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Protein Overview: CIR2

General Information:
Name(s) found: CIR2 / YOR356W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 631 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    Biological Process: NAD catabolic process [IPILink to PubMed article]
    Molecular Function: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKFTNENLI RGIRMTISAK SRHLALGTDM TRKFSLSCRF LNKANLTEEE KELLNEPRAR  60
   61 DYVDVCIVGG GPAGLATAIK LKQLDNSSGT GQLRVVVLEK SSVLGGQTVS GAILEPGVWK 120
  121 ELFPDEKSDI GIPLPKELAT LVTKEHLKFL KGKWAISVPE PSQMINKGRN YIVSLNQVVG 180
  181 YLGEKAEEVG VEVYPGIAVS DLIYDENNAV KGVITKDAGI SKSGKPKETF ERGMEFWARQ 240
  241 TVLAEGCHGS LTKQALAKYD LRKGRQHQTY GLGIKEVWEV KPENFNKGFA AHTMGYPLTN 300
  301 DVYGGGFQYH FGDGLVTVGL VVGLDYKNPY VSPYKEFQKM KHHPYYSKVL EGGKCIAYAA 360
  361 RALNEGGLQS VPKLNFPGGV LVGASAGFMN VPKIKGTHTA MKSGLLAAES IFESIKGLPV 420
  421 LEEVEDEDAK MAMFDKEATI NLESYESAFK ESSIYKELYE VRNIRPSFSG KLGGYGGMIY 480
  481 SGIDSLILKG KVPWTLKFDE KNDGEILEPA SKYKPIEYPK PDGVISFDIL TSVSRTGTYH 540
  541 DDDEPCHLRV PGQDMVKYAE RSFPVWKGVE SRFCPAGVYE FVKDEKSPVG TRLQINSQNC 600
  601 IHCKTCDIKA PRQDITWKVP EGGDGPKYTL T

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AIM45 ALD4 CIR1 CIR2 CIT1 CYB2 DLD1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1 SDH1
    View Details Gavin AC, et al. (2002) CIR2 PUS7
    View Details Qiu et al. (2008) CIR2 GUT2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CIR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..138]
    [175..264]
    [369..438]    		 PSI-BLAST 39.69897 p-Hydroxybenzoate hydroxylase, PHBH; p-Hydroxybenzoate hydroxylase (PHBH)
    2 View Details [139..174]
    [265..368]
    [439..499]    		 PSI-BLAST 39.69897 p-Hydroxybenzoate hydroxylase, PHBH; p-Hydroxybenzoate hydroxylase (PHBH)
    3 View Details [500..631] MSA 13.069997 View MSA. Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • NADH dehydrogenase activity
    		•  6.5929955386305 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  6.45562261241375 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  6.34963309803617 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  5.69483449389334 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  4.45434904225178 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.38767199872766 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  3.11137503143637 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.04960158864768 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.87261684242536 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  2.79579164562277 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
    		•  2.25002926602325 bayes_pls_golite062009
  • electron-transferring-flavoprotein dehydrogenase activity
    		•  1.55451764082771 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.45104542724719 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  1.35744482443829 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.31328088143083 bayes_pls_golite062009
  • transporter activity
    		•  1.29839290134235 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
    		•  1.08975609376408 bayes_pls_golite062009
  • binding
    		•  1.08897727611544 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07862908893913 bayes_pls_golite062009
  • catalytic activity
    		•  1.03127962968326 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  0.69501605197281 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  0.643810447309487 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.556967966402473 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.31459693204333 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.301257942260531 bayes_pls_golite062009
  • protein binding
    		•  0.247306689726508 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.162130833238942 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.10059033442163 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.0724852054074128 bayes_pls_golite062009
  • DNA binding
    		•  0.022476246602636 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle