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Protein Overview: HOM3

General Information:
Name(s) found: HOM3 / YER052C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 527 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    methionine metabolic process [TASLink to PubMed article]
    threonine metabolic process [TASLink to PubMed article]
    homoserine biosynthetic process [TAS]
    Molecular Function: aspartate kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPMDFQPTSS HSNWVVQKFG GTSVGKFPVQ IVDDIVKHYS KPDGPNNNVA VVCSARSSYT  60
   61 KAEGTTSRLL KCCDLASQES EFQDIIEVIR QDHIDNADRF ILNPALQAKL VDDTNKELEL 120
  121 VKKYLNASKV LGEVSSRTVD LVMSCGEKLS CLFMTALCND RGCKAKYVDL SHIVPSDFSA 180
  181 SALDNSFYTF LVQALKEKLA PFVSAKERIV PVFTGFFGLV PTGLLNGVGR GYTDLCAALI 240
  241 AVAVNADELQ VWKEVDGIFT ADPRKVPEAR LLDSVTPEEA SELTYYGSEV IHPFTMEQVI 300
  301 RAKIPIRIKN VQNPLGNGTI IYPDNVAKKG ESTPPHPPEN LSSSFYEKRK RGATAITTKN 360
  361 DIFVINIHSN KKTLSHGFLA QIFTILDKYK LVVDLISTSE VHVSMALPIP DADSLKSLRQ 420
  421 AEEKLRILGS VDITKKLSIV SLVGKHMKQY IGIAGTMFTT LAEEGINIEM ISQGANEINI 480
  481 SCVINESDSI KALQCIHAKL LSERTNTSNQ FEHAIDERLE QLKRLGI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FPR1 HOM3
    View Details Ho Y, et al. (2002) AAC3 ADE3 AHA1 ALA1 ATP3 BEM2 CDC25 CKI1 ECM10 FPR1 GCD11 GCR2 GDI1 GIN4 GSP1 GSP2 HOM3 HOR2 HSH49 ILV2 IRA1 IRA2 MLP2 MOG1 MYO2 MYO4 NAP1 NTG1 OPY1 OYE2 PFK2 PGM1 PGM2 PIL1 PMD1 PRB1 PRS2 PRS3 PRS5 PTC3 RAD52 RAD59 RHR2 RIM11 RNA1 RPB3 RPT3 SEC27 SEC53 SRM1 SSZ1 TEF4 THS1 TPS1 TSL1 UBA1 URA1 VMA8 YDR170W-A YDR341C YER138C YER160C YJR027W YJR028W YPT31

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HOM3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..339] PSI-BLAST 18.39794 N-acetyl-l-glutamate kinase
    2 View Details [340..527] MSA 7.152983 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetolactate synthase activity
    		•  3.48670706716817 bayes_pls_golite062009
  • aspartate kinase activity
    		•  3.23731032633773 bayes_pls_golite062009
  • transferase activity
    		•  3.047646907595 bayes_pls_golite062009
  • catalytic activity
    		•  2.83338756483354 bayes_pls_golite062009
  • kinase activity
    		•  2.6815187488202 bayes_pls_golite062009
  • phosphotransferase activity, carboxyl group as acceptor
    		•  2.65970393362911 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.63366715780289 bayes_pls_golite062009
  • amino acid kinase activity
    		•  2.38310367076654 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  2.27460110663386 bayes_pls_golite062009
  • acetylglutamate kinase activity
    		•  1.28891782911186 bayes_pls_golite062009
  • glutamate 5-kinase activity
    		•  0.416864856459166 bayes_pls_golite062009
  • binding
    		•  0.416787048641206 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle