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Protein Overview: BEM2

General Information:
Name(s) found: BEM2 / YER155C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2167 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    intracellular [TASLink to PubMed article]
    Biological Process: small GTPase mediated signal transduction [IPILink to PubMed article]
    cellular cell wall organization [IPILink to PubMed article]
    microtubule cytoskeleton organization [IGILink to PubMed article]
    budding cell bud growth [IPILink to PubMed article]
    actin cytoskeleton organization [IGILink to PubMed articleLink to PubMed article]
    Molecular Function: Rho GTPase activator activity [IDALink to PubMed article]
    signal transducer activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKGLLWSKNR KSSTASASSS STSTSHKTTT ASTASSSSPS SSSQTIRNST SGASPYMHSH  60
   61 HHHGQGHSHH RGEDNNRDKR KSSVFPPSKQ YTSTSSSQVN LGMYHSDTNT RSSRSIASTL 120
  121 KDDSPSVCSE DEISNSSSQK SNAQDETPIA YKKSAHSKDS LLPSRSSSLS PPQSRCSTGT 180
  181 TLEKSLNTSG ISNSSGTNNN NSNNNNDNEQ KQRNVIHLNS ENYDTTVFKT GWVNKSHGQT 240
  241 VATNYNSSMT APSSSSSSSS QNLRNDAYSR NRESRFYGND GSSLKNDDSS STTATNSGND 300
  301 VASARSSMAI DPQMLVPDYR LYRAQLKGCV LNLYKSGLNS NIKFFDPTLP ASNSSIANEN 360
  361 HQQKKQQTNN QAQAEALHQK QSFGQMGEPI TLDLKYLSEV YPHPDLRQDS DGKIISGTIE 420
  421 SLCHTVLFYP GPKQSDVPNE KSLSKTHRAV INLLLMFPLL DHFIKFLKVF NQFGLSFTKN 480
  481 KSRLTNNSTQ FYNISPAVDD SMTQRLALTA KTILDVFPGF LLDEPMLKTI ISLLDTISLH 540
  541 NDEISNNLKI KIANKHNELM KLTAFTRSLP MATSSTHELE IILDPSHFLS LDITTLADEV 600
  601 HHINLKFDKV WAPKFDYSLL YDSKFINRRI VSLNPLVFNN DQNIHFLGRL LISHLFPTNP 660
  661 EFSKKVTPKV RAELLDKWVQ IGCRFEHLGD MVSWLAVATI ICSIPVLRSS SWKYVPDQSL 720
  721 KTIFKDWVPT IIQLERRQRT SKSTSSVFIL APPNLDDDFT RANVISYFGD LLIHADDLPS 780
  781 DTKFKYLEKK INRTKNAFHK WQQRLQAIDS TRHKTNSTEN VRDNDSPNNV VYQLWKFHLS 840
  841 QPPLNIEGIM KLSVQHEPPI IDQKAYSTIG SQRSALVTGS YLPILFNELF PNYSLFPKNT 900
  901 LVGAASDAKL PPPRSSARLS KSLSISEPIP IASNSHTMGS LTDDAMSSKN DNNKVTGVGK 960
  961 IDGPVIKEMS SKQSNKQRLL KSVRDVFNID MDVFHISDEL VFKSVYDNDG KSRPASMVIE1020
 1021 TPKRFSQHSS MLINNPATPN QKMRDSLDTT GRLSKTLENM DFFNNIGQVS DSLKESIIRV1080
 1081 VLKSSSLEKI FDLLVLTSNI FSKLVDTKDL ENYYYHQRQR GHSTRGLSDD NIGLLDYAFV1140
 1141 KLTMDNDIFT ETFFNTYKSF TTTTTVLENM AKRYVGAKSC SVSISKILDR SDDSKMKINE1200
 1201 DTNLVSSSLY DQNFPVWDMK VTDDENINLI YMAKIQIGAA EAILHLVKNH YSDFTDDLCN1260
 1261 NSTLLDIIKI MEQEVSTEWP TRIANSKLQK SLPENFVIET ENLLTTLTDL FHGIKSAYQK1320
 1321 QLYRPIGVNR TQKRITDILN SFNTFSFTDL NNIIDDPSFS DDMIRSFQKL HSTNYEDILE1380
 1381 WIYQLDNFIS KKFNLVSKKD WIVLFQELEL LSKESLVSFF NYPLHFKSSK LINPGYLQLH1440
 1441 EFEISNLFTW ISTLILKDDN GTESLFFEKL PQSIKLLIKL HTSLTTFFVM EISNVNKSSS1500
 1501 ERLTTCKVIL QILNYIRWKN GSLDLFDSEE DESPHAICPH IPAFIETAIA HAIISPESRN1560
 1561 YELSWIKASE KLSDPTKGTQ NLRSISNVLE KIDDIHIKRF IEIDDVFSKN CKNLCPCPGW1620
 1621 FISRLLEISQ FVPNMSITNS KLINFDKRRF VNNIISNVLD LIPNEREFPL DIEMSDENPS1680
 1681 KRTTFGRILF NNFEDVNKVY RKKTKKVSES EAISERFQEQ GVFNEILVNE IEKIKREARK1740
 1741 LEVLLDQEKI LKNSAALHQA VPKKNRKSVI ISGTHSDNDH SYNINKNTGQ TPSLGSVMES1800
 1801 NNSARNRRDS RASFSTNRSS VVSNSSHNGV SKKIGGFFRR PFSIGGFNTS SSNYSLNSIL1860
 1861 SQEVSSNKSI LPSILPEVDS MQLHDLKPSY SLKTFEIKSI MEIINHRNIP AYYYAFKIVM1920
 1921 QNGHEYLIQT ASSSDLTEWI KMIKASKRFS FHSKKYKGKT HNKIFGVPLE DVCERENTLI1980
 1981 PTIVVKLLEE IELRGLDEVG LYRIPGSIGS INALKNAFDE EGATDNSFTL EDDRWFEVNA2040
 2041 IAGCFKMYLR ELPDSLFSHA MVNDFTDLAI KYKAHAMVNE EYKRMMNELL QKLPTCYYQT2100
 2101 LKRIVFHLNK VHQHVVNNKM DASNLAIVFS MSFINQEDLA NSMGSRLGAV QTILQDFIKN2160
 2161 PNDYFKQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BEM2 PEA2 SPA2
    View Details Gavin AC, et al. (2006) BEM2 KEL1 LTE1
    View Details Gavin AC, et al. (2002) ACC1 ADH1 AMN1 ARP9 ARX1 ASC1 ATG26 AVO1 AVT4 BEM2 BMS1 BRX1 BUD14 BUD20 BUD3 CBF5 CCM1 CCT2 CDC25 CEG1 CET1 CIC1 CLU1 COP1 CTR9 CYR1 CYS4 DBP10 DBP9 DCP2 DIM1 DRS1 EBP2 ECM16 EHD3 EMG1 ENP1 ERB1 FAB1 FPR4 FYV4 GCN1 GEP3 HAS1 HDA1 HER1 HHF1, HHF2 HIS3 HRK1 HRR25 HSC82 IMG1 IMG2 IML1 IMP3 IMP4 INP2 IPI1 IPI3 KIN3 KRE33 KRR1 LHP1 LOC1 LSG1 LSM12 LTV1 MAK21 MAK5 MDN1 MDS3 MHR1 MIA40 MIS1 MPP10 MRH4 MRM1 MRP1 MRP10 MRP13 MRP17 MRP20 MRP21 MRP4 MRP49 MRP51 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 MRPS16 MRPS17 MRPS18 MRPS28 MRPS5 MRPS8 MRPS9 MRT4 NAM9 NAP1 NIP1 NIP7 NMD3 NOB1 NOC2 NOC3 NOC4 NOG1 NOG2 NOP1 NOP12 NOP14 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PAP2 PDB1 PET123 PNO1 PPH3 PRP43 PRT1 PSD2 PSY2 PSY4 PUF6 PUS7 RCL1 REI1 RET2 RGA2 RIO2 RIX1 RIX7 RLP24 RLP7 ROM2 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RSM10 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 RTC6 RTR1 SAM1 SAP155 SAP185 SAP190 SCP160 SDA1 SEC1 SEC26 SEC27 SEC65 SEC7 SIN4 SIT4 SKI2 SKI3 SLX9 SNF12 SNF2 SNF5 SNF6 SNU13 SOF1 SPB1 SPB4 SPT16 SPT5 SRO9 SRP14 SRP21 SRP54 SRP68 SRP72 SSA3 SSA4 SSF1 SSZ1 SWI1 SWI3 SWP82 SWT21 SYP1 TAF5 TDH3 TIF4631 TIF6 TOP2 TRM3 TSR1 TUB3 UBP10 URB1 UTP10 UTP15 UTP20 UTP22 UTP6 UTP7 VPS1 YDR115W YGL036W YGR054W YML6 YTM1 ZUO1
    View Details Ho Y, et al. (2002) AAC3 AHA1 ATP3 BEM2 COP1 DUF1 ECM10 EDE1 FOL2 GCD11 HOM3 HOR2 HTB2 ILV2 LHS1 NIP1 OYE2 PIL1 POR1 PRB1 PTC3 RAD52 RAD59 RHR2 RPG1 SEC27 SEC53 SES1 SRV2 TEF4 TIF34 TIF35 UBA1 UBI4 VMA8 YER138C YPT31

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BEM2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..575] deduced N/A No confident structure predictions are available.
    2 View Details [576..810] Pfam 95.744727 RasGEF domain No confident structure predictions are available.
    3 View Details [811..1104] deduced N/A No confident structure predictions are available.
    4 View Details [1105..1188] Pfam 22.853872 Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif No confident structure predictions are available.
    5 View Details [1189..1614] deduced N/A No confident structure predictions are available.
    6 View Details [1615..1914] MSA 2.146989 View MSA. No confident structure predictions are available.
    7 View Details [1915..2051] PSI-BLAST 124.211549 Graf
    8 View Details [2052..2167] PSI-BLAST 124.211549 Graf
    9 View Details [1873..2167] PSI-BLAST 71.30103 Crystal Structure of the Human Beta2-Chimaerin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9
    Term Confidence Notes
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  3.29568423512865 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • binding
    		•  2.36195429973813 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.8643617990865 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.23177892465869 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.2233434243135 bayes_pls_golite062009
  • DNA binding
    		•  1.13840440643872 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • actin binding
    		•  1.02058870188398 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • tubulin binding
    		•  0.607820429385701 bayes_pls_golite062009
  • transcription factor activity
    		•  0.570759131322384 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.31992783387711 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
  • catalytic activity
    		•  0.194464246602439 bayes_pls_golite062009
  • motor activity
    		•  0.17371606412934 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.0044514849726196 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle