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Protein Overview: GRX3

General Information:
Name(s) found: GRX3 / YDR098C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 285 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IGILink to PubMed article][IPILink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IGILink to PubMed article][IPILink to PubMed article]
    response to oxidative stress [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: thiol-disulfide exchange intermediate activity [IGILink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCSFQVPSAF SFNYTSYCYK RHQARYYTAA KLFQEMPVIE INDQEQFTYL TTTAAGDKLI  60
   61 VLYFHTSWAE PCKALKQVFE AISNEPSNSN VSFLSIDADE NSEISELFEI SAVPYFIIIH 120
  121 KGTILKELSG ADPKEYVSLL EDCKNSVNSG SSQTHTMENA NVNEGSHNDE DDDDEEEEEE 180
  181 TEEQINARLT KLVNAAPVML FMKGSPSEPK CGFSRQLVGI LREHQVRFGF FDILRDESVR 240
  241 QNLKKFSEWP TFPQLYINGE FQGGLDIIKE SLEEDPDFLQ HALQS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GRX3 GRX4
    View Details Krogan NJ, et al. (2006) FRA2 GRX3
    View Details Ho Y, et al. (2002) AAC3 BUD32 CAR2 CPR6 CRM1 DIA4 FRA1 FRA2 GRX3 GRX4 HEF3 IDP2 IMD2 IMD4 KAE1 NPA3 PHO81 RNH202 RPN1 RPN5 RPN6 RPT1 SEC18 SEC23 SGO1 TMA29 URA7 YHR033W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GRX3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] PSI-BLAST 118.228787 Thioredoxin
    2 View Details [148..285] PSI-BLAST 7.09691 Protein disulfide isomerase, PDI


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle