YRC Public Data Repository - Protein Structure Prediction

Protein:	TIF6
Organism:	Saccharomyces cerevisiae
Length:	245 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIF6.

Description	E-value	Query Range	Subject Range
gi\|114681677, gi... - gi\|55651966\|ref\|XP_514603.1\| PREDICTED: integrin beta 4 binding protein isoform 8 [Pan troglodytes],... EIF6 - eukaryotic translation initiation factor 6 gi\|123998271, gi... - gi\|208966236\|dbj\|BAG73132.1\| eukaryotic translation initiation factor 6 [synthetic construct], gi\|12...	0.0	[1..245]	[1..245]
gi\|6381991 - gi\|6381991\|gb\|AAF07396.1\|AF108462_1 b4 integrin interactor homolog [Mus musculus]	0.0	[1..245]	[1..245]
gi\|29436495, gi\|... - gi\|41055624\|ref\|NP_957238.1\| eukaryotic translation initiation factor 6 [Danio rerio], gi\|29436495\|g...	0.0	[1..245]	[1..245]
gi\|113611953, gi... - gi\|51963598\|ref\|XP_506503.1\| PREDICTED OJ1340_C08.131 gene product [Oryza sativa (japonica cultivar-... gi\|125559329 - gi\|125559329\|gb\|EAZ04865.1\| hypothetical protein OsI_27044 [Oryza sativa Indica Group]	0.0	[1..244]	[1..244]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..245]	[1..245]
IF62_ARATH - Eukaryotic translation initiation factor 6-2 OS=Arabidopsis thaliana GN=EIF6-2 PE=2 SV=1	0.0	[1..244]	[1..244]
TIF6 - Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 ... gi\|151942805 - gi\|151942805\|gb\|EDN61151.1\| translation initiation factor [Saccharomyces cerevisiae YJM789] gi\|190407960 - gi\|190407960\|gb\|EDV11225.1\| eukaryotic translation initiation factor 6 [Saccharomyces cerevisiae RM1... gi\|207340407 - gi\|207340407\|gb\|EDZ68768.1\| YPR016Cp-like protein [Saccharomyces cerevisiae AWRI1631] IF6_YEAST - Eukaryotic translation initiation factor 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...	0.0	[1..245]	[1..245]
gi\|220953962, gi... - gi\|220960032\|gb\|ACL92552.1\| eIF6-PA [synthetic construct], gi\|220953962\|gb\|ACL89524.1\| eIF6-PA [synt... eIF6-PA - The gene eIF6 is referred to in FlyBase by the symbol Dmel\eIF6 (CG17611, FBgn0034915). It is a prot...	0.0	[1..244]	[1..244]

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Predicted Domain #1

Region A:
Residues: [1-245]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATRTQFENS NEIGVFSKLT NTYCLVAVGG SENFYSAFEA ELGDAIPIVH TTIAGTRIIG  60
   61 RMTAGNRRGL LVPTQTTDQE LQHLRNSLPD SVKIQRVEER LSALGNVICC NDYVALVHPD 120
  121 IDRETEELIS DVLGVEVFRQ TISGNILVGS YCSLSNQGGL VHPQTSVQDQ EELSSLLQVP 180
  181 LVAGTVNRGS SVVGAGMVVN DYLAVTGLDT TAPELSVIES IFRLQDAQPE SISGNLRDTL 240
  241 IETYS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1301.0
Match:	1g62A_
Description:	Ribosome anti-association factor eIF6 (aIF6)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	2.82313826209658	bayes_pls_golite062009
ribosomal large subunit binding	2.29551693750603	bayes_pls_golite062009
binding	1.48640777619976	bayes_pls_golite062009
nucleic acid binding	1.14138534491569	bayes_pls_golite062009
hydrolase activity	1.05437300113124	bayes_pls_golite062009
catalytic activity	0.889920589881492	bayes_pls_golite062009
protein binding	0.21271994410782	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: