YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: CDC39

General Information:
Name(s) found: CDC39 / YCR093W [SGD]
Description(s) found:
Found 19 descriptions.
SHOW ALL
  • Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2108 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    CCR4-NOT core complex [IPILink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [TASLink to PubMed article]
    response to pheromone involved in conjugation with cellular fusion [IMPLink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed article]
    nuclear-transcribed mRNA poly(A) tail shortening [IDALink to PubMed article]
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IPILink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: 3'-5'-exoribonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSATYRDLN TASNLETSKE KQAAQIVIAQ ISLLFTTLNN DNFESVEREI RHILDRSSVD  60
   61 IYIKVWERLL TLSSRDILQA GKFLLQENLL HRLLLEFAKD LPKKSTDLIE LLKERTFNNQ 120
  121 EFQKQTGITL SLFIDLFDKS ANKDIIESLD RSSQINDFKT IKMNHTNYLR NFFLQTTPET 180
  181 LESNLRDLLH SLEGESLNDL LALLLSEILS PGSQNLQNDP TRSWLTPPMV LDATNRGNVI 240
  241 ARSISSLQAN QINWNRVFNL MSTKYFLSAP LMPTTASLSC LFAALHDGPV IDEFFSCDWK 300
  301 VIFKLDLAIQ LHKWSVQNGC FDLLNAEGTR KVSETIPNTK QSLLYLLSIA SLNLELFLQR 360
  361 EELSDGPMLA YFQECFFEDF NYAPEYLILA LVKEMKRFVL LIENRTVIDE ILITLLIQVH 420
  421 NKSPSSFKDV ISTITDDSKI VDAAKIIINS DDAPIANFLK SLLDTGRLDT VINKLPFNEA 480
  481 FKILPCARQI GWEGFDTFLK TKVSPSNVDV VLESLEVQTK MTDTNTPFRS LKTFDLFAFH 540
  541 SLIEVLNKCP LDVLQLQRFE SLEFSLLIAF PRLINFGFGH DEAILANGDI AGINNDIEKE 600
  601 MQNYLQKMYS GELAIKDVIE LLRRLRDSDL PRDQEVFTCI THAVIAESTF FQDYPLDALA 660
  661 TTSVLFGSMI LFQLLRGFVL DVAFRIIMRF AKEPPESKMF KFAVQAIYAF RIRLAEYPQY 720
  721 CKDLLRDVPA LKSQAQVYQS IVEAATLANA PKERSRPVQE MIPLKFFAVD EVSCQINQEG 780
  781 APKDVVEKVL FVLNNVTLAN LNNKVDELKK SLTPNYFSWF STYLVTQRAK TEPNYHDLYS 840
  841 KVIVAMGSGL LHQFMVNVTL RQLFVLLSTK DEQAIDKKHL KNLASWLGCI TLALNKPIKH 900
  901 KNIAFREMLI EAYKENRLEI VVPFVTKILQ RASESKIFKP PNPWTVGILK LLIELNEKAN 960
  961 WKLSLTFEVE VLLKSFNLTT KSLKPSNFIN TPEVIETLSG ALGSITLEQQ QTEQQRQIIL1020
 1021 MQQHQQQMLI YQQRQQQQQQ RQQQQQHHIS ANTIADQQAA FGGEGSISHD NPFNNLLGST1080
 1081 IFVTHPDLKR VFQMALAKSV REILLEVVEK SSGIAVVTTT KIILKDFATE VDESKLKTAA1140
 1141 IIMVRHLAQS LARATSIEPL KEGIRSTMQS LAPNLMSLSS SPAEELDTAI NENIGIALVL1200
 1201 IEKASMDKST QDLADQLMQA IAIRRYHKER RADQPFITQN TNPYSLSLPE PLGLKNTGVT1260
 1261 PQQFRVYEEF GKNIPNLDVI PFAGLPAHAP PMTQNVGLTQ PQQQQAQMPT QILTSEQIRA1320
 1321 QQQQQQLQKS RLNQPSQSAQ PPGVNVPNPQ GGIAAVQSDL EQNQRVLVHL MDILVSQIKE1380
 1381 NATKNNLAEL GDQNQIKTII FQILTFIAKS AQKDQLALKV SQAVVNSLFA TSESPLCREV1440
 1441 LSLLLEKLCS LSLVARKDVV WWLVYALDSR KFNVPVIRSL LEVNLIDATE LDNVLVTAMK1500
 1501 NKMENSTEFA MKLIQNTVLS DDPILMRMDF IKTLEHLASS EDENVKKFIK EFEDTKIMPV1560
 1561 RKGTKTTRTE KLYLVFTEWV KLLQRVENND VITTVFIKQL VEKGVISDTD NLLTFVKSSL1620
 1621 ELSVSSFKES DPTDEVFIAI DALGSLIIKL LILQGFKDDT RRDYINAIFS VIVLVFAKDH1680
 1681 SQEGTTFNER PYFRLFSNIL YEWATIRTHN FVRISDSSTR QELIEFDSVF YNTFSGYLHA1740
 1741 LQPFAFPGFS FAWVTLLSHR MLLPIMLRLP NKIGWEKLML LIIDLFKFLD QYTSKHAVSD1800
 1801 AVSVVYKGTL RVILGISNDM PSFLIENHYE LMNNLPPTYF QLKNVILSAI PKNMTVPNPY1860
 1861 DVDLNMEDIP ACKELPEVFF DPVIDLHSLK KPVDNYLRIP SNSLLRTILS AIYKDTYDIK1920
 1921 KGVGYDFLSV DSKLIRAIVL HVGIEAGIEY KRTSSNAVFN TKSSYYTLLF NLIQNGSIEM1980
 1981 KYQIILSIVE QLRYPNIHTY WFSFVLMNMF KSDEWNDQKL EVQEIILRNF LKRIIVNKPH2040
 2041 TWGVSVFFTQ LINNNDINLL DLPFVQSVPE IKLILQQLVK YSKKYTTSEQ DDQSATINRR2100
 2101 QTPLQSNA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAF130 CAF40 CCR4 CDC39 POP2 RPN1 RPN11 RPN2 RPN8 SPG5
    View Details (MIPS) Mewes HW, et al. (2004) CAF16 CAF4 CCR4 CDC36 CDC39 DBF2 DHH1 IBA57 MOB1 MOT2 NOT3 NOT5 POP2
    View Details Krogan NJ, et al. (2006) CAF40 CCR4 CDC39 POP2
    View Details Gavin AC, et al. (2006) CAF40 CCR4 CDC39 POP2
    View Details Gavin AC, et al. (2002) AHA1 ATP11 CAF130 CAF40 CCR4 CCT6 CDC36 CDC39 COP1 FAS2 GCN1 MOT2 NOT3 NOT5 PDC1 POL1 POL12 POP2 PRI1 PRI2 RVB2 SAM1 SEC27 TFC7 TFP1 YRA1
    View Details Ho Y, et al. (2002) ADR1 AHP1 BBC1 CCR4 CDC36 CDC39 CDC53 CRM1 CYS4 DCS1 DCS2 DUR1,2 ECM29 ECM33 FAA4 GAL3 GCN1 GDB1 HRT1 HYP2 MDN1 MKT1 MMS1 MYO2 PFK1 PIL1 PMA2 POP2 RAD50 RNQ1 RPA190 RPN1 RVB1 STI1 TPS1 TSA2 UBI4 UBP15 UBR1 VPS1 VPS13 YAK1 YAR009C YGP1 YLR035C-A YLR241W YPL247C
    View Details Qiu et al. (2008) CAF16 CAF4 CAF40 CCR4 CDC36 CDC39 DBF2 DHH1 IBA57 MOB1 MOT2 NOT3 NOT5 POP2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DSN1 No Comments Hazbun TR, et al. (2003)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run NSE5 No Comments Hazbun TR, et al. (2003)
    View Run TAM41 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CDC39 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..527] deduced N/A No confident structure predictions are available.
    2 View Details [528..754] MSA 1.008947 View MSA. No confident structure predictions are available.
    3 View Details [755..880] deduced N/A No confident structure predictions are available.
    4 View Details [881..1076] MSA 1.008956 View MSA. No confident structure predictions are available.
    5 View Details [1077..1351] deduced N/A No confident structure predictions are available.
    6 View Details [1352..1772] MSA 1.010898 View MSA. No confident structure predictions are available.
    7 View Details [1773..2108] deduced N/A No confident structure predictions are available.
    8 View Details [1079..1286] MSA 1.046996 View MSA. No confident structure predictions are available.
    9 View Details [1287..1382] deduced N/A No confident structure predictions are available.
    10 View Details [1383..1457] deduced N/A No confident structure predictions are available.
    11 View Details [1458..1522] deduced N/A No confident structure predictions are available.
    12 View Details [1523..1709] deduced N/A No confident structure predictions are available.
    13 View Details [1710..1862] deduced N/A No confident structure predictions are available.
    14 View Details [1863..2108] MSA 1.058925 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.32

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle