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Protein Overview: COB

General Information:
Name(s) found: COB / Q0105 [SGD]
Description(s) found:
Found 27 descriptions.
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  • Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 385 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial respiratory chain complex III [IDALink to PubMed articleLink to PubMed article]
    Biological Process: mitochondrial electron transport, ubiquinol to cytochrome c [IMPLink to PubMed article]
    aerobic respiration [IMPLink to PubMed article]
    Molecular Function: ubiquinol-cytochrome-c reductase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFRKSNVYL SLVNSYIIDS PQPSSINYWW NMGSLLGLCL VIQIVTGIFM AMHYSSNIEL  60
   61 AFSSVEHIMR DVHNGYILRY LHANGASFFF MVMFMHMAKG LYYGSYRSPR VTLWNVGVII 120
  121 FILTIATAFL GYCCVYGQMS HWGATVITNL FSAIPFVGND IVSWLWGGFS VSNPTIQRFF 180
  181 ALHYLVPFII AAMVIMHLMA LHIHGSSNPL GITGNLDRIP MHSYFIFKDL VTVFLFMLIL 240
  241 ALFVFYSPNT LGHPDNYIPG NPLVTPASIV PEWYLLPFYA ILRSIPDKLL GVITMFAAIL 300
  301 VLLVLPFTDR SVVRGNTFKV LSKFFFFIFV FNFVLLGQIG ACHVEVPYVL MGQIATFIYF 360
  361 AYFLIIVPVI STIENVLFYI GRVNK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) COB COR1 CYT1 QCR10 QCR2 QCR6 QCR7 QCR8 QCR9 RIP1
    View Details Qiu et al. (2008) AAC1 AAC3 ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP19 ATP2 ATP20 ATP4 ATP5 ATP6 ATP7 ATP8 COB COR1 COX1 COX11 COX12 COX13 COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYB2 CYB5 CYC1 CYC7 CYT1 MCR1 MDL2 OLI1 PET9 QCR10 QCR2 QCR6 QCR7 QCR8 QCR9 RIP1 SDH1 SDH2 SDH3 SDH4 STF1 STF2 TAZ1 TIM11

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..385] PSI-BLAST 148.0 Mitochondrial cytochrome b subunit, C-terminal domain; Mitochondrial cytochrome b subunit, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
    		•  12.6027406026517 bayes_pls_golite062009
  • ubiquinol-cytochrome-c reductase activity
    		•  12.6027406026517 bayes_pls_golite062009
  • electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity
    		•  9.40961255429881 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  9.20388916419937 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  7.91754205622571 bayes_pls_golite062009
  • oxidoreductase activity
    		•  6.47658304679899 bayes_pls_golite062009
  • electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity
    		•  6.28608054530718 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  6.2092870783393 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.7873765619132 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.68072183887254 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  5.3015608578326 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.25342386319285 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  4.56441771839315 bayes_pls_golite062009
  • electron carrier activity
    		•  4.44921672214173 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  3.83149707063563 bayes_pls_golite062009
  • transporter activity
    		•  3.45764306673522 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.38637995472629 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.37175230596465 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  2.22476140193744 bayes_pls_golite062009
  • catalytic activity
    		•  1.19342057724506 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  1.03512868485178 bayes_pls_golite062009
  • binding
    		•  0.774901332897627 bayes_pls_golite062009
  • protein binding
    		•  0.404482007264961 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.158842209858127 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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