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Protein Overview: YAK1

General Information:
Name(s) found: YAK1 / YJL141C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 807 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: protein amino acid phosphorylation [IDALink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSSNNNDSS SSNSNMNNSL SPTLVTHSDA SMGSGRASPD NSHMGRGIWN PSYVNQGSQR  60
   61 SPQQQHQNHH QQQQQQQQQQ QQNSQFCFVN PWNEEKVTNS QQNLVYPPQY DDLNSNESLD 120
  121 AYRRRKSSLV VPPARAPAPN PFQYDSYPAY TSSNTSLAGN SSGQYPSGYQ QQQQQVYQQG 180
  181 AIHPSQFGSR FVPSLYDRQD FQRRQSLAAT NYSSNFSSLN SNTNQGTNSI PVMSPYRRLS 240
  241 AYPPSTSPPL QPPFKQLRRD EVQGQKLSIP QMQLCNSKND LQPVLNATPK FRRASLNSKT 300
  301 ISPLVSVTKS LITTYSLCSP EFTYQTSKNP KRVLTKPSEG KCNNGFDNIN SDYILYVNDV 360
  361 LGVEQNRKYL VLDILGQGTF GQVVKCQNLL TKEILAVKVV KSRTEYLTQS ITEAKILELL 420
  421 NQKIDPTNKH HFLRMYDSFV HKNHLCLVFE LLSNNLYELL KQNKFHGLSI QLIRTFTTQI 480
  481 LDSLCVLKES KLIHCDLKPE NILLCAPDKP ELKIIDFGSS CEEARTVYTY IQSRFYRAPE 540
  541 IILGIPYSTS IDMWSLGCIV AELFLGIPIF PGASEYNQLT RIIDTLGYPP SWMIDMGKNS 600
  601 GKFMKKLAPE ESSSSTQKHR MKTIEEFCRE YNIVEKPSKQ YFKWRKLPDI IRNYRYPKSI 660
  661 QNSQELIDQE MQNRECLIHF LGGVLNLNPL ERWTPQQAML HPFITKQEFT GEWFPPGSSL 720
  721 PGPSEKHDDA KGQQSEYGSA NDSSNNAGHN YVYNPSSATG GADSVDIGAI SKRKENTSGD 780
  781 ISNNFAVTHS VQEGPTSAFN KLHIVEE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AHP1 BMS1 CDC39 CDC53 CIC1 COF1 CTF4 DBP10 DCS1 DCS2 DED81 DIA2 DNM1 ECM10 ELA1 ENP1 FPR3 GDB1 ILS1 KRE33 KRI1 LSP1 LST4 MCM2 MCM3 MCM5 MSS116 NIP7 NMD3 NOP12 PIL1 RAD50 RPF2 RRP12 SEH1 SKP1 SLT2 SPB1 SSF1 SSF2 SSZ1 TIF6 TSA2 UBP15 UBR1 URB1 UTP10 VPS1 YAK1 YBL104C YLR241W YPL247C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HRT1 YAK1 2 Uetz P, et al. (2000)
    View Screen PRE4 YAK1 2 Unpublished Fields Lab Data
    View Screen GTS1 YAK1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..339] deduced N/A No confident structure predictions are available.
    2 View Details [340..451] PSI-BLAST 434.0 Cyclin-dependent PK, CDK2
    3 View Details [452..531]
    [655..661]    		 PSI-BLAST 434.0 Cyclin-dependent PK, CDK2
    4 View Details [532..581] PSI-BLAST 434.0 Cyclin-dependent PK, CDK2
    5 View Details [582..654] PSI-BLAST 434.0 Cyclin-dependent PK, CDK2
    6 View Details [662..807] ORFEUS 10.52 Glycogen synthase kinase-3 beta (Gsk3b)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle