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Protein Overview: CAR2

General Information:
Name(s) found: CAR2 / YLR438W [SGD]
Description(s) found:
Found 25 descriptions.
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  • L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 424 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: arginine catabolic process [TASLink to PubMed article]
    Molecular Function: ornithine-oxo-acid transaminase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEATLSSKQ TIEWENKYSA HNYHPLPVVF HKAKGAHVWD PEGKLYLDFL SAYSAVNQGH  60
   61 CHPHIIKALT EQAQTLTLSS RAFHNDVYAQ FAKFVTEFFG FETVLPMNTG AEAVETALKL 120
  121 ARRWGYMKKN IPQDKAIILG AEGNFHGRTF GAISLSTDYE DSKLHFGPFV PNVASGHSVH 180
  181 KIRYGHAEDF VPILESPEGK NVAAIILEPI QGEAGIVVPP ADYFPKVSAL CRKHNVLLIV 240
  241 DEIQTGIGRT GELLCYDHYK AEAKPDIVLL GKALSGGVLP VSCVLSSHDI MSCFTPGSHG 300
  301 STFGGNPLAS RVAIAALEVI RDEKLCQRAA QLGSSFIAQL KALQAKSNGI ISEVRGMGLL 360
  361 TAIVIDPSKA NGKTAWDLCL LMKDHGLLAK PTHDHIIRLA PPLVISEEDL QTGVETIAKC 420
  421 IDLL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAR2 OYE2
    View Details Ho Y, et al. (2002) AAC1 AAC3 AAT2 ABP1 ACH1 ACO1 ACS2 ADE5,7 ADH2 ADH4 AFR1 AHA1 AHP1 AIM41 ALA1 ARC1 ARF1 ARG4 ARO1 ARO4 ARP2 ATG11 ATG12 ATG17 ATP3 ATP4 BCY1 BUD13 BUD14 BUD32 CAR2 CDC15 CDC33 CDC60 CLU1 COF1 COR1 CPA2 CPR1 CPR6 CRM1 CRZ1 CYR1 CYS4 DBP8 DCP1 DCP2 DED81 DIA4 DLD3 DMA2 DNM1 DUG1 DUN1 EDC3 EDE1 EGD1 EGD2 EMG1 ENP1 ERG10 ERG13 ERG20 ERG6 ESS1 FAR1 FET4 FOL2 FPR1 FRS2 FUM1 GAS1 GCD11 GCN3 GFA1 GND1 GND2 GPD1 GPD2 GPH1 GRS1 GRX1 GRX3 GRX4 GTO1 GUS1 HEF3 HHF1, HHF2 HRR25 HSP104 HXT6 HXT7 HYP2 IDP2 ILS1 ILV3 ILV5 IMD2 IMD4 IPP1 IST3 KAE1 KGD1 KNS1 LAA1 LOC1 LRO1 LSP1 LTV1 LYS1 MDH1 MDM30 MDN1 MDS3 MET6 MGE1 MPC54 NAP1 NAS6 NPA3 NSA1 NTF2 NUG1 OLA1 OYE2 OYE3 PDC5 PDC6 PEX19 PFK1 PGM2 PHO81 PIL1 PIN4 POR1 PPX1 PRB1 PRM2 PST2 PTC4 PTC7 PUF3 PUP2 PYC2 RAD1 REP1 REX2 RHO1 RIO2 RNH202 RNR1 RNR2 RPB3 RPC19 RPM2 RPN1 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPO21 RPT1 RPT3 RSN1 SAH1 SAP185 SAP190 SAS10 SAW1 SCP160 SEC18 SEC2 SEC23 SEC26 SEC53 SEC6 SEN1 SEN15 SES1 SFB3 SGM1 SGO1 SIT4 SNO2 SNU13 SOD1 SPT5 SSN8 SSZ1 STE20 SUI1 TCB1 TEF4 TFG1 TFP1 THI22 THO2 THR4 THS1 TIF1, TIF2 TMA19 TMA29 TOM1 TPK2 TPK3 TPS1 TRR1 TSA2 TSR1 TYR1 UBA1 UBI4 URA7 UTP22 VMA4 VMA5 VPS21 WTM1 YBL108W YBR028C YBR225W YCK1 YCK2 YCK3 YDL086W YDL124W YDR341C YER138C YGR111W YHR020W YHR033W YHR112C YNK1 YNL208W YPL150W YPT53

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CAR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..424] PSI-BLAST 1289.0 Ornithine aminotransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 4-aminobutyrate transaminase activity
    		•  3.63797881096751 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  3.359406422625 bayes_pls_golite062009
  • transferase activity
    		•  2.59075614411581 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  1.85905571238884 bayes_pls_golite062009
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
    		•  1.74778109525713 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.63055151623667 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.63055151623667 bayes_pls_golite062009
  • N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
    		•  1.4383564662931 bayes_pls_golite062009
  • glutamate decarboxylase activity
    		•  1.34215658716536 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.19150094103499 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.977210827616757 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.892872530648552 bayes_pls_golite062009
  • ligase activity
    		•  0.827063849687833 bayes_pls_golite062009
  • DNA binding
    		•  0.803965264969424 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase binding
    		•  0.78144409237642 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • intramolecular transferase activity, transferring amino groups
    		•  0.659071155545801 bayes_pls_golite062009
  • transcription factor activity
    		•  0.597417107954964 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  0.52897097514616 bayes_pls_golite062009
  • binding
    		•  0.49769115245722 bayes_pls_golite062009
  • ornithine-oxo-acid transaminase activity
    		•  0.311107335626334 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.2609065149092 bayes_pls_golite062009
  • kynureninase activity
    		•  0.242752584041108 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.15938456446406 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.103986924428507 bayes_pls_golite062009
  • sulfurtransferase activity
    		•  0.0450490929307473 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.0254276656964899 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle