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Protein Overview: SDH2

General Information:
Name(s) found: SDH2 / YLL041C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 266 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial respiratory chain complex II [TASLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: tricarboxylic acid cycle [TASLink to PubMed article]
    mitochondrial electron transport, succinate to ubiquinone [TASLink to PubMed article]
    Molecular Function: succinate dehydrogenase (ubiquinone) activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNVLLRRKA FCLVTKKGMA TATTAAATHT PRLKTFKVYR WNPDEPSAKP HLQSYQVDLN  60
   61 DCGPMVLDAL LKIKDEQDST LTFRRSCREG ICGSCAMNIG GRNTLACICK IDQNESKQLK 120
  121 IYPLPHMFIV KDLVPDLTNF YQQYKSIQPY LQRSSFPKDG TEVLQSIEDR KKLDGLYECI 180
  181 LCACCSTSCP SYWWNQEQYL GPAVLMQAYR WLIDSRDQAT KTRKAMLNNS MSLYRCHTIM 240
  241 NCTRTCPKGL NPGLAIAEIK KSLAFA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) SDH1 SDH2 SDH3 SDH4
    View Details Ho Y, et al. (2002) AHA1 ARP2 ATP3 CPR6 IDH1 NMD5 PET10 PHO84 PPH21 PPH22 PRB1 REP1 RPN8 SDH2 SPS1 VMA8 VPS74 YHR033W
    View Details Qiu et al. (2008) ATP15 COB COR1 COX1 COX13 COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYT1 MCR1 QCR10 QCR2 QCR6 QCR7 QCR8 QCR9 RIP1 SDH1 SDH2 SDH3 SDH4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SDH2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..136] PSI-BLAST 341.502279 Fumarate reductase; Fumarate reductase iron-sulfur protein, N-terminal domain
    2 View Details [137..266] PSI-BLAST 341.502279 Fumarate reductase; Fumarate reductase iron-sulfur protein, N-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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