSNSNINN 180
  181 PAHSLRRSIF HYVSSNSVNK DSNNSSATPA SSAQSSSILD PANRIIGNYA HRNYKFKFNY 240
  241 NSKGPSQQND TANGNNDNNN NNNNNNNNNN NNSASGIADN NNIPSNDNGT TFTLDKKKRN 300
  301 PLT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [622-767]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSKSTSAYLE YPLNEEDSSE DEGSMSIYSV LNDDHKTDNP IRSMRNSTKS FQRAQASLQR  60
   61 MRFRRKSKSK HFPNNSKSSI YRDLNFLTNS TPNLLSVVSD DNLYDDSSPL QDKASSSAAS 120
  121 RLTDRKFSNS SGSNNNSNSN SNINTD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [793-1053]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLHMHALLKQ LLNDQEISNL QEWITLLDGA LRKVLRTILN ARDLNTLDFR QTYVKIKRIS  60
   61 GGSPQNSEYI DGVVFSKALP SKTMPRHLKN PRILLIMFPL EYQKNNNHFL SIESVFRQER 120
  121 EYLDKLVSRL KSLHPDIIYV GANVSGYALE LLNDSGIVVQ FNMKPQVIER IAKLTEADIA 180
  181 ISVDKLATNI KMGECETFEV KSYIYGNISK TYTFLRGCNP ELGGTILLRG DSLENLRKIK 240
  241 QVSEFMVYAI FSLKLESSFF N

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [1147-1245]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKHLGNLIKF LHEMEIENLE LEFQKRSRQW EVSYSSSQNL LGTGSHQSIT VLYSMVSTKT  60
   61 ATPCVGPQIV TIDYFWDSDI SIGQFIENVV GTARYPCQQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	266.9794
Match:	1a6dA_
Description:	Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	2.63310249451671	bayes_pls_golite062009
protein binding	2.09735210528305	bayes_pls_golite062009
binding	2.08998371530415	bayes_pls_golite062009
1-phosphatidylinositol-4-phosphate 5-kinase activity	2.0792241139321	bayes_pls_golite062009
unfolded protein binding	1.96238696659825	bayes_pls_golite062009
lipid kinase activity	1.30654443346559	bayes_pls_golite062009
phosphatidylinositol phosphate kinase activity	1.1532371074226	bayes_pls_golite062009
inositol or phosphatidylinositol kinase activity	0.957759029487778	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.609181214178764	bayes_pls_golite062009
kinase activity	0.56493424031677	bayes_pls_golite062009
ATP binding	0.5099076331221	bayes_pls_golite062009
adenyl ribonucleotide binding	0.476997431498572	bayes_pls_golite062009
adenyl nucleotide binding	0.464268634351039	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.374469998972096	bayes_pls_golite062009
ribonucleotide binding	0.248824655860947	bayes_pls_golite062009
purine ribonucleotide binding	0.246179970580854	bayes_pls_golite062009
purine nucleotide binding	0.241253051624856	bayes_pls_golite062009
nucleotide binding	0.238397494027434	bayes_pls_golite062009
catalytic activity	0.107125378994589	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [768-792]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PWKRIASISG FKLKKEKKRE LNEVS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1054-1146]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNFIQLSTDV YLKRAESKKL QVFEGYFADF LIKFNNRILT VSPTVDFPIP FLLEKARGLE  60
   61 KKLIERINQY ESESDLDRQT QLNMLQGLES TIT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	266.9794
Match:	1a6dA_
Description:	Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [1246-1556]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GCNGLYLDHY RSYVHGSGKV DVLIEKFQTR LPKLKDIILT WSYCKKCGTS TPILQISEKT  60
   61 WNHSFGKYLE VMFWSYKDSV TGIGKCPHDF TKDHVKYFGY NDLVVRLEYS DLEVHELITP 120
  121 PRKIKWKPHI DIKLKVELYY KILEKINNFY GSVLSRLERI KLDSMTKDKV LSGQAKIIEL 180
  181 KSNATEEQKL MLQDLDTFYA DSPCDQHLPL NLVIKSLYDK AVNWNSTFAI FAKSYLPSET 240
  241 DISRITAKQL KKLFYDSSRK DSEDKKSLHD EKAKTRKPEK NELPLEGLKD VEKPKIDSKN 300
  301 TTENRDRTNE P

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8

Region A:
Residues: [1557-1906]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNAVTITTFK DDTPIIPTSG TSHLTVTPSA SSVSSSLTPQ TEERPPISRS GTGISMTHDK  60
   61 STRPNIRKMS SDSSLCGLAS LANEYSKNNK VSKLATFFDQ MHFDALSKEF ELERERERLQ 120
  121 LNKDKYQAIR LQTSTPIVEI YKNVKDAVDE PLHSRSSGNN LSSANVKTLE APVGEHSRAN 180
  181 NCNPPNLDQN LETELENSIS QWGENILNPS GKTTASTHLN SKPVVKETSE NPKSIVRESD 240
  241 NSKSEPLPPV ITTTTVNKVE STPQPEKSLL MKTLSNFWAD RSAYLWKPLV YPTCPSEHIF 300
  301 TDSDVIIRED EPSSLIAFCL STSDYRNKMM NLNVQQQQQQ QTAEAAPAKT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9

Region A:
Residues: [1907-2207]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGNSGGTTQT GDPSVNISPS VSTTSHNKGR DSEISSLVTT KEGLLNTPPI EGARDRTPQE  60
   61 SQTHSQANLD TLQELEKIMT KKTATHLRYQ FEEGLTVMSC KIFFTEHFDV FRKICDCQEN 120
  121 FIQSLSRCVK WDSNGGKSGS GFLKTLDDRF IIKELSHAEL EAFIKFAPSY FEYMAQAMFH 180
  181 DLPTTLAKVF GFYQIQVKSS ISSSKSYKMD VIIMENLFYE KKTTRIFDLK GSMRNRHVEQ 240
  241 TGKANEVLLD ENMVEYIYES PIHVREYDKK LLRASVWNDT LFLAKMNVMD YSLVIGIDNE 300
  301 G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	180.325697
Match:	1bo1A_
Description:	Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
Matching Structure (courtesy of the PDB):

Predicted Domain #10

Region A:
Residues: [2208-2278]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTLTVGIIDF IRTFTWDKKL ESWVKEKGLV GGASVIKQPT VVTPRQYKKR FREAMERYIL  60
   61 MVPDPWYWEG N

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.06
Match:	1bo1A
Description:	Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
Matching Structure (courtesy of the PDB):

Predicted Domain #11

Region A:
Residues: [1834-1938]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WADRSAYLWK PLVYPTCPSE HIFTDSDVII REDEPSSLIA FCLSTSDYRN KMMNLNVQQQ  60
   61 QQQQTAEAAP AKTGGNSGGT TQTGDPSVNI SPSVSTTSHN KGRDS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12

Region A:
Residues: [1939-2207]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EISSLVTTKE GLLNTPPIEG ARDRTPQESQ THSQANLDTL QELEKIMTKK TATHLRYQFE  60
   61 EGLTVMSCKI FFTEHFDVFR KICDCQENFI QSLSRCVKWD SNGGKSGSGF LKTLDDRFII 120
  121 KELSHAELEA FIKFAPSYFE YMAQAMFHDL PTTLAKVFGF YQIQVKSSIS SSKSYKMDVI 180
  181 IMENLFYEKK TTRIFDLKGS MRNRHVEQTG KANEVLLDEN MVEYIYESPI HVREYDKKLL 240
  241 RASVWNDTLF LAKMNVMDYS LVIGIDNEG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	87.154902
Match:	1bo1A
Description:	Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
1-phosphatidylinositol-4-phosphate 5-kinase activity	4.78387945404586	bayes_pls_golite062009
inositol or phosphatidylinositol kinase activity	4.31726963575315	bayes_pls_golite062009
lipid kinase activity	3.63026201392483	bayes_pls_golite062009
phosphatidylinositol phosphate kinase activity	3.5005619620026	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.8512866333787	bayes_pls_golite062009
acid-amino acid ligase activity	2.80917598973106	bayes_pls_golite062009
kinase activity	2.68971389233526	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.31077377326314	bayes_pls_golite062009
catalytic activity	1.87792712964225	bayes_pls_golite062009
transferase activity	1.20817067352467	bayes_pls_golite062009
ligase activity	1.05123871944442	bayes_pls_golite062009
binding	0.64375712515604	bayes_pls_golite062009
protein binding	0.444571506795422	bayes_pls_golite062009
protein kinase activity	0.422676745032915	bayes_pls_golite062009
protein serine/threonine kinase activity	0.189737258618863	bayes_pls_golite062009

Predicted Domain #13

Region A:
Residues: [2208-2278]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTLTVGIIDF IRTFTWDKKL ESWVKEKGLV GGASVIKQPT VVTPRQYKKR FREAMERYIL  60
   61 MVPDPWYWEG N

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.05
Match:	2gk9A
Description:	No description for 2gk9A was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: