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Protein Overview: CYB2

General Information:
Name(s) found: CYB2 / YML054C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 591 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial intermembrane space [IDALink to PubMed articleLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: electron transport [TASLink to PubMed article]
    Molecular Function: L-lactate dehydrogenase (cytochrome) activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKYKPLLKI SKNCEAAILR ASKTRLNTIR AYGSTVPKSK SFEQDSRKRT QSWTALRVGA  60
   61 ILAATSSVAY LNWHNGQIDN EPKLDMNKQK ISPAEVAKHN KPDDCWVVIN GYVYDLTRFL 120
  121 PNHPGGQDVI KFNAGKDVTA IFEPLHAPNV IDKYIAPEKK LGPLQGSMPP ELVCPPYAPG 180
  181 ETKEDIARKE QLKSLLPPLD NIINLYDFEY LASQTLTKQA WAYYSSGAND EVTHRENHNA 240
  241 YHRIFFKPKI LVDVRKVDIS TDMLGSHVDV PFYVSATALC KLGNPLEGEK DVARGCGQGV 300
  301 TKVPQMISTL ASCSPEEIIE AAPSDKQIQW YQLYVNSDRK ITDDLVKNVE KLGVKALFVT 360
  361 VDAPSLGQRE KDMKLKFSNT KAGPKAMKKT NVEESQGASR ALSKFIDPSL TWKDIEELKK 420
  421 KTKLPIVIKG VQRTEDVIKA AEIGVSGVVL SNHGGRQLDF SRAPIEVLAE TMPILEQRNL 480
  481 KDKLEVFVDG GVRRGTDVLK ALCLGAKGVG LGRPFLYANS CYGRNGVEKA IEILRDEIEM 540
  541 SMRLLGVTSI AELKPDLLDL STLKARTVGV PNDVLYNEVY EGPTLTEFED A

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AIM45 ALD4 CIR1 CIR2 CIT1 CYB2 DLD1 FUM1 GUT2 MDH1 NDE1 NDE2 NDI1 SDH1
    View Details Qiu et al. (2008) COB COX1 COX2 COX3 COX8 CYB2 CYC1 CYC7 DLD1 MCR1 NDI1 QCR8 RIP1 SDH1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79] deduced N/A No confident structure predictions are available.
    2 View Details [80..176] PSI-BLAST 10156.0 Flavocytochrome b2, C-terminal domain; Flavocytochrome b2, N-terminal domain
    3 View Details [177..591] PSI-BLAST 10156.0 Flavocytochrome b2, C-terminal domain; Flavocytochrome b2, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  5.53040931722074 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
    		•  4.99876306143789 bayes_pls_golite062009
  • L-lactate dehydrogenase (cytochrome) activity
    		•  4.62364477397179 bayes_pls_golite062009
  • lactate dehydrogenase activity
    		•  4.48836665081946 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
    		•  4.26416137128289 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.55520438339582 bayes_pls_golite062009
  • 2,4-dienoyl-CoA reductase (NADPH) activity
    		•  2.53740821102118 bayes_pls_golite062009
  • catalytic activity
    		•  1.94749091175302 bayes_pls_golite062009
  • binding
    		•  1.13068993839107 bayes_pls_golite062009
  • (S)-2-hydroxy-acid oxidase activity
    		•  1.08257847863105 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
    		•  0.922853827985629 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  0.449365788564188 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.428925551338656 bayes_pls_golite062009
  • protein binding
    		•  0.174608759343963 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
    		•  0.0276574257865798 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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