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Protein Overview: INO4

General Information:
Name(s) found: INO4 / YOL108C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 151 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    Biological Process: phospholipid biosynthetic process [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    specific RNA polymerase II transcription factor activity [IMPLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNDIKEIQT IQPGLSEIKE IKGELANVKK RKRRSKKINK LTDGQIRINH VSSEKKRREL  60
   61 ERAIFDELVA VVPDLQPQES RSELIIYLKS LSYLSWLYER NEKLRKQIIA KHEAKTGSSS 120
  121 SSDPVQEQNG NIRDLVPKEL IWELGDGQSG Q

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) INO2 INO4
    View Details Gavin AC, et al. (2002) BLM10 DAM1 DBP9 ECM29 EST3 GFA1 INO4 KAP95 LYS12 MDS3 NUD1 PDA1 PDB1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE8 PRE9 PSE1 PUP3 RGR1 RPT3 RPT5 RRP12 SCL1 SLX9 SPA2 SRP1 ULP1 YFL006W YMR310C YRA1
    View Details Ho Y, et al. (2002) HHF1, HHF2 HTB1 HTB2 INO4 MAM33 NIP7 PSE1 UTP4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data INO4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] ORFEUS 10.92 Max protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.08855036296174 bayes_pls_golite062009
  • DNA binding
    		•  4.87243318281876 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.77537175825177 bayes_pls_golite062009
  • transcription factor activity
    		•  4.43134840465732 bayes_pls_golite062009
  • binding
    		•  3.63719401349018 bayes_pls_golite062009
  • transcription activator activity
    		•  3.62180682771335 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.17029130860224 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.11931609869373 bayes_pls_golite062009
  • protein binding
    		•  2.53793947976093 bayes_pls_golite062009
  • transcription factor binding
    		•  2.33137487648005 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.01283700957804 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.30186253699056 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.828519845330998 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.560586077390024 bayes_pls_golite062009
  • promoter binding
    		•  0.531949034115114 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.328788240668351 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.172100901723138 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.0815596840205237 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle