Protein Overview: COX4

General Information:
Name(s) found:	COX4 / YGL187C [SGD]
Description(s) found: Found 40 descriptions. SHOW ALL	Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation [SGD]
Organism:	Saccharomyces cerevisiae
Length:	155 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial respiratory chain complex IV [IPI]
Biological Process:	mitochondrial electron transport, cytochrome c to oxygen [IDA] aerobic respiration [IPI]
Molecular Function:	zinc ion binding [IDA] cytochrome-c oxidase activity [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSLRQSIRF FKPATRTLCS SRYLLQQKPV VKTAQNLAEV NGPETLIGPG AKEGTVPTDL  60
   61 DQETGLARLE LLGKLEGIDV FDTKPLDSSR KGTMKDPIII ESYDDYRYVG CTGSPAGSHT 120
  121 IMWLKPTVNE VARCWECGSV YKLNPVGVPN DDHHH

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		COX1 COX12 COX13 COX2 COX3 COX4 COX5A COX6 COX7 COX8 COX9
View Details	Krogan NJ, et al. (2006)		COX4 COX5A
View Details	Gavin AC, et al. (2002)		COX4 COX5A COX6
View Details	Qiu et al. (2008)		AAC1 ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP2 ATP20 ATP4 ATP5 ATP6 ATP7 ATP8 COB COR1 COX1 COX12 COX13 COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYC1 CYT1 INH1 MCR1 OLI1 QCR2 QCR6 QCR7 QCR8 RIP1 SDH1 SDH2 SDH3 SDH4

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	NPA3	COX4	2	Unpublished Fields Lab Data
View Screen	HSL7	COX4	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	COX4	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..155]	PSI-BLAST	120.156545	Cytochrome c oxidase Subunit F
2	View Details	[77..155]	PSI-BLAST	30.69897	No description for 2odxA was found.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2