YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: IDH1

General Information:
Name(s) found: IDH1 / YNL037C [SGD]
Description(s) found:
Found 29 descriptions.
SHOW ALL
  • Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 360 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    mitochondrial nucleoid [IDALink to PubMed article]
    Biological Process: glutamate biosynthetic process [TASLink to PubMed article]
    isocitrate metabolic process [TASLink to PubMed article]
    tricarboxylic acid cycle [TASLink to PubMed article]
    Molecular Function: isocitrate dehydrogenase (NAD+) activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNRTIAKRT LATAAQAERT LPKKYGGRFT VTLIPGDGVG KEITDSVRTI FEAENIPIDW  60
   61 ETINIKQTDH KEGVYEAVES LKRNKIGLKG LWHTPADQTG HGSLNVALRK QLDIYANVAL 120
  121 FKSLKGVKTR IPDIDLIVIR ENTEGEFSGL EHESVPGVVE SLKVMTRPKT ERIARFAFDF 180
  181 AKKYNRKSVT AVHKANIMKL GDGLFRNIIT EIGQKEYPDI DVSSIIVDNA SMQAVAKPHQ 240
  241 FDVLVTPSMY GTILGNIGAA LIGGPGLVAG ANFGRDYAVF EPGSRHVGLD IKGQNVANPT 300
  301 AMILSSTLML NHLGLNEYAT RISKAVHETI AEGKHTTRDI GGSSSTTDFT NEIINKLSTM 360
  361

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) IDH1 IDH2
    View Details Krogan NJ, et al. (2006) IDH1 IDH2 YHR182W
    View Details Ho Y, et al. (2002) ACC1 ADH2 ADR1 AHA1 ARP2 ATP3 AVO1 BCK1 BTN2 BUL1 CCT2 CCT3 CCT5 CCT6 CDC53 CLU1 CMD1 CMP2 COP1 CPA2 CPR6 CTR1 DED1 DEF1 DHH1 DPB2 EAP1 EGD2 FAR8 FET3 FOL2 FUN12 GAL7 GDT1 GND1 GPA2 GPH1 GUF1 GYP5 HRT1 HRT3 IDH1 ILV2 ILV5 IPP1 KIC1 KIN2 LHS1 LSC1 LST8 LYS12 MEH1 MET16 MET18 MKK2 MKT1 NMD5 NOG2 NPA3 NTG1 OYE2 PDC6 PDX1 PET10 PHO84 PHO85 PHO86 PIL1 PMA1 POR1 PPH21 PPH22 PRB1 PRE10 PUF3 QCR2 RCN2 REP1 RFC2 RFC3 RGD1 RIX7 RNQ1 RPC40 RPN1 RPN12 RPN6 RPN7 RPN8 RPT3 RRP3 RTT101 RVB1 RVS167 SDH2 SEC27 SEC28 SIP1 SIS1 SKG3 SKP1 SLC1 SLT2 SLX1 SMK1 SPS1 SRP54 STI1 TCP1 TEF4 TEM1 TFC7 TIF1, TIF2 TIF34 UBI4 URA7 VMA8 VPS74 YBT1 YCR076C YER077C YGR266W YHR033W YKR051W YKU80 YLR243W YLR271W YML020W YPR003C
    View Details Qiu et al. (2008) IDH1 IDP1 KGD1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data IDH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..360] PSI-BLAST 511.218487 3-isopropylmalate dehydrogenase, IPMDH


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.58

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle