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Protein Overview: MDS3

General Information:
Name(s) found: MDS3 / YGL197W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1487 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: negative regulation of sporulation resulting in formation of a cellular spore [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLLQPSTCF CYPLKLPPLP LTSDSNEFDE CARKRLTLDY RTGSAVTLTR SNIFVHGGLT  60
   61 IPLNLPVVNS MQLQKELILF FAKEKNNGSS FRNLNEWISK ETFFLDLMSR TWYRVKTSFD 120
  121 QRTEELLKAE SSSAKADNDT NEIRTDIKKG KSLESPLKER LFHSLCYLDG CLYIFGGLTV 180
  181 SPQSGYELIA TNELWKLDLN TKKWSLLSDD PQIARRFNHT MHVKNENNDN RDTKLIIVGG 240
  241 LNNMDQPVKK IDIYNISQNC WHPKTIPKQP MEITTNVNGI PLALSKDQNF SILVENNEAN 300
  301 VPALAFYMRS DQIDEYLGKD SSKIKENSPI VALPLLSESQ GIRMPSNPAL PKKLLNVPYE 360
  361 LLAPTGDYFG FNIIIGGFHP NYQSSNFHCF IYDINSGKWS RVRTACPDCD INKHRFWRVF 420
  421 VWKSHHQTIL LGTKTDDYYS PSVQRFDHLS TFGLPLVNIF NKTIQLPHHK ISASSLPIPI 480
  481 ENFAKHKDTP LKKVSFTSSA TSQFENYIRY IAPPLEMSSI QSVFPPYAMV LGKDALEIYG 540
  541 KPLSDFEFIT SEGDSIGIPC YLLRKRWGRY FDMLLSQSYT KVCADYETTD TQSTLIKFSP 600
  601 HSSRNSSKAV RQEGRLSSSG SLDNYFEKNF PIFARTSVSE AQNTQPQVAN ADAKAPNTPS 660
  661 TSDEPSSSSS SDLYSTPHYQ RNNDEEDDED PVSPKPVSKS NSIYRPIRKT ESSSTTSSSN 720
  721 GMIFRVPFKE KAAVTSNTEA LLESNLSLQE LSRRRSSLMS IPSGELLRSS ISEAEHQRRA 780
  781 SHPLTSSPLF EDSGTPCGKQ LQQLQQHTIQ NPHNHLSPRR FSRSARSSIS YVSSSSDRRG 840
  841 NSISSRSTSD SFGTPPVLGV LNVPLPPQTR EPNEPPPPCP AMSTGSNTRR SNTLTDYMHS 900
  901 NKASPFSSRR SSHIGRRSST PETENAFSAT PRASLDGQML GKSLKEGSTS QYTQPRMNSF 960
  961 PKANETIQTP TSSNNEWSRQ SVTSNTDSFD SLQSNFALEL EPLLTPRSLY MPWPTSTVRA1020
 1021 FAEFFYTGQV NSKWLLAPVA LDLLVMAKIY EIPLLYKLIL EVLYSILAKK EESLSLICTS1080
 1081 LMETFRTKTL NSYKGDEEKT NTYLTSNDNY QELLKLKVSL ENIDNGYYDP DLLRKQSRAQ1140
 1141 SSSTQESSGS ANGEKTATGA GSLETSSTNV PTVFAGGPRD SHNSVGSIGF PNSMNIQGSR1200
 1201 RSTSGFSPRV KMKSSLSKEI DPKTFYEEYE PKEGKSFDDN DDQQTNIGSF NLHLFDMNYG1260
 1261 SISSSSTNSI SSSDLEEKEE QEQLQDLLEI EREDSAEILD ARFRNKEDDK VTKDISNDKK1320
 1321 RNYLPHEKNN LKAKEGKETR DVREEEEEFD FGLGMLSLNK IKREAKHVDK VDDSVDPLFK1380
 1381 SSAFPQSPIR AYGSTTRTSS ASGKPFRDNR SFNAFSVLTL ENMASANALP PVDYVIKSIY1440
 1441 RTTVLVNDIR LMVRCMDCIE LSKNLRALKK KTMEDISKLK GISKPSP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC25 MDS3 SAP185 YBR225W
    View Details Krogan NJ, et al. (2006) CDC25 MDS3 YBR225W
    View Details Gavin AC, et al. (2006) CDC25 HRK1 MDS3 SAP185 SIT4
    View Details Gavin AC, et al. (2002) ACC1 AVT4 BEM2 BLM10 CCT2 CDC25 DAM1 DBP9 ECM29 EST3 FAB1 GFA1 HRK1 INO4 KAP95 LYS12 MDS3 MIA40 MRPL3 NUD1 PDA1 PDB1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE8 PRE9 PSE1 PUP3 RGR1 RPT3 RPT5 RRP12 SAP155 SAP185 SAP190 SCL1 SIT4 SLX9 SPA2 SRP1 SWT21 ULP1 YBR225W YFL006W YMR310C YRA1
    View Details Ho Y, et al. (2002) ABP1 ACO1 AIM41 ATP4 BUD14 CAR2 CDC25 CKA2 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 EDC3 EDE1 EGD2 ENP1 FPR3 GAS1 GCN3 GLC7 GPH1 HHF1, HHF2 HRR25 HSP104 HXT7 HYP2 IPP1 LOC1 LSP1 LTV1 MDH1 MDS3 MGE1 NSA1 NUG1 OYE2 PEX19 PIL1 PIN4 PTC4 PUF3 RIO2 RPC19 RPM2 SAP185 SAP190 SAS10 SEC2 SEC23 SES1 SFB3 SGM1 SIT4 TGL1 TMA19 TSR1 VMA4 YBR225W YER138C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 MDS3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MDS3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] deduced N/A No confident structure predictions are available.
    2 View Details [89..334] PSI-BLAST 4.522879 Galactose oxidase, C-terminal domain; Galactose oxidase, N-terminal domain; Galactose oxidase, central domain
    3 View Details [335..553] deduced N/A No confident structure predictions are available.
    4 View Details [554..793] MSA 1.003934 View MSA. No confident structure predictions are available.
    5 View Details [794..1487] deduced N/A No confident structure predictions are available.
    6 View Details [794..884] deduced N/A No confident structure predictions are available.
    7 View Details [885..959] deduced N/A No confident structure predictions are available.
    8 View Details [960..1194] deduced N/A No confident structure predictions are available.
    9 View Details [1195..1326] deduced N/A No confident structure predictions are available.
    10 View Details [1327..1487] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle