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Protein Overview: NTG1

General Information:
Name(s) found: NTG1 / YAL015C [SGD]
Description(s) found:
Found 26 descriptions.
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  • DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 399 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: DNA repair [IDALink to PubMed article]
    base-excision repair [IDALink to PubMed article]
    base-excision repair, AP site formation [IDALink to PubMed article]
    Molecular Function: oxidized pyrimidine base lesion DNA N-glycosylase activity [IDALink to PubMed article][ISSLink to PubMed article]
    DNA-(apurinic or apyrimidinic site) lyase activity [IDALink to PubMed article]
    oxidized purine base lesion DNA N-glycosylase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKISKYSSM AILRKRPLVK TETGPESELL PEKRTKIKQE EVVPQPVDID WVKSLPNKQY  60
   61 FEWIVVRNGN VPNRWATPLD PSILVTPAST KVPYKFQETY ARMRVLRSKI LAPVDIIGGS 120
  121 SIPVTVASKC GISKEQISPR DYRLQVLLGV MLSSQTKDEV TAMAMLNIMR YCIDELHSEE 180
  181 GMTLEAVLQI NETKLDELIH SVGFHTRKAK YILSTCKILQ DQFSSDVPAT INELLGLPGV 240
  241 GPKMAYLTLQ KAWGKIEGIC VDVHVDRLTK LWKWVDAQKC KTPDQTRTQL QNWLPKGLWT 300
  301 EINGLLVGFG QIITKSRNLG DMLQFLPPDD PRSSLDWDLQ SQLYKEIQQN IMSYPKWVKY 360
  361 LEGKRELNVE AEINVKHEEK TVEETMVKLE NDISVKVED

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AHA1 ARP2 CLU1 ECM10 FET3 HOM3 IDH1 NTG1 OPY1 PGM1 PGM2 PRB1 RAD59 RFC2 RPB3 RPC40 RPT3 SEC27 TIF34

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NTG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..119] deduced N/A No confident structure predictions are available.
    2 View Details [120..132]
    [245..399]    		 PSI-BLAST 128.751666 Endonuclease III
    3 View Details [133..244] PSI-BLAST 128.751666 Endonuclease III

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA N-glycosylase activity
    		•  4.8124964619976 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing N-glycosyl compounds
    		•  4.26870112679392 bayes_pls_golite062009
  • DNA-(apurinic or apyrimidinic site) lyase activity
    		•  3.71152530486175 bayes_pls_golite062009
  • oxidized base lesion DNA N-glycosylase activity
    		•  2.49872706126491 bayes_pls_golite062009
  • hydrolase activity
    		•  2.39042189031819 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.24777884454113 bayes_pls_golite062009
  • 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
    		•  2.21048599823382 bayes_pls_golite062009
  • catalytic activity
    		•  2.13345932727422 bayes_pls_golite062009
  • alkylbase DNA N-glycosylase activity
    		•  1.5832578018127 bayes_pls_golite062009
  • DNA binding
    		•  1.44394874535958 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.36800347239439 bayes_pls_golite062009
  • oxidized purine base lesion DNA N-glycosylase activity
    		•  1.32985950765371 bayes_pls_golite062009
  • damaged DNA binding
    		•  1.32391480975295 bayes_pls_golite062009
  • binding
    		•  1.15752946565805 bayes_pls_golite062009
  • DNA-3-methyladenine glycosylase I activity
    		•  1.06383943982125 bayes_pls_golite062009
  • oxidized pyrimidine base lesion DNA N-glycosylase activity
    		•  0.889914753262716 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  0.879508131574476 bayes_pls_golite062009
  • purine-specific mismatch base pair DNA N-glycosylase activity
    		•  0.68578837518217 bayes_pls_golite062009
  • mismatch base pair DNA N-glycosylase activity
    		•  0.661651574677137 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.493252955870142 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.32094102946624 bayes_pls_golite062009
  • protein binding
    		•  0.0921713980805489 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.0676784802238829 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0420287478494503 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle