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Protein Overview: ZDS1

General Information:
Name(s) found: ZDS1 / YMR273C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of PKA subunit Bcy1p; implicated in mRNA nuclear export; involved in mitotic exit through regulation of Cdc14p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 915 amino acids

    Gene Ontology:
    Cellular Component: cellular bud tip [IDALink to PubMed article]
    cytoplasm [IPILink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    nuclear pore [IPILink to PubMed article]
    Biological Process: mRNA export from nucleus [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    chromatin silencing [IMPLink to PubMed article]
    cell aging [IMPLink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNRDNESML RTTSSDKAIA SQRDKRKSEV LIAAQSLDNE IRSVKNLKRL SIGSMDLLID  60
   61 PELDIKFGGE SSGRRSWSGT TSSSASMPSD TTTVNNTRYS DPTPLENLHG RGNSGIESSN 120
  121 KTKQGNYLGI KKGVHSPSRK LNANVLKKNL LWVPANQHPN VKPDNFLELV QDTLQNIQLS 180
  181 DNGEDNDGNS NENNDIEDNG EDKESQSYEN KENNTINLNR GLSRHGNASL IRRPSTLRRS 240
  241 YTEFDDNEDD DNKGDSASET VNKVEERISK IKERPVSLRD ITEELTKISN SAGLTDNDAI 300
  301 TLARTLSMAG SYSDKKDQPQ PEGHYDEGDI GFSTSQANTL DDGEFASNMP INNTMTWPER 360
  361 SSLRRSRFNT YRIRSQEQEK EVEQSVDEMK NDDEERLKLT KNTIKVEIDP HKSPFRQQDE 420
  421 DSENMSSPGS IGDFQDIYNH YRQSSGEWEQ EMGIEKEAEE VPVKVRNDTV EQDLELREGT 480
  481 TDMVKPSATD DNKETKRHRR RNGWTWLNNK MSREDDNEEN QGDDENEENV DSQRMELDNS 540
  541 KKHYISLFNG GEKTEVSNKE EMNNSSTSTA TSQTRQKIEK TFANLFRRKP HHKHDASSSP 600
  601 SSSPSSSPSI PNNDAVHVRV RKSKKLGNKS GREPVEPIVL RNRPRPHRHH HSRHGSQKIS 660
  661 VKTLKDSQPQ QQIPLQPQLE GAIEIEKKEE SDSESLPQLQ PAVSVSSTKS NSRDREEEEA 720
  721 KKKNKKRSNT TEISNQQHSK HVQKENTDEQ KAQLQAPAQE QVQTSVPVQA SAPVQNSAPV 780
  781 QTSAPVEASA QTQAPAAPPL KHTSILPPRK LTFADVKKPD KPNSPVQFTD SAFGFPLPLL 840
  841 TVSTVIMFDH RLPINVERAI YRLSHLKLSN SKRGLREQVL LSNFMYAYLN LVNHTLYMEQ 900
  901 VAHDKEQQQQ QQQQP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC55 PPH21 PPH22 RRD2 RTS1 TPD3 ZDS1 ZDS2
    View Details Krogan NJ, et al. (2006) CDC55 FIR1 PHR1 PPH21 PPH22 RRD2 TPD3 YRR1 ZDS1 ZDS2
    View Details Gavin AC, et al. (2006) CDC55 RTS3 TPD3 ZDS1 ZDS2
    View Details Gavin AC, et al. (2002) BLM10 CDC55 CIN1 ERG13 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 KAP95 KEL1 LTE1 MYO5 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RRD2 RTS1 RTS3 SCL1 SET3 SIF2 SNT1 SRP1 TDH2 TDH3 TEF4 TPD3 YBL104C YOR1 YRA1 ZDS1 ZDS2
    View Details Qiu et al. (2008) BEM1 BOI1 BOI2 SUS1 ZDS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample zds1 from august 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample zds1 gel band from august 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ZDS1 ZDS2 2 Drees BL, et al. (2001)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ZDS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..247] deduced N/A No confident structure predictions are available.
    2 View Details [248..851] MSA 30.269998 View MSA. No confident structure predictions are available.
    3 View Details [852..915] deduced N/A No confident structure predictions are available.
    4 View Details [460..605] PSI-BLAST 8.0 Solution Structure of Choline Binding Protein A, Domain R2, the Major Adhesin of Streptococcus pneumoniae
    5 View Details [606..774] MSA 3.329996 View MSA. No confident structure predictions are available.
    6 View Details [775..837] deduced N/A No confident structure predictions are available.
    7 View Details [838..915] MSA 1.057994 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle