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Protein Overview: DLD1

General Information:
Name(s) found: DLD1 / YDL174C [SGD]
Description(s) found:
Found 27 descriptions.
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  • D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 587 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: carbohydrate metabolic process [IMPLink to PubMed article]
    aerobic respiration [IMPLink to PubMed article]
    Molecular Function: D-lactate dehydrogenase (cytochrome) activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLWKRTCTRL IKPIAQPRGR LVRRSCYRYA STGTGSTDSS SQWLKYSVIA SSATLFGYLF  60
   61 AKNLYSRETK EDLIEKLEMV KKIDPVNSTL KLSSLDSPDY LHDPVKIDKV VEDLKQVLGN 120
  121 KPENYSDAKS DLDAHSDTYF NTHHPSPEQR PRIILFPHTT EEVSKILKIC HDNNMPVVPF 180
  181 SGGTSLEGHF LPTRIGDTIT VDLSKFMNNV VKFDKLDLDI TVQAGLPWED LNDYLSDHGL 240
  241 MFGCDPGPGA QIGGCIANSC SGTNAYRYGT MKENIINMTI VLPDGTIVKT KKRPRKSSAG 300
  301 YNLNGLFVGS EGTLGIVTEA TVKCHVKPKA ETVAVVSFDT IKDAAACASN LTQSGIHLNA 360
  361 MELLDENMMK LINASESTDR CDWVEKPTMF FKIGGRSPNI VNALVDEVKA VAQLNHCNSF 420
  421 QFAKDDDEKL ELWEARKVAL WSVLDADKSK DKSAKIWTTD VAVPVSQFDK VIHETKKDMQ 480
  481 ASKLINAIVG HAGDGNFHAF IVYRTPEEHE TCSQLVDRMV KRALNAEGTC TGEHGVGIGK 540
  541 REYLLEELGE APVDLMRKIK LAIDPKRIMN PDKIFKTDPN EPANDYR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AIM45 ALD4 CIR1 CIR2 CIT1 CYB2 DLD1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1 SDH1
    View Details Qiu et al. (2008) CYB2 DLD1 GUT2 QCR8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DLD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] deduced N/A No confident structure predictions are available.
    2 View Details [101..327]
    [535..587]    		 PSI-BLAST 105.69897 Flavoprotein subunit of p-cresol methylhydroxylase
    3 View Details [328..534] PSI-BLAST 105.69897 Flavoprotein subunit of p-cresol methylhydroxylase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle