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Protein Overview: PHR1

General Information:
Name(s) found: PHR1 / YOR386W [SGD]
Description(s) found:
Found 26 descriptions.
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  • DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 565 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: photoreactive repair [TASLink to PubMed article]
    Molecular Function: deoxyribodipyrimidine photo-lyase activity [IDALink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRTVISSSN AYASKRSRLD IEHDFEQYHS LNKKYYPRPI TRTGANQFNN KSRAKPMEIV  60
   61 EKLQKKQKTS FENVSTVMHW FRNDLRLYDN VGLYKSVALF QQLRQKNAKA KLYAVYVINE 120
  121 DDWRAHMDSG WKLMFIMGAL KNLQQSLAEL HIPLLLWEFH TPKSTLSNSK EFVEFFKEKC 180
  181 MNVSSGTGTI ITANIEYQTD ELYRDIRLLE NEDHRLQLKY YHDSCIVAPG LITTDRGTNY 240
  241 SVFTPWYKKW VLYVNNYKKS TSEICHLHII EPLKYNETFE LKPFQYSLPD EFLQYIPKSK 300
  301 WCLPDVSEEA ALSRLKDFLG TKSSKYNNEK DMLYLGGTSG LSVYITTGRI STRLIVNQAF 360
  361 QSCNGQIMSK ALKDNSSTQN FIKEVAWRDF YRHCMCNWPY TSMGMPYRLD TLDIKWENNP 420
  421 VAFEKWCTGN TGIPIVDAIM RKLLYTGYIN NRSRMITASF LSKNLLIDWR WGERWFMKHL 480
  481 IDGDSSSNVG GWGFCSSTGI DAQPYFRVFN MDIQAKKYDP QMIFVKQWVP ELISSENKRP 540
  541 ENYPKPLVDL KHSRERALKV YKDAM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CDC55 FIR1 PHR1 PPH21 PPH22 RRD2 TPD3 YRR1 ZDS1 ZDS2
    View Details Ho Y, et al. (2002) MSD1 PHR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PHR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..71] deduced N/A No confident structure predictions are available.
    2 View Details [72..224]
    [260..284]    		 PSI-BLAST 809.0103 C-terminal domain of DNA photolyase; DNA photolyase
    3 View Details [225..259]
    [285..400]    		 PSI-BLAST 809.0103 C-terminal domain of DNA photolyase; DNA photolyase
    4 View Details [401..565] PSI-BLAST 809.0103 C-terminal domain of DNA photolyase; DNA photolyase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • blue light photoreceptor activity
    		•  9.1431674572348 bayes_pls_golite062009
  • photoreceptor activity
    		•  6.86138041842095 bayes_pls_golite062009
  • DNA photolyase activity
    		•  5.59238172310626 bayes_pls_golite062009
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.49617875539388 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • binding
    		•  2.13238451443633 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • deoxyribodipyrimidine photo-lyase activity
    		•  2.01343813518186 bayes_pls_golite062009
  • FAD binding
    		•  1.81559602758107 bayes_pls_golite062009
  • G-protein coupled photoreceptor activity
    		•  0.698591133261382 bayes_pls_golite062009
  • catalytic activity
    		•  0.609980967042895 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.5555984473366 bayes_pls_golite062009
  • protein binding
    		•  0.452275661161724 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle