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Protein Overview: PPH22

General Information:
Name(s) found: PPH22 / YDL188C [SGD]
Description(s) found:
Found 38 descriptions.
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  • Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 377 amino acids

    Gene Ontology:
    Cellular Component: condensed nuclear chromosome, centromeric region [IDALink to PubMed article]
    protein phosphatase type 2A complex [TASLink to PubMed article]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [IPILink to PubMed article]
    G1/S transition of mitotic cell cycle [IGILink to PubMed article]
    protein amino acid dephosphorylation [IDALink to PubMed article]
    actin filament organization [TASLink to PubMed article]
    budding cell bud growth [TASLink to PubMed article]
    translation [IPILink to PubMed article]
    Molecular Function: protein serine/threonine phosphatase activity [IDA]
    phosphoprotein phosphatase activity [IEA]
    metal ion binding [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMEIDDPMH GSDEDQLSPT LDEDMNSDDG KNNTKARSND EDTDEELEDF NFKPGSSGIA  60
   61 DHKSSKPLKL TNTNINQLDQ WIEHLSKCEP LSEDDVARLC KMAVDVLQFE ENVKPINVPV 120
  121 TICGDVHGQF HDLLELFKIG GPCPDTNYLF MGDYVDRGYY SVETVSYLVA MKVRYPHRIT 180
  181 ILRGNHESRQ ITQVYGFYDE CLRKYGSANV WKMFTDLFDY FPVTALVDNK IFCLHGGLSP 240
  241 MIETIDQVRD LNRIQEVPHE GPMCDLLWSD PDDRGGWGIS PRGAGFTFGQ DISEQFNHTN 300
  301 DLSLIARAHQ LVMEGYSWSH QQNVVTIFSA PNYCYRCGNQ AAIMEVDENH NRQFLQYDPS 360
  361 VRPGEPTVTR KTPDYFL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC55 PPH21 PPH22 RRD2 RTS1 TPD3 ZDS1 ZDS2
    View Details Krogan NJ, et al. (2006) CDC55 FIR1 PHR1 PPH21 PPH22 RRD2 TPD3 YRR1 ZDS1 ZDS2
    View Details Gavin AC, et al. (2002) BLM10 CDC55 CIN1 ERG13 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 KAP95 KEL1 LTE1 MYO5 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RRD2 RTS1 RTS3 SCL1 SET3 SIF2 SNT1 SRP1 TDH2 TDH3 TEF4 TPD3 YBL104C YOR1 YRA1 ZDS1 ZDS2
    View Details Ho Y, et al. (2002) AHA1 ARP2 ATP3 CCT2 CCT3 CCT5 CCT6 CDC55 CPR6 GPG1 HEM15 HTA2 IDH1 MKT1 NMD5 PDC5 PET10 PHO84 PPE1 PPH21 PPH22 PRB1 REP1 RPA135 RPB11 RPC40 RPN8 RTS1 RTS3 RVB1 SDH2 SPS1 TAP42 TCP1 THI21 TPD3 ULA1 VMA8 VPS74 YCK1 YCK2 YHR033W
    View Details Qiu et al. (2008) CDC55 CMP2 GIP2 GLC7 HSK3 PPH21 PPH22 RTS1 RTS3 TPD3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PPH22 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..377] PSI-BLAST 912.0 Protein phosphatase-1 (PP-1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  6.04386346716682 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.126411744957937 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle