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Protein Overview: APA1

General Information:
Name(s) found: APA1 / YCL050C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 321 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: nucleotide metabolic process [TASLink to PubMed article]
    Molecular Function: bis(5'-nucleosyl)-tetraphosphatase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIPADIASL ISDKYKSAFD NGNLKFIQTE TTKTKDPKTS MPYLISHMPS LIEKPERGQT  60
   61 PEGEDPLGKP EEELTVIPEF GGADNKAYKL LLNKFPVIPE HTLLVTNEYQ HQTDALTPTD 120
  121 LLTAYKLLCA LDNEESDKRH MVFYNSGPAS GSSLDHKHLQ ILQMPEKFVT FQDRLCNGKE 180
  181 HFLPTFNTEP LQDAKVSFAH FVLPMPESEE TVDEDLLAMC YISILQRALT FFQDWLNENP 240
  241 ELKKSYNLML TKEWICVVPR SKAFSDEMKI GFNSTGYCGM ILTKNDEVFS KITEKPELIN 300
  301 DILLECGFPN TSGQKPNEYN Y

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) APA1 GAR1 LSM2 LSM8 QCR2 RPN12 RPN8 RRP42 SMB1 TIF6 YGL117W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data APA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] ORFEUS 7.22 Galactose-1-phosphate uridylyltransferase
    2 View Details [186..321] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  1.74990165024183 bayes_pls_golite062009
  • binding
    		•  1.71599870633602 bayes_pls_golite062009
  • hydrolase activity
    		•  0.690968602046843 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.342529552808262 bayes_pls_golite062009
  • protein binding
    		•  0.315946879872005 bayes_pls_golite062009
  • catalytic activity
    		•  0.096119422680995 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle