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Protein Overview: ATP1

General Information:
Name(s) found: ATP1 / YBL099W [SGD]
Description(s) found:
Found 18 descriptions.
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  • Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 545 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article][IPILink to PubMed article]
    mitochondrial proton-transporting ATP synthase, catalytic core [IMPLink to PubMed article][ISSLink to PubMed article]
    mitochondrial nucleoid [IDALink to PubMed article]
    Biological Process: ATP synthesis coupled proton transport [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: hydrogen ion transporting ATP synthase activity, rotational mechanism [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLARTAAIRS LSRTLINSTK AARPAAAALA STRRLASTKA QPTEVSSILE ERIKGVSDEA  60
   61 NLNETGRVLA VGDGIARVFG LNNIQAEELV EFSSGVKGMA LNLEPGQVGI VLFGSDRLVK 120
  121 EGELVKRTGN IVDVPVGPGL LGRVVDALGN PIDGKGPIDA AGRSRAQVKA PGILPRRSVH 180
  181 EPVQTGLKAV DALVPIGRGQ RELIIGDRQT GKTAVALDTI LNQKRWNNGS DESKKLYCVY 240
  241 VAVGQKRSTV AQLVQTLEQH DAMKYSIIVA ATASEAAPLQ YLAPFTAASI GEWFRDNGKH 300
  301 ALIVYDDLSK QAVAYRQLSL LLRRPPGREA YPGDVFYLHP RLLERAAKLS EKEGSGSLTA 360
  361 LPVIETQGGD VSAYIPTNVI SITDGQIFLE AELFYKGIRP AINVGLSVSR VGSAAQVKAL 420
  421 KQVAGSLKLF LAQYREVAAF AQFGSDLDAS TKQTLVRGER LTQLLKQNQY SPLATEEQVP 480
  481 LIYAGVNGHL DGIELSRIGE FESSFLSYLK SNHNELLTEI REKGELSKEL LASLKSATES 540
  541 FVATF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATP1 ATP2
    View Details (MIPS) Mewes HW, et al. (2004) ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP19 ATP2 ATP20 ATP3 ATP4 ATP5 ATP6 ATP7 ATP8 INH1 OLI1 TIM11
    View Details Krogan NJ, et al. (2006) ATP1 ATP2
    View Details Gavin AC, et al. (2006) ATP1 ATP3
    View Details Qiu et al. (2008) ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP19 ATP2 ATP20 ATP3 ATP4 ATP5 ATP6 ATP7 ATP8 COB COX1 COX2 COX3 COX4 COX5A COX6 COX7 COX8 COX9 CYT1 INH1 LPD1 MIR1 NDI1 OLI1 QCR10 QCR2 QCR7 QCR8 QCR9 RIP1 STF1 TIM11 YJR079W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ATP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] PSI-BLAST 11000.0 F1 ATP synthase alpha subunit, domain 3; F1 ATP synthase alpha subunit, domain 1; Central domain of alpha subunit of F1 ATP synthase
    2 View Details [132..416] PSI-BLAST 11000.0 F1 ATP synthase alpha subunit, domain 3; F1 ATP synthase alpha subunit, domain 1; Central domain of alpha subunit of F1 ATP synthase
    3 View Details [417..545] PSI-BLAST 11000.0 F1 ATP synthase alpha subunit, domain 3; F1 ATP synthase alpha subunit, domain 1; Central domain of alpha subunit of F1 ATP synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  10.4627263027269 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  9.07129841752891 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  7.35625288284796 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  6.62734320850541 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  4.03326929098701 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.4837867129694 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  3.28373827150339 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  2.31476707827367 bayes_pls_golite062009
  • binding
    		•  2.21604035604783 bayes_pls_golite062009
  • cell surface binding
    		•  2.12695960098007 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • hydrolase activity
    		•  1.65763522573119 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.56007674693172 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.53142082854758 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.52938239070386 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.52887308780164 bayes_pls_golite062009
  • nucleotide binding
    		•  1.52746968836881 bayes_pls_golite062009
  • ATP binding
    		•  1.23942044024113 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.21044170258803 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.19481945569892 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.03415266410463 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.908137002406423 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.905276329867465 bayes_pls_golite062009
  • motor activity
    		•  0.87979065815418 bayes_pls_golite062009
  • potassium channel activity
    		•  0.843657228494419 bayes_pls_golite062009
  • GTPase activity
    		•  0.83849854735032 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  0.69784475011795 bayes_pls_golite062009
  • kinase activity
    		•  0.641541011250583 bayes_pls_golite062009
  • cation channel activity
    		•  0.601686039699302 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  0.563503770238611 bayes_pls_golite062009
  • protein kinase activity
    		•  0.529485140575818 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.503971340374059 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  0.46842047319323 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  0.43332053110728 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.40876498215632 bayes_pls_golite062009
    		• 0.3586311431823 bayes_pls_golite062009
  • helicase activity
    		•  0.32448546535964 bayes_pls_golite062009
  • gated channel activity
    		•  0.299411774392227 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.226231702119567 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  0.175442402308287 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • ion channel activity
    		•  0.154779598791225 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.134817721656507 bayes_pls_golite062009
  • channel activity
    		•  0.134817721656507 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.126911677161968 bayes_pls_golite062009
  • DNA binding
    		•  0.111331583742205 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle