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Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated 3-methylpurines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes the alkylated base 7-methylguanine. Catalysis of the hydrolysis of any N-glycosyl bond.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: alkylbase DNA N-glycosylase activity
Acc: GO:0003905
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.
Synonyms:
  • 3-methyladenine DNA glycosylase II
  • deoxyribonucleate 3-methyladenine glycosidase II
  • alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
  • DNA glycosidase II activity
  • DNA-3-methyladenine glycosidase II activity
  • DNA-3-methyladenine glycosylase II
  • alkylbase DNA glycosidase activity
  • GO:0004036
  • AlkA
Proteins in PDR annotated with:
   This term: 10 [Search]
   Term or descendants: 24 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003905 - alkylbase DNA N-glycosylase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle