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Protein Overview: CDC25

General Information:
Name(s) found: CDC25 / YLR310C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1589 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: traversing start control point of mitotic cell cycle [IMPLink to PubMed article]
    Ras protein signal transduction [TASLink to PubMed article]
    replicative cell aging [IMPLink to PubMed article]
    Molecular Function: Ras guanyl-nucleotide exchange factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDTNTSIPN TSSAREAGNA SQTPSISSSS NTSTTTNTES SSASLSSSPS TSELTSIRPI  60
   61 GIVVAAYDFN YPIKKDSSSQ LLSVQQGETI YILNKNSSGW WDGLVIDDSN GKVNRGWFPQ 120
  121 NFGRPLRDSH LRKHSHPMKK YSSSKSSRRS SLNSLGNSAY LHVPRNPSKS RRGSSTLSAS 180
  181 LSNAHNAETS SGHNNTVSMN NSPFSAPNDA SHITPQSSNF NSNASLSQDM TKSADGSSEM 240
  241 NTNAIMNNNE TNLQTSGEKA GPPLVAEETI KILPLEEIEM IINGIRSNIA STWSPIPLIT 300
  301 KTSDYKLVYY NKDLDIYCSE LPLISNSIME SDDICDSEPK FPPNDHLVNL YTRDLRKNAN 360
  361 IEDSSTRSKQ SESEQNRSSL LMEKQDSKET DGNNNSINDD DNNNENNKNE FNEAGPSSLN 420
  421 SLSAPDLTQN IQSRVVAPSR SSILAKSDIF YHYSRDIKLW TELQDLTVYY TKTAHKMFLK 480
  481 ENRLNFTKYF DLISDSIVFT QLGCRLMQHE IKAKSCSKEI KKIFKGLISS LSRISINSHL 540
  541 YFDSAFHRKK MDTMNDKDND NQENNCSRTE GDDGKIEVDS VHDLVSVPLS GKRNVSTSTT 600
  601 DTLTPMRSSF STVNENDMEN FSVLGPRNSV NSVVTPRTSI QNSTLEDFSP SNKNFKSAKS 660
  661 IYEMVDVEFS KFLRHVQLLY FVLQSSVFSD DNTLPQLLPR FFKGSFSGGS WTNPFSTFIT 720
  721 DEFGNATKNK AVTSNEVTAS SSKNSSISRI PPKMADAIAS ASGYSANSET NSQIDLKASS 780
  781 AASGSVFTPF NRPSHNRTFS RARVSKRKKK YPLTVDTLNT MKKKSSQIFE KLNNATGEHL 840
  841 KIISKPKSRI RNLEINSSTY EQINQNVLLL EILENLDLSI FINLKNLIKT PSILLDLESE 900
  901 EFLVHAMSSV SSVLTEFFDI KQAFHDIVIR LIMTTQQTTL DDPYLFSSMR SNFPVGHHEP 960
  961 FKNISNTPLV KGPFHKKNEQ LALSLFHVLV SQDVEFNNLE FLNNSDDFKD ACEKYVEISN1020
 1021 LACIIVDQLI EERENLLNYA ARMMKNNLTA ELLKGEQEKW FDIYSEDYSD DDSENDEAII1080
 1081 DDELGSEDYI ERKAANIEKN LPWFLTSDYE TSLVYDSRGK IRGGTKEALI EHLTSHELVD1140
 1141 AAFNVTMLIT FRSILTTREF FYALIYRYNL YPPEGLSYDD YNIWIEKKSN PIKCRVVNIM1200
 1201 RTFLTQYWTR NYYEPGIPLI LNFAKMVVSE KIPGAEDLLQ KINEKLINEN EKEPVDPKQQ1260
 1261 DSVSAVVQTT KRDNKSPIHM SSSSLPSSAS SAFFRLKKLK LLDIDPYTYA TQLTVLEHDL1320
 1321 YLRITMFECL DRAWGTKYCN MGGSPNITKF IANANTLTNF VSHTIVKQAD VKTRSKLTQY1380
 1381 FVTVAQHCKE LNNFSSMTAI VSALYSSPIY RLKKTWDLVS TESKDLLKNL NNLMDSKRNF1440
 1441 VKYRELLRSV TDVACVPFFG VYLSDLTFTF VGNPDFLHNS TNIINFSKRT KIANIVEEII1500
 1501 SFKRFHYKLK RLDDIQTVIE ASLENVPHIE KQYQLSLQVE PRSGNTKGST HASSASGTKT1560
 1561 AKFLSEFTDD KNGNFLKLGK KKPPSRLFR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC25 MDS3 SAP185 YBR225W
    View Details Krogan NJ, et al. (2006) CDC25 MDS3 YBR225W
    View Details Gavin AC, et al. (2006) CDC25 HRK1 MDS3 SAP185 SIT4
    View Details Gavin AC, et al. (2002) ACC1 AVT4 BEM2 CCT2 CDC25 FAB1 HRK1 MDS3 MIA40 MRPL3 SAP155 SAP185 SAP190 SIT4 SWT21 YBR225W
    View Details Ho Y, et al. (2002) CDC25 CKA2 CKI1 DCP2 EDC3 EDE1 ENP1 FPR3 GCR2 GIN4 GLC7 HOM3 HRR25 IRA1 IRA2 MDS3 MYO2 MYO4 NAP1 PMD1 PRS2 PRS3 PRS5 RIM11 RPM2 SEC23 SFB3 SGM1 SIT4 TGL1 TPS1 TSL1 TSR1 YDR170W-A YER138C YER160C YJR027W YJR028W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run NSE5 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CDC25 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] PSI-BLAST 47.69897 c-src protein tyrosine kinase; c-src tyrosine kinase
    2 View Details [130..256] PSI-BLAST 47.69897 c-src protein tyrosine kinase; c-src tyrosine kinase
    3 View Details [257..975] deduced N/A No confident structure predictions are available.
    4 View Details [976..1079] PSI-BLAST 3.221849 Son of sevenless-1 (sos-1)
    5 View Details [1080..1263]
    [1467..1494]    		 PSI-BLAST 488.0 Son of sevenless protein homolog 1 (sos-1)
    6 View Details [1264..1466]
    [1495..1589]    		 PSI-BLAST 488.0 Son of sevenless protein homolog 1 (sos-1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • signal transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • protein binding
    		•  2.14586566310919 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • receptor binding
    		•  1.02111138016453 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.69502098407037 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.540818657754841 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.456661966897198 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.352421112301971 bayes_pls_golite062009
  • DNA binding
    		•  0.281643350069021 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0898978787421796 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.66986263418539 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.64990514605397 bayes_pls_golite062009
  • signal transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.2550809703725 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.25381967078645 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.90578029954417 bayes_pls_golite062009
  • small GTPase binding
    		•  0.8507658747425 bayes_pls_golite062009
  • GTPase binding
    		•  0.82889812790119 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.745321902095093 bayes_pls_golite062009
  • receptor binding
    		•  0.50127063593663 bayes_pls_golite062009
  • receptor activity
    		•  0.353510125274044 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.324566338715835 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.207829786337892 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  0.13700176999256 bayes_pls_golite062009
  • DNA binding
    		•  0.136435190086451 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.118897432176337 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.10105990547756 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle