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Protein Overview: SAP190

General Information:
Name(s) found: SAP190 / YKR028W [SGD]
Description(s) found:
Found 13 descriptions.
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  • Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1098 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IPILink to PubMed article]
    Biological Process: G1/S transition of mitotic cell cycle [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein serine/threonine phosphatase activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSFWKFGQ DYSIESPVSK ILNSAFIKIN KDQDDDVPTG TCEENIADDE DNSSHDYAAS  60
   61 EDNVVNENEE KEEENTLPTT ESEYENYRPN LDVLDDLLDD DELYTELMCS NFKLLIFLKY 120
  121 PDVLSKLIEY VTNEKILDEE TDSAKKPEII EGVNDHPILI ERDRKDKKED AEEGGDSEET 180
  181 TNDSDHDSGD ERSVDSEETS ITLPPESEEQ VETRRARIAA EILSADVWPI SAAIMQNKDL 240
  241 LGRLWSILDH PAPLPIPAST YFMKINERLL DMDITGMLEF ILSRDSLVAR FLTHVDNPSL 300
  301 MDFLLKVIST DKPDSPTGVI KILKSQELIP KLLDHLNPEY GISTQSAAGD FIKAFVTLST 360
  361 NSSNELASGI GPNELTRQLV SEEMIEKLIK IMLKGGTSLS NGVGIIIELI RKNNSDYDFI 420
  421 QLVYTTLESH PPTDRDPIHL IHLVKLFAKH MPDFADMLDK TKLPLMEMPF GNIEPLGFER 480
  481 FKICELIAEL LHCSNMTLLN EPNGEMIAQE RDIERAKELE TSTEKENITA IVDNKSSYYD 540
  541 KDCVEKDITE NLGALQINNQ GSEEDELNDT GVSSVKLDVK SDAKVVEGLE NDASGVELYD 600
  601 ETLSDTESVR ECLREKPLVG DRLKIALEDT KILISILDMF TEFPWNNFLH NVIFDIAQQI 660
  661 FNGPLKTGYN RFLLKDYLVD AYLTKKIVDA DKACQDYEKK TGLRYGYMGH LTLVAEEISK 720
  721 FKEYIDEMKL TFCNTAVSDR LEEPFWKEYS ETILADTREK YNTVLGDFGN DQESDDDVIR 780
  781 NSDSEDIIGD TEGNENYGNG ENDELLSNGH DSGNMDLYYN FNNNENEENE EDYAEYSDVD 840
  841 NKNYYNNVET NDDDYDSDDG KSKSAESEFT DKISEHRDGN SLYNEDNDEN GSDKWTSGTS 900
  901 LFPPDHFPSR SQPSDPKLQD QNIFHHQFDF EGVGDDDDYM DPNDDGQSYA RPGNPLYTTP 960
  961 KTPPRPKTIL FNSLSALDNN GEDEEVALGT SVDDRMDNEI SSDEEDSEMK MKRMIWAMRR1020
 1021 ATHYIGQEVK KLSELKHSHC HIFTLYSSIF YCSTFFAYRS FIIHQIYTFL IEACNLILTE1080
 1081 YNLIKNNEYS LLNILKFI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SAP155 SAP185 SAP190 SIT4
    View Details Krogan NJ, et al. (2006) SAP190 SSD1 ZRG8
    View Details Gavin AC, et al. (2006) DIG1 SAP190
    View Details Gavin AC, et al. (2002) ACC1 AVT4 BEM2 CCT2 CDC25 FAB1 HRK1 MDS3 MIA40 MRPL3 SAP155 SAP185 SAP190 SIT4 SWT21
    View Details Ho Y, et al. (2002) AAC3 ABP1 ACC1 ACO1 ADO1 AIM41 ARP2 ARP4 ASA1 ATG17 ATG29 ATP3 ATP4 BGL2 BUD14 CAR2 CCT6 CDC33 CIC1 CIS1 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 DOG1 EDC3 EDE1 EGD2 ENP1 FAA1 FAA4 FET4 FOL2 FPR3 GAS1 GCN3 GLT1 GPH1 GRH1 GSF2 HAP2 HAP5 HAS1 HHF1, HHF2 HRR25 HSP104 HXT5 HXT7 HYP2 INP52 IPP1 LOC1 LSP1 LTV1 MAE1 MAM33 MDH1 MDS3 MGE1 MTQ1 NAP1 NDE1 NMD5 NOP16 NPA3 NSA1 NSA2 NUG1 OYE2 PEX19 PIL1 PIM1 PIN4 POL5 POR1 PRP8 PSE1 PTC4 PUF3 QCR2 RHR2 RIO2 RMT2 RNH202 RNQ1 RNR2 RPC19 RPM2 RPT4 SAH1 SAP155 SAP185 SAP190 SAS10 SEC2 SEC23 SES1 SFB3 SGM1 SIT4 SNP1 SPE3 SRP1 SSK2 TAP42 TIF1, TIF2 TIF6 TMA19 TSR1 VAC14 VMA4 YBR225W YER138C YHB1 YMR196W YRA1 YRA2 YTM1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [89..577] MSA 5.02491 View MSA. No confident structure predictions are available.
    3 View Details [578..770] MSA 1.022982 View MSA. No confident structure predictions are available.
    4 View Details [771..1003] MSA 7.029997 View MSA. No confident structure predictions are available.
    5 View Details [1004..1098] deduced N/A Confident ab initio structure predictions are available.
    6 View Details [776..1098] FFAS03 1.01 Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle