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Protein Overview: URA7

General Information:
Name(s) found: URA7 / YBL039C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 579 amino acids

    Gene Ontology:
    Cellular Component: cytosol [TASLink to PubMed article]
    Biological Process: CTP biosynthetic process [IDALink to PubMed article][TASLink to PubMed article]
    phospholipid biosynthetic process [IMPLink to PubMed article]
    pyrimidine base biosynthetic process [IMPLink to PubMed article]
    Molecular Function: CTP synthase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKYVVVSGGV ISGIGKGVLA SSTGMLMKTL GLKVTSIKID PYMNIDAGTM SPLEHGECFV  60
   61 LDDGGETDLD LGNYERYLGV TLTKDHNITT GKIYSHVIAK ERKGDYLGKT VQIVPHLTNA 120
  121 IQDWIERVAK IPVDDTGMEP DVCIIELGGT VGDIESAPFV EALRQFQFKV GKENFALIHV 180
  181 SLVPVIHGEQ KTKPTQAAIK GLRSLGLVPD MIACRCSETL DKPTIDKIAM FCHVGPEQVV 240
  241 NVHDVNSTYH VPLLLLEQKM IDYLHARLKL DEISLTEEEK QRGLELLSKW KATTGNFDES 300
  301 METVKIALVG KYTNLKDSYL SVIKALEHSS MKCRRKLDIK WVEATDLEPE AQESNKTKFH 360
  361 EAWNMVSTAD GILIPGGFGV RGTEGMVLAA RWARENHIPF LGVCLGLQIA TIEFTRSVLG 420
  421 RKDSHSAEFY PDIDEKNHVV VFMPEIDKET MGGSMRLGLR PTFFQNETEW SQIKKLYGDV 480
  481 SEVHERHRHR YEINPKMVDE LENNGLIFVG KDDTGKRCEI LELKNHPYYI ATQYHPEYTS 540
  541 KVLDPSKPFL GLVAASAGIL QDVIEGKYDL EAGENKFNF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ASN2 STT3 URA7
    View Details Gavin AC, et al. (2006) CLU1 PRS3 RPL35A, RPL35B RPS6A, RPS6B URA7
    View Details Gavin AC, et al. (2002) ACC1 CCT8 CLU1 CPA2 FDH1 GCN20 GFA1 GUS1 ILV1 KAP123 LYS12 MRPL3 PSA1 RPA135 RPB2 RPN10 RPN11 RPN12 RPN8 RPT3 RPT5 RPT6 SAM1 SEC27 SMC3 TCB1 TIF1, TIF2 TSA1 TUB3 URA7 VAS1 YOL098C
    View Details Ho Y, et al. (2002) AAC3 ARO1 ARP2 BUD32 CAR2 COP1 CPA1 CPR6 CRM1 DED1 DIA4 GFA1 GRX3 GRX4 GSY1 GYP5 HEF3 IDH1 IDP2 ILV5 IMD2 IMD4 KAE1 LYS12 MET18 NPA3 NUG1 PHO81 PHO84 PRB1 PRE10 PRP28 RFC4 RNH202 RNQ1 RPN1 RPN5 RPN6 RPT1 RVS167 SEC18 SEC23 SGO1 SMC3 SWM1 TCB3 TMA29 UBR1 URA7 YGL081W YHR033W YLR243W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TIM50 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data URA7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..208] ORFEUS 7.57 Nitrogenase iron protein
    2 View Details [209..579] PSI-BLAST 49.69897 Carbamoyl phosphate synthetase, small subunit N-terminal domain; Carbamoyl phosphate synthetase, small subunit C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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