YRC Public Data Repository - Protein Structure Prediction

Protein:	DLD1
Organism:	Saccharomyces cerevisiae
Length:	587 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DLD1.

Description	E-value	Query Range	Subject Range
DLD1_YEAST - D-lactate dehydrogenase [cytochrome] 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 20450... DLD1 - D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed ... gi\|151941831 - gi\|151941831\|gb\|EDN60187.1\| D-lactate ferricytochrome c oxidoreductase [Saccharomyces cerevisiae YJM... gi\|190405170 - gi\|190405170\|gb\|EDV08437.1\| D-lactate ferricytochrome c oxidoreductase [Saccharomyces cerevisiae RM1...	0.0	[1..587]	[1..587]
DLD1_KLULA - D-lactate dehydrogenase [cytochrome], mitochondrial OS=Kluyveromyces lactis GN=DLD1 PE=3 SV=2 DLD1_KLULA - D-lactate dehydrogenase [cytochrome], mitochondrial OS=Kluyveromyces lactis (strain ATCC 8585 / CBS ...	0.0	[5..575]	[13..567]
DLD_ARATH - D-lactate dehydrogenase [cytochrome], mitochondrial OS=Arabidopsis thaliana GN=DLD PE=1 SV=1	0.0	[49..577]	[58..563]
gi\|25323092 - pir\|\|D97606 glycolate oxidase chain D-like, D-lactate dehydrogenase-like (AP002543) [imported] - Agr... gi\|15889339, gi\|... - gi\|15889339\|ref\|NP_355020.1\| hypothetical protein AGR_C_3718 [Agrobacterium tumefaciens str. C58], g...	0.0	[88..576]	[6..475]
gi\|11279881 - pir\|\|G81327 probable glycolate oxidase chain D Cj1213c [imported] - Campylobacter jejuni (strain NCT... gi\|112360531, gi... - gi\|6968646\|emb\|CAB73467.1\| putative glycolate oxidase subunit D [Campylobacter jejuni subsp. jejuni ... gi\|88596835, gi\|... - gi\|88596835\|ref\|ZP_01100072.1\| glycolate oxidase, subunit GlcD [Campylobacter jejuni subsp. jejuni 8... gi\|86150362, gi\|... - gi\|86150362\|ref\|ZP_01068588.1\| glycolate oxidase, subunit GlcD [Campylobacter jejuni subsp. jejuni C...	0.0	[107..574]	[2..458]
gi\|25323065 - pir\|\|B83991 glycolate oxidase subunit BH2730 [imported] - Bacillus halodurans (strain C-125) gi\|10175351, gi\|... - gi\|15615293\|ref\|NP_243596.1\| glycolate oxidase subunit [Bacillus halodurans C-125], gi\|10175351\|dbj\|...	0.0	[112..581]	[8..464]
gi\|17429686 - gi\|17429686\|emb\|CAD16371.1\| putative d-lactate dehydrogenase (cytochrome) oxidoreductase protein [Ra... gi\|17547383 - gi\|17547383\|ref\|NP_520785.1\| putative D-lactate dehydrogenase (cytochrome) oxidoreductase protein [R...	0.0	[107..576]	[16..471]
gi\|221315135 - gi\|221315135\|ref\|ZP_03596940.1\| hypothetical protein BsubsN3_15562 [Bacillus subtilis subsp. subtili... GLCD_BACSU - Glycolate oxidase subunit GlcD OS=Bacillus subtilis (strain 168) GN=glcD PE=3 SV=1 gi\|221324335 - gi\|221324335\|ref\|ZP_03605629.1\| hypothetical protein BsubsS_15627 [Bacillus subtilis subsp. subtilis... GLCD_BACSU - Glycolate oxidase subunit glcD OS=Bacillus subtilis GN=glcD PE=3 SV=1 gi\|221320053 - gi\|221320053\|ref\|ZP_03601347.1\| hypothetical protein BsubsJ_15468 [Bacillus subtilis subsp. subtilis...	0.0	[107..581]	[3..464]

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Predicted Domain #1

Region A:
Residues: [1-100]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLWKRTCTRL IKPIAQPRGR LVRRSCYRYA STGTGSTDSS SQWLKYSVIA SSATLFGYLF  60
   61 AKNLYSRETK EDLIEKLEMV KKIDPVNSTL KLSSLDSPDY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [101-327]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHDPVKIDKV VEDLKQVLGN KPENYSDAKS DLDAHSDTYF NTHHPSPEQR PRIILFPHTT  60
   61 EEVSKILKIC HDNNMPVVPF SGGTSLEGHF LPTRIGDTIT VDLSKFMNNV VKFDKLDLDI 120
  121 TVQAGLPWED LNDYLSDHGL MFGCDPGPGA QIGGCIANSC SGTNAYRYGT MKENIINMTI 180
  181 VLPDGTIVKT KKRPRKSSAG YNLNGLFVGS EGTLGIVTEA TVKCHVK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [535-587]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVGIGKREYL LEELGEAPVD LMRKIKLAID PKRIMNPDKI FKTDPNEPAN DYR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	105.69897
Match:	1diiA_
Description:	Flavoprotein subunit of p-cresol methylhydroxylase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [328-534]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKAETVAVVS FDTIKDAAAC ASNLTQSGIH LNAMELLDEN MMKLINASES TDRCDWVEKP  60
   61 TMFFKIGGRS PNIVNALVDE VKAVAQLNHC NSFQFAKDDD EKLELWEARK VALWSVLDAD 120
  121 KSKDKSAKIW TTDVAVPVSQ FDKVIHETKK DMQASKLINA IVGHAGDGNF HAFIVYRTPE 180
  181 EHETCSQLVD RMVKRALNAE GTCTGEH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	105.69897
Match:	1diiA_
Description:	Flavoprotein subunit of p-cresol methylhydroxylase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits