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Protein Overview: COX1

General Information:
Name(s) found: COX1 / Q0045 [SGD]
Description(s) found:
Found 24 descriptions.
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  • Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 534 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial respiratory chain complex IV [IPILink to PubMed article]
    Biological Process: mitochondrial electron transport, cytochrome c to oxygen [IDALink to PubMed article]
    aerobic respiration [IMPLink to PubMed article]
    Molecular Function: cytochrome-c oxidase activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG NSQLFNVLVV  60
   61 GHAVLMIFFL VMPALIGGFG NYLLPLMIGA TDTAFPRINN IAFWVLPMGL VCLVTSTLVE 120
  121 SGAGTGWTVY PPLSSIQAHS GPSVDLAIFA LHLTSISSLL GAINFIVTTL NMRTNGMTMH 180
  181 KLPLFVWSIF ITAFLLLLSL PVLSAGITML LLDRNFNTSF FEVSGGGDPI LYEHLFWFFG 240
  241 HPEVYILIIP GFGIISHVVS TYSKKPVFGE ISMVYAMASI GLLGFLVWSH HMYIVGLDAD 300
  301 TRAYFTSATM IIAIPTGIKI FSWLATIHGG SIRLATPMLY AIAFLFLFTM GGLTGVALAN 360
  361 ASLDVAFHDT YYVVGHFHYV LSMGAIFSLF AGYYYWSPQI LGLNYNEKLA QIQFWLIFIG 420
  421 ANVIFFPMHF LGINGMPRRI PDYPDAFAGW NYVASIGSFI ATLSLFLFIY ILYDQLVNGL 480
  481 NNKVNNKSVI YNKAPDFVES NTIFNLNTVK SSSIEFLLTS PPAVHSFNTP AVQS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) COX1 COX12 COX13 COX2 COX3 COX4 COX5A COX6 COX7 COX8 COX9
    View Details Qiu et al. (2008) AAC1 AAC3 ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP19 ATP2 ATP20 ATP4 ATP5 ATP6 ATP7 ATP8 COB COR1 COX1 COX11 COX12 COX13 COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYB2 CYB5 CYC1 CYC7 CYT1 MCR1 MDL2 OLI1 QCR10 QCR2 QCR6 QCR7 QCR8 QCR9 RIP1 SDH1 SDH2 SDH3 SDH4 STF1 STF2 TAZ1 TIM11

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..534] PSI-BLAST 169.0 Mitochondrial cytochrome c oxidase, subunit I

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • heme-copper terminal oxidase activity
    		•  14.1725811596039 bayes_pls_golite062009
  • cytochrome-c oxidase activity
    		•  13.8542976951523 bayes_pls_golite062009
  • oxidoreductase activity, acting on heme group of donors, oxygen as acceptor
    		•  13.8542976951523 bayes_pls_golite062009
  • oxidoreductase activity, acting on heme group of donors
    		•  13.8542976951523 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  7.37127314407573 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  7.21569868255501 bayes_pls_golite062009
  • oxidoreductase activity
    		•  7.16307962729639 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  6.59819712923927 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  6.32599750294462 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  6.1152058837897 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  5.8923420516615 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.6803770025358 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  5.45928453313406 bayes_pls_golite062009
  • catalytic activity
    		•  1.95966890211023 bayes_pls_golite062009
  • oxidoreduction-driven active transmembrane transporter activity
    		•  1.51081278400602 bayes_pls_golite062009
  • electron carrier activity
    		•  1.29518639068237 bayes_pls_golite062009
  • binding
    		•  0.89004160546195 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
    		•  0.531607015518545 bayes_pls_golite062009
  • transporter activity
    		•  0.37947088637216 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.36572623683433 bayes_pls_golite062009
  • protein binding
    		•  0.358081002328109 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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