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Protein Overview: TIF6

General Information:
Name(s) found: TIF6 / YPR016C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 245 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    nuclear outer membrane [IGILink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: ribosomal subunit export from nucleus [IGILink to PubMed article]
    ribosomal large subunit biogenesis [IMPLink to PubMed article][IPILink to PubMed article]
    processing of 27S pre-rRNA [IMPLink to PubMed article]
    Molecular Function: ribosomal large subunit binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATRTQFENS NEIGVFSKLT NTYCLVAVGG SENFYSAFEA ELGDAIPIVH TTIAGTRIIG  60
   61 RMTAGNRRGL LVPTQTTDQE LQHLRNSLPD SVKIQRVEER LSALGNVICC NDYVALVHPD 120
  121 IDRETEELIS DVLGVEVFRQ TISGNILVGS YCSLSNQGGL VHPQTSVQDQ EELSSLLQVP 180
  181 LVAGTVNRGS SVVGAGMVVN DYLAVTGLDT TAPELSVIES IFRLQDAQPE SISGNLRDTL 240
  241 IETYS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARX1 BUD20 CIC1 DBP10 DRS1 ERB1 HAS1 IPI3 MAK21 MRT4 NIP7 NOC2 NOC3 NOG1 NOG2 NOP15 NOP2 NOP4 NOP7 NSA1 NSA2 NUG1 PUF6 RIX1 RLP7 RPF1 RPF2 RPL25 RPL36B RSA4 SDA1 SPB1 SPB4 SSF1 TIF6 YTM1
    View Details Gavin AC, et al. (2006) ARX1 FPR4 MRT4 NIP7 NOG1 NOG2 NOP2 NSA2 NUG1 RPF2 SDA1 TIF6
    View Details Gavin AC, et al. (2002) ARX1 BEM2 BMS1 BRX1 BUD20 CCL1 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DCS2 DRS1 EBP2 ERB1 FAP1 FPR1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KAP95 KIN28 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRPS28 MRT4 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SNU13 SPB1 SPB4 SPT7 SSF1 SSL1 TFA1 TFB1 TFB3 TFB4 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) AAC3 ACO1 AHP1 APA1 APL2 APL4 APM1 ARP4 ASA1 ATG17 ATG29 ATG7 ATP3 BMS1 BRX1 CBF5 CBP2 CCT6 CDC14 CDC33 CDC53 CIC1 CIS1 CKA1 CKA2 CKB1 CKB2 COF1 CTF4 CYS4 DBP10 DBP2 DBP7 DED81 DIA2 DNL4 DRS1 EBP2 EGD1 EGD2 ENP1 ENP2 ERB1 EXG1 FOL2 FPR3 FPR4 GAR1 GDE1 GND1 GRH1 GUS1 HAP2 HAP5 HAS1 HHF1, HHF2 HHT1, HHT2 HOT1 HTA1 HTB1 HTB2 HUL5 HXT7 HYP2 ILS1 IPP1 KAP95 KGD1 KRE33 KRI1 KRR1 LOC1 LSM2 LSM8 LST4 MAK11 MAK16 MAM33 MCM2 MCM3 MCM5 MET6 MGM101 MNP1 MRT4 MSS116 MTQ1 MUB1 NAP1 NIP7 NMA1 NMD3 NMD5 NOC2 NOC3 NOG1 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NSA1 NSA2 NUG1 PAB1 PDI1 PIB2 POB3 POL5 PRP43 PSE1 PTC5 PUF6 PWP1 QCR2 RCL1 RGI1 RHR2 RLP7 RPF2 RPL5 RPN12 RPN8 RPP0 RRP1 RRP12 RRP15 RRP17 RRP42 RRP5 RRT6 RTC3 SAH1 SAP190 SCS2 SEC53 SEH1 SKP1 SLT2 SMB1 SPB1 SPB4 SPE3 SPT16 SRP1 SSF1 SSF2 SSK2 SSQ1 SSZ1 THI21 TIF1, TIF2 TIF4631 TIF6 TSR1 TUF1 UBR2 ULS1 URB1 URB2 UTP10 YAK1 YBL104C YER084W YGL117W YLR287C YRA1 YRA2 YTM1
    View Details Qiu et al. (2008) GAR1 KRE33 NOP12 NSR1 NUG1 RCL1 RPL27A RRP5 TIF6 UTP15

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TIF6 Huh WK, et al. (2003)
    View Data TIF6 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..245] PSI-BLAST 1301.0 Ribosome anti-association factor eIF6 (aIF6)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • translation initiation factor activity
    		•  2.82313826209658 bayes_pls_golite062009
  • ribosomal large subunit binding
    		•  2.29551693750603 bayes_pls_golite062009
  • binding
    		•  1.48640777619976 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.14138534491569 bayes_pls_golite062009
  • hydrolase activity
    		•  1.05437300113124 bayes_pls_golite062009
  • catalytic activity
    		•  0.889920589881492 bayes_pls_golite062009
  • protein binding
    		•  0.21271994410782 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle