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View Structure Prediction Details

Protein: PHR1
Organism: Saccharomyces cerevisiae
Length: 565 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHR1.

Description E-value Query
Range
Subject
Range
PHR1 - DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible l...
gi|207340799 - gi|207340799|gb|EDZ69038.1| YOR386Wp-like protein [Saccharomyces cerevisiae AWRI1631]
PHR_YEAST - Deoxyribodipyrimidine photo-lyase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...
gi|151945461 - gi|151945461|gb|EDN63704.1| photolyase [Saccharomyces cerevisiae YJM789]
0.0 [1..565] [1..565]
gi|30315019 - gi|30315019|gb|AAP30741.1|AF500083_1 photolyase [Fusarium oxysporum]
0.0 [2..565] [57..626]
gi|3947746 - gi|3947746|emb|CAA08916.1| DNA photolyase [Hypocrea lixii]
0.0 [13..565] [67..625]
PHR_NEUCR - Deoxyribodipyrimidine photo-lyase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 ...
PHR_NEUCR - Deoxyribodipyrimidine photo-lyase OS=Neurospora crassa GN=phr-1 PE=3 SV=1
0.0 [2..565] [52..638]
gi|29467479 - gi|29467479|dbj|BAC67178.1| cryptochrome 2 [Armoracia rusticana]
0.0 [71..563] [1..487]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [69..563] [1..487]
CRY2_ARATH - Cryptochrome-2 OS=Arabidopsis thaliana GN=CRY2 PE=1 SV=2
0.0 [69..563] [1..487]

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Predicted Domain #1
Region A:
Residues: [1-71]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRTVISSSN AYASKRSRLD IEHDFEQYHS LNKKYYPRPI TRTGANQFNN KSRAKPMEIV  60
   61 EKLQKKQKTS F

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
blue light photoreceptor activity 9.1431674572348 bayes_pls_golite062009
photoreceptor activity 6.86138041842095 bayes_pls_golite062009
DNA photolyase activity 5.59238172310626 bayes_pls_golite062009
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
transcription regulator activity 3.49617875539388 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
binding 2.13238451443633 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
deoxyribodipyrimidine photo-lyase activity 2.01343813518186 bayes_pls_golite062009
FAD binding 1.81559602758107 bayes_pls_golite062009
G-protein coupled photoreceptor activity 0.698591133261382 bayes_pls_golite062009
catalytic activity 0.609980967042895 bayes_pls_golite062009
damaged DNA binding 0.5555984473366 bayes_pls_golite062009
protein binding 0.452275661161724 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [72-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENVSTVMHWF RNDLRLYDNV GLYKSVALFQ QLRQKNAKAK LYAVYVINED DWRAHMDSGW  60
   61 KLMFIMGALK NLQQSLAELH IPLLLWEFHT PKSTLSNSKE FVEFFKEKCM NVSSGTGTII 120
  121 TANIEYQTDE LYRDIRLLEN EDHRLQLKYY HDS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [260-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STSEICHLHI IEPLKYNETF ELKPF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 809.0103
Match: 1dnpA_
Description: C-terminal domain of DNA photolyase; DNA photolyase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [225-259]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CIVAPGLITT DRGTNYSVFT PWYKKWVLYV NNYKK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [285-400]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYSLPDEFLQ YIPKSKWCLP DVSEEAALSR LKDFLGTKSS KYNNEKDMLY LGGTSGLSVY  60
   61 ITTGRISTRL IVNQAFQSCN GQIMSKALKD NSSTQNFIKE VAWRDFYRHC MCNWPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 809.0103
Match: 1dnpA_
Description: C-terminal domain of DNA photolyase; DNA photolyase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [401-565]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSMGMPYRLD TLDIKWENNP VAFEKWCTGN TGIPIVDAIM RKLLYTGYIN NRSRMITASF  60
   61 LSKNLLIDWR WGERWFMKHL IDGDSSSNVG GWGFCSSTGI DAQPYFRVFN MDIQAKKYDP 120
  121 QMIFVKQWVP ELISSENKRP ENYPKPLVDL KHSRERALKV YKDAM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 809.0103
Match: 1dnpA_
Description: C-terminal domain of DNA photolyase; DNA photolyase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle