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Protein Overview: ECM29

General Information:
Name(s) found: ECM29 / YHL030W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1868 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    proteasome complex [IDALink to PubMed article]
    Biological Process: protein catabolic process [ICLink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSISSDEAKE KQLVEKAELR LAIADSPQKF ETNLQTFLPP LLLKLASPHA SVRTAVFSAL  60
   61 KNLISRINTL PQVQLPVRAL IVQAKEPNLA AQQDSTNVRL YSLLLASKGI DRLSLQDRQQ 120
  121 LLPLVVSNIS CLTGTVAARM FHILLKLILE WVAPQESSHE QEEFVQFLQL DNDGFSFLMR 180
  181 QFTRFFLLVP SKQVQVSQQP LSRGYTCPGL SLTDVAFFTY DAGVTFNKEQ LNKFKKAIFQ 240
  241 FVCRGMAATQ TIEQSPRMIE LMEFLCVVST DSTNLSDDAA QFMKRFPMPY ENEEFITFLQ 300
  301 TLYIGNTANG RPPVKAILQE KILSILNRSH FATTKAECIS LICSIGLHSS EYKLRSLTLS 360
  361 FIRHVAKLNY KNLNPASSSP SSTDFSTCIV SLIRNNLHAE GWPKLQLGPQ TPAFNTAILQ 420
  421 RQLQYETLGD ILKRDFELVS DLSYIEFLFE SLKNDLPQFR SSIQESLLSL VGHLSILPQQ 480
  481 SKLKLKNLLR KNLSIDEQQR EDNNDAVNSI MALKFVSIKF TNAAFPFHDP EARLFNIWGT 540
  541 VRTNRFDIIE ESFKGLQPFW FRVNNASINT SATVKTSDLL GSHLSETEFP PFREFLQVLI 600
  601 DQLDSEAASI TRKSLNNAVR FSKQCLISNA IYGKKTMVIQ DEDWSVRIDK ALELDDTVVS 660
  661 RVNEMVQGMN DDIFIRYLTL LSNEFTATNS KGEQIAIFPY QDPIFGSVLL TLLNFVSNNV 720
  721 LRRLEILVPD LYHLVIMKFQ SLSDNDLAVC ATIIGIISTA IADSTHVKRI TKIAQSQTMA 780
  781 ETYVASYVVP RLYLKDQTNH IESDSILNLL NILTTHLSHP GTNKDMILKL VCQVTKFGLL 840
  841 LQVSAQERKD FLKKVMDTIQ DKLINDVTAI QTWSYLSLYS TDLENSSLFQ EKLLETNVSK 900
  901 QNDFLFSVGE SLSVVAGKWS SKYLIKQIDI PNFNVEIMQQ KFPATNVTTI LDEIFSGCDS 960
  961 TKPSLRKASC IWLLSYIQYL GHLPEVSSKC NDIHLRFMRF LADRDEFIQD SAARGLSLVY1020
 1021 EIGGSDLKES MVKGLLKSFT ESTAGSASTS ATGISGSVSE ETELFEPGVL NTGDGSISTY1080
 1081 KDILNLASEV GDPALVYKFM SLAKSSALWS SRKGIAFGLG AIMSKSSLEE LLLKDQQTAK1140
 1141 KLIPKLYRYR FDPFQAVSRS MTDIWNTLIP ESSLTISLYF NDILDELLCG MANKEWRVRE1200
 1201 ASTSALLQLI QSQPQEKFSE KMLKIWTMAF RTMDDIKDSV REVGTKFTTV LAKILARSID1260
 1261 VEKGVNPTKS KEILDNILPF LWGPHGLNSD AEEVRNFALT TLIDLVKHSP GAIKPFTPKL1320
 1321 IYDFITLFSS IEPQVINYLA LNAANYNIDA NVIDTQRKNG VTNSPLFQTI EKLINNSDDC1380
 1381 MMEEIINVVI KASRKSVGLP SKVASSLVII ILVKRYSIEM KPYSGKLLKV CLTMFEDRNE1440
 1441 SVNIAFAISM GYLFKVSALD KCIKYSEKLI TKYFEPTSTE NNKKVVGTAI DSILNYAKSE1500
 1501 FDNVASVFMP LIFIACNDED KDLETLYNKI WTEASSSGAG TVKLYLPEIL NVLCVNIKSN1560
 1561 DFSIRKTCAK SVIQLCGGIN DSIPYPQIVK LFDISREALS GRSWDGKEHI VAALVSLTEK1620
 1621 FSQTVADNND LQESINHVMY TEVSRKSMKY VKKILPLYAR YINVNPQEET ITFLIEKAKE1680
 1681 MIRLLGSESD DSEGSIKQTS DESTIKRIKP NTEITQKSSK ENIENEEYVI NLLKVSVDIC1740
 1741 NNSKSRYPMN LLEFIIDEIA YLFHNDRIIH TWRTQLAASE IGISIVGRFS TISSADFIQN1800
 1801 VGRLWDQTFP INCNKETIEN VKLQMIKFGG LIIQKIPSLQ NNIEENLRLL NSIDSTSRIE1860
 1861 LELKNIGL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CLU1 ECM29 NAS6 PRE5 RPN1 RPN10 RPN11 RPN12 RPN13 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 UBP6
    View Details Krogan NJ, et al. (2006) ADE2 BSC2 CWH41 DBF4 DIG1 ECM29 HAL5 LAA1 MRC1 OPI9 PEX32 PRP5 PTH2 RGA2 RMA1 RPN3 SIR1 STE12 THR1 TLG2 VPS45 YDL199C YEL057C YPL035C
    View Details Gavin AC, et al. (2006) ECM29 RPN1 RPN10 RPN11 RPN12 RPN13 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1
    View Details Gavin AC, et al. (2002) ADE4 ADH1 ASC1 BFR2 BLM10 BMH1 BMH2 BMS1 BRX1 BUD21 CBF5 CCT4 CDC6 CFT2 CKA1 CKA2 CKB1 CKB2 CLU1 CMS1 CRM1 CRN1 CSE1 DAM1 DBP8 DBP9 DHH1 DIA4 DIM1 DIP2 DIS3 DNA2 DUG1 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 EST3 FAP7 FIP1 FKS1 GCN1 GCN20 GEA2 GFA1 GLC7 HAS1 HCA4 HHF1, HHF2 HRP1 HSL1 HTA2 IDH2 IMP3 IMP4 INO4 KAP104 KAP123 KAP95 KRE33 KRR1 KTR3 LCB1 LCB2 LCP5 LTV1 LYS12 MDS3 MEC1 MET18 MIP6 MIR1 MIS1 MLH2 MPH1 MPP10 MRD1 MRPL23 MRPS28 MSH2 MSH6 MVD1 NAB2 NAB3 NAB6 NAN1 NAS6 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 NRD1 NUD1 PAP1 PDA1 PDB1 PFS2 PGK1 PNO1 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PRP43 PSE1 PTA1 PTI1 PUP3 PWP2 RAD23 RAD3 RAD34 RAD4 RAD52 RCL1 REF2 RFA1 RFA2 RGR1 RML2 RNA14 ROK1 ROM2 RPA135 RPN10 RPN11 RPN12 RPN13 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPP2B RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRP12 RRP7 RRP9 RTG2 SAM1 SAM2 SCL1 SEC21 SEC7 SEN54 SLC1 SLX9 SOF1 SPA2 SRO7 SRO9 SRP1 SRV2 SSL1 SUI3 SUP35 SUP45 TAO3 TFA1 TFB1 TFB4 TFP1 TIF1, TIF2 TSR1 TUB3 UBP6 ULP1 USO1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VAC14 VPS5 YDJ1 YFL006W YHR020W YJL017W YMR310C YOR059C YRA1 YSH1
    View Details Ho Y, et al. (2002) ADR1 BBC1 CDC39 CDC53 COP1 CRM1 DOP1 DUR1,2 ECM29 ECM33 FAA4 GAL3 GCN1 GYP5 HOM6 HRT1 HYP2 KAP122 MDN1 MET18 MKT1 MMS1 MYO2 PAA1 PFK1 PHO84 PMA2 PTC3 REP1 RPA135 RPA190 RPC40 RPN1 RPO31 RVS167 SRY1 TCB1 TDA10 TPS1 UBI4 UBP7 VPS13 YAR009C YER138C YGP1 YLR035C-A
    View Details Qiu et al. (2008) ECM29 RPN9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TID3 No Comments Cheeseman IM, et al. (2002)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ECM29 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] MSA 1.005972 View MSA. No confident structure predictions are available.
    2 View Details [152..525] deduced N/A No confident structure predictions are available.
    3 View Details [526..878] MSA 3.083968 View MSA. No confident structure predictions are available.
    4 View Details [879..1022] PSI-BLAST 46.0 Importin beta
    5 View Details [1023..1153] deduced N/A No confident structure predictions are available.
    6 View Details [1154..1629] MSA 19.377997 View MSA. No confident structure predictions are available.
    7 View Details [1630..1868] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  2.62777210765927 bayes_pls_golite062009
  • binding
    		•  2.26699794423696 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.954891553462304 bayes_pls_golite062009
  • protein binding
    		•  0.867374463164997 bayes_pls_golite062009
  • DNA binding
    		•  0.0652553830451623 bayes_pls_golite062009
    2
    Term Confidence Notes
  • hydrolase activity
    		•  2.5894939457048 bayes_pls_golite062009
  • binding
    		•  2.37294644142029 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.00618489031368 bayes_pls_golite062009
  • protein binding
    		•  0.992946510849437 bayes_pls_golite062009
  • DNA binding
    		•  0.0559585284546991 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle