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Protein Overview: NDE1

General Information:
Name(s) found: NDE1 / YMR145C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 560 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Biological Process: NADH oxidation [IDALink to PubMed article]
    glucose catabolic process to ethanol [IMPLink to PubMed articleLink to PubMed article]
    chronological cell aging [IMPLink to PubMed article]
    Molecular Function: NADH dehydrogenase activity [IDALink to PubMed articleLink to PubMed article][ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRQSLMKTV WANSSRFSLQ SKSGLVKYAK NRSFHAARNL LEDKKVILQK VAPTTGVVAK  60
   61 QSFFKRTGKF TLKALLYSAL AGTAYVSYSL YREANPSTQV PQSDTFPNGS KRKTLVILGS 120
  121 GWGSVSLLKN LDTTLYNVVV VSPRNYFLFT PLLPSTPVGT IELKSIVEPV RTIARRSHGE 180
  181 VHYYEAEAYD VDPENKTIKV KSSAKNNDYD LDLKYDYLVV GVGAQPNTFG TPGVYEYSSF 240
  241 LKEISDAQEI RLKIMSSIEK AASLSPKDPE RARLLSFVVV GGGPTGVEFA AELRDYVDQD 300
  301 LRKWMPELSK EIKVTLVEAL PNILNMFDKY LVDYAQDLFK EEKIDLRLKT MVKKVDATTI 360
  361 TAKTGDGDIE NIPYGVLVWA TGNAPREVSK NLMTKLEEQD SRRGLLIDNK LQLLGAKGSI 420
  421 FAIGDCTFHP GLFPTAQVAH QEGEYLAQYF KKAYKIDQLN WKMTHAKDDS EVARLKNQIV 480
  481 KTQSQIEDFK YNHKGALAYI GSDKAIADLA VGEAKYRLAG SFTFLFWKSA YLAMCLSFRN 540
  541 RVLVAMDWAK VYFLGRDSSI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BGL2 FAA1 NDE1
    View Details (MIPS) Mewes HW, et al. (2004) AIM45 ALD4 CIR1 CIR2 CIT1 CYB2 DLD1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1 SDH1
    View Details Ho Y, et al. (2002) ACC1 ADH4 ADR1 ARC1 ARP2 AYR1 BGL2 CBP6 CCT6 ENP1 FAA1 FAA4 FRS2 GAR1 GCD11 GCN3 GLT1 GSF2 GSP1 HEM15 HRP1 HTA2 HXT7 KAP104 KTR3 MAE1 MCX1 MRT4 NAB2 NDE1 NPA3 OAC1 PAA1 PET10 PET9 PSD1 RMT2 RNR2 RPT4 SAP155 SAP185 SAP190 SIT4 SLC1 TAP42 TFG2 TRP3 TRP5 VMA8 VPS8 YDL063C YHM2 YMR196W YNL035C
    View Details Qiu et al. (2008) ALD4 CIR1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NOP9 No Comments Hazbun TR, et al. (2003)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NDE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] PSI-BLAST 4.0 Flavocytochrome c sulfide dehydrogenase, FCSD, flavin-binding subunit
    2 View Details [103..144]
    [182..225]
    [384..458]    		 PSI-BLAST 119.68867 Dihydrolipoamide dehydrogenase
    3 View Details [145..181]
    [226..383]
    [459..466]    		 PSI-BLAST 119.68867 Dihydrolipoamide dehydrogenase
    4 View Details [467..560] PSI-BLAST 119.68867 Dihydrolipoamide dehydrogenase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.52

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle